Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01335:Tatdn2'

74599

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tatdn2

Ensembl Gene

ENSMUSG00000056952

Gene Name

TatD DNase domain containing 2

Synonyms

mKIAA0218

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01335

Quality Score

Status

Chromosome

Chromosomal Location

113674090-113688030 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 113681017 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 289 (M289K)

Ref Sequence

ENSEMBL: ENSMUSP00000086412 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089018] [ENSMUST00000113022] [ENSMUST00000153661] [ENSMUST00000204753]

AlphaFold

B7ZNL9

Predicted Effect

probably benign
Transcript: ENSMUST00000089018
AA Change: M289K

PolyPhen 2 Score 0.294 (Sensitivity: 0.91; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000086412
Gene: ENSMUSG00000056952
AA Change: M289K

Domain	Start	End	E-Value	Type
low complexity region	63	95	N/A	INTRINSIC
low complexity region	237	255	N/A	INTRINSIC
low complexity region	382	392	N/A	INTRINSIC
Pfam:TatD_DNase	457	721	3.3e-59	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000113022
AA Change: M350K

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000108645
Gene: ENSMUSG00000056952
AA Change: M350K

Domain	Start	End	E-Value	Type
low complexity region	63	95	N/A	INTRINSIC
low complexity region	237	255	N/A	INTRINSIC
low complexity region	443	453	N/A	INTRINSIC
Pfam:TatD_DNase	518	782	3.7e-61	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138420

SMART Domains

Protein: ENSMUSP00000116559
Gene: ENSMUSG00000056952

Domain	Start	End	E-Value	Type
Pfam:TatD_DNase	1	146	2.9e-38	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000153661

SMART Domains

Protein: ENSMUSP00000123557
Gene: ENSMUSG00000056952

Domain	Start	End	E-Value	Type
Pfam:TatD_DNase	1	122	1.3e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200187

Predicted Effect

probably benign
Transcript: ENSMUST00000204753
AA Change: M350K

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000145308
Gene: ENSMUSG00000056952
AA Change: M350K

Domain	Start	End	E-Value	Type
low complexity region	63	95	N/A	INTRINSIC
low complexity region	237	255	N/A	INTRINSIC
low complexity region	443	453	N/A	INTRINSIC
Pfam:TatD_DNase	518	782	3.7e-61	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6820408C15Rik	T	A	2: 152,284,307 (GRCm39)	M300K	possibly damaging	Het
Adamts14	T	A	10: 61,034,460 (GRCm39)	R1143W	possibly damaging	Het
Ankrd28	T	C	14: 31,423,981 (GRCm39)	Y1083C	probably damaging	Het
Anxa8	T	C	14: 33,811,547 (GRCm39)	M34T	probably damaging	Het
Aox1	G	T	1: 58,121,312 (GRCm39)	E928*	probably null	Het
Atp8b5	T	A	4: 43,302,628 (GRCm39)	F50L	possibly damaging	Het
Brpf1	A	G	6: 113,296,298 (GRCm39)	S863G	probably damaging	Het
Cdc42bpb	A	G	12: 111,260,530 (GRCm39)		probably benign	Het
Cdh6	C	T	15: 13,051,395 (GRCm39)	A413T	probably benign	Het
Cfap96	A	T	8: 46,426,642 (GRCm39)		probably benign	Het
Cfap97	A	G	8: 46,623,492 (GRCm39)	Q294R	probably damaging	Het
Cit	C	T	5: 116,046,889 (GRCm39)		probably benign	Het
Dmbt1	A	G	7: 130,690,497 (GRCm39)	Y736C	possibly damaging	Het
Eno2	C	T	6: 124,743,618 (GRCm39)	G107E	probably damaging	Het
Gja8	T	C	3: 96,826,558 (GRCm39)	Q368R	probably benign	Het
Gm3633	T	A	14: 42,462,595 (GRCm39)		probably benign	Het
Gm4987	A	T	X: 45,544,755 (GRCm39)		noncoding transcript	Het
Gna13	G	A	11: 109,256,569 (GRCm39)	R164Q	probably damaging	Het
Grhl1	A	T	12: 24,658,057 (GRCm39)	E351D	probably damaging	Het
Idua	A	G	5: 108,828,737 (GRCm39)	Q280R	probably benign	Het
Igsf5	T	A	16: 96,174,353 (GRCm39)		probably benign	Het
Mrpl52	T	C	14: 54,664,656 (GRCm39)	Y39H	probably damaging	Het
Naa16	A	T	14: 79,582,556 (GRCm39)		probably benign	Het
Naa35	T	A	13: 59,764,610 (GRCm39)	L338Q	probably damaging	Het
Nat8l	A	T	5: 34,155,791 (GRCm39)	Y149F	probably benign	Het
Nck1	A	T	9: 100,379,790 (GRCm39)	W154R	probably damaging	Het
Ncoa1	A	T	12: 4,347,520 (GRCm39)	S351R	probably benign	Het
Or10w1	A	T	19: 13,632,540 (GRCm39)	H249L	probably damaging	Het
Or12e10	A	T	2: 87,640,790 (GRCm39)	T209S	probably damaging	Het
Or6c8b	T	C	10: 128,882,380 (GRCm39)	K184R	probably benign	Het
Or8k1	A	T	2: 86,047,916 (GRCm39)	L46Q	probably damaging	Het
Pacs1	A	T	19: 5,192,660 (GRCm39)	V624E	probably damaging	Het
Pde6b	G	A	5: 108,571,379 (GRCm39)	R444H	probably benign	Het
Pigk	A	T	3: 152,448,173 (GRCm39)	T226S	probably benign	Het
Prkdc	T	C	16: 15,634,760 (GRCm39)		probably null	Het
Ptbp1	G	A	10: 79,698,708 (GRCm39)		probably null	Het
Pyroxd1	T	C	6: 142,307,484 (GRCm39)	V418A	probably damaging	Het
Rhot1	A	T	11: 80,141,055 (GRCm39)	D421V	probably damaging	Het
Rimkla	T	C	4: 119,335,156 (GRCm39)	T76A	possibly damaging	Het
Rtn1	A	G	12: 72,355,124 (GRCm39)	V274A	probably benign	Het
Trak1	A	G	9: 121,283,382 (GRCm39)	T476A	possibly damaging	Het
Ube2i	C	A	17: 25,488,410 (GRCm39)	Q11H	probably damaging	Het
Ugt2a3	A	T	5: 87,484,644 (GRCm39)	C127S	probably damaging	Het
Uimc1	T	A	13: 55,182,724 (GRCm39)	Q619L	probably benign	Het
Upk3a	T	A	15: 84,903,786 (GRCm39)	Y162N	probably damaging	Het
Usp33	T	C	3: 152,097,854 (GRCm39)	S849P	probably damaging	Het
Vmn2r120	G	A	17: 57,832,732 (GRCm39)	T149I	possibly damaging	Het
Vmn2r15	G	A	5: 109,434,602 (GRCm39)	P701S	possibly damaging	Het
Vmn2r28	T	C	7: 5,484,087 (GRCm39)	I704M	possibly damaging	Het
Wdhd1	T	C	14: 47,488,239 (GRCm39)	E756G	possibly damaging	Het
Xlr3c	C	A	X: 72,303,639 (GRCm39)	V102F	probably benign	Het
Zfp384	T	G	6: 125,002,016 (GRCm39)	D220E	probably benign	Het
Zfp521	A	T	18: 13,977,776 (GRCm39)	V879E	probably benign	Het

Other mutations in Tatdn2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01302:Tatdn2	APN	6	113,680,985 (GRCm39)	splice site	probably benign
IGL01459:Tatdn2	APN	6	113,686,992 (GRCm39)	splice site	probably null
IGL02406:Tatdn2	APN	6	113,681,174 (GRCm39)	missense	probably benign	0.41
IGL02728:Tatdn2	APN	6	113,681,676 (GRCm39)	missense	probably damaging	1.00
R0321:Tatdn2	UTSW	6	113,686,462 (GRCm39)	missense	probably damaging	1.00
R0506:Tatdn2	UTSW	6	113,679,550 (GRCm39)	missense	probably benign	0.13
R0583:Tatdn2	UTSW	6	113,679,486 (GRCm39)	missense	possibly damaging	0.80
R1022:Tatdn2	UTSW	6	113,686,506 (GRCm39)	missense	probably damaging	1.00
R1024:Tatdn2	UTSW	6	113,686,506 (GRCm39)	missense	probably damaging	1.00
R1301:Tatdn2	UTSW	6	113,681,076 (GRCm39)	missense	probably damaging	1.00
R1454:Tatdn2	UTSW	6	113,681,288 (GRCm39)	missense	probably benign	0.26
R1459:Tatdn2	UTSW	6	113,687,031 (GRCm39)	missense	probably damaging	1.00
R1710:Tatdn2	UTSW	6	113,674,888 (GRCm39)	missense	possibly damaging	0.90
R1771:Tatdn2	UTSW	6	113,679,060 (GRCm39)	critical splice acceptor site	probably null
R2064:Tatdn2	UTSW	6	113,681,103 (GRCm39)	missense	probably benign	0.41
R2065:Tatdn2	UTSW	6	113,681,103 (GRCm39)	missense	probably benign	0.41
R2067:Tatdn2	UTSW	6	113,681,103 (GRCm39)	missense	probably benign	0.41
R4446:Tatdn2	UTSW	6	113,679,501 (GRCm39)	critical splice donor site	probably null
R4654:Tatdn2	UTSW	6	113,684,326 (GRCm39)	missense	probably benign	0.09
R4888:Tatdn2	UTSW	6	113,681,566 (GRCm39)	missense	possibly damaging	0.66
R7378:Tatdn2	UTSW	6	113,681,662 (GRCm39)	missense	probably damaging	1.00
R7971:Tatdn2	UTSW	6	113,687,235 (GRCm39)	splice site	probably null
R8086:Tatdn2	UTSW	6	113,686,482 (GRCm39)	missense	probably damaging	1.00
R8833:Tatdn2	UTSW	6	113,684,348 (GRCm39)	missense	probably damaging	1.00
R8872:Tatdn2	UTSW	6	113,681,170 (GRCm39)	missense	probably damaging	1.00
R9186:Tatdn2	UTSW	6	113,687,125 (GRCm39)	missense	probably benign	0.13
R9234:Tatdn2	UTSW	6	113,679,683 (GRCm39)	critical splice donor site	probably null

Posted On

2013-10-07