Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01337:Vmn1r62'

74651

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r62

Ensembl Gene

ENSMUSG00000092579

Gene Name

vomeronasal 1 receptor 62

Synonyms

V3R2, V1rd8, V1rd2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.043) question?

Stock #

IGL01337

Quality Score

Status

Chromosome

Chromosomal Location

5677603-5679598 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 5679144 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 275 (I275N)

Ref Sequence

ENSEMBL: ENSMUSP00000134168 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000173956]

AlphaFold

Q8R2C0

Predicted Effect

probably damaging
Transcript: ENSMUST00000173956
AA Change: I275N

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000134168
Gene: ENSMUSG00000092579
AA Change: I275N

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	296	2.8e-11	PFAM
Pfam:7tm_1	20	279	3.1e-6	PFAM
Pfam:V1R	31	299	4.2e-18	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	C	6: 121,645,529 (GRCm39)	Y1025H	probably damaging	Het
Adarb2	T	C	13: 8,620,282 (GRCm39)	L256P	probably benign	Het
Arsj	A	G	3: 126,158,763 (GRCm39)	Y114C	probably damaging	Het
Bdp1	G	A	13: 100,192,700 (GRCm39)	P1378L	probably benign	Het
Clca3a2	T	C	3: 144,800,939 (GRCm39)	Y138C	probably damaging	Het
Dsp	G	A	13: 38,376,663 (GRCm39)	D1483N	probably benign	Het
Etl4	T	C	2: 20,790,198 (GRCm39)	S617P	probably benign	Het
Fbxo34	T	C	14: 47,767,674 (GRCm39)	S345P	probably benign	Het
Gm5420	A	G	10: 21,567,514 (GRCm39)		noncoding transcript	Het
Gpr182	T	A	10: 127,586,655 (GRCm39)	I99F	possibly damaging	Het
Hectd1	A	G	12: 51,849,057 (GRCm39)	I349T	possibly damaging	Het
Kifc5b	A	G	17: 27,143,718 (GRCm39)	T497A	possibly damaging	Het
Mllt3	A	C	4: 87,759,057 (GRCm39)	D330E	probably damaging	Het
Mpp3	T	C	11: 101,891,411 (GRCm39)	T576A	probably benign	Het
Mroh2b	A	G	15: 4,934,506 (GRCm39)	M126V	probably benign	Het
Naalad2	T	G	9: 18,238,669 (GRCm39)	D644A	probably damaging	Het
Or4a74	A	G	2: 89,439,720 (GRCm39)	I242T	probably damaging	Het
Otof	C	A	5: 30,563,121 (GRCm39)	A242S	possibly damaging	Het
Otof	T	C	5: 30,576,856 (GRCm39)	D132G	probably benign	Het
Pdk4	T	A	6: 5,491,869 (GRCm39)	M68L	probably benign	Het
Ptprf	A	G	4: 118,093,488 (GRCm39)	Y385H	probably damaging	Het
Rxrb	A	G	17: 34,255,605 (GRCm39)	N254S	probably damaging	Het
Samd5	T	A	10: 9,504,768 (GRCm39)	Y162F	probably benign	Het
Sapcd2	A	G	2: 25,266,491 (GRCm39)	*392W	probably null	Het
Senp6	T	C	9: 80,043,792 (GRCm39)	Y635H	probably damaging	Het
Serpine1	C	A	5: 137,098,185 (GRCm39)	V163L	probably damaging	Het
Slc15a1	T	C	14: 121,698,091 (GRCm39)	E678G	possibly damaging	Het
Slc22a16	T	C	10: 40,471,310 (GRCm39)	F494L	possibly damaging	Het
Slc5a12	T	A	2: 110,450,718 (GRCm39)	C304*	probably null	Het
Spink1	G	A	18: 43,870,216 (GRCm39)		probably benign	Het
Star	G	A	8: 26,299,892 (GRCm39)	G78E	probably damaging	Het
Stx1a	T	C	5: 135,074,518 (GRCm39)	I203T	probably damaging	Het
Tap2	A	G	17: 34,424,386 (GRCm39)		probably benign	Het
Trim75	T	C	8: 65,436,387 (GRCm39)	D21G	possibly damaging	Het

Other mutations in Vmn1r62

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01650:Vmn1r62	APN	7	5,679,024 (GRCm39)	missense	probably damaging	1.00
IGL02892:Vmn1r62	APN	7	5,679,202 (GRCm39)	missense	probably benign
IGL02970:Vmn1r62	APN	7	5,678,567 (GRCm39)	missense	possibly damaging	0.64
IGL03282:Vmn1r62	APN	7	5,678,547 (GRCm39)	missense	possibly damaging	0.93
R0470:Vmn1r62	UTSW	7	5,679,066 (GRCm39)	nonsense	probably null
R1416:Vmn1r62	UTSW	7	5,678,904 (GRCm39)	missense	probably damaging	1.00
R2149:Vmn1r62	UTSW	7	5,678,358 (GRCm39)	missense	probably benign	0.18
R4093:Vmn1r62	UTSW	7	5,678,943 (GRCm39)	missense	probably damaging	0.96
R4596:Vmn1r62	UTSW	7	5,678,306 (GRCm39)	start gained	probably benign
R4809:Vmn1r62	UTSW	7	5,678,866 (GRCm39)	missense	probably benign	0.41
R5669:Vmn1r62	UTSW	7	5,678,736 (GRCm39)	nonsense	probably null
R6262:Vmn1r62	UTSW	7	5,678,556 (GRCm39)	missense	probably damaging	1.00
R6312:Vmn1r62	UTSW	7	5,679,083 (GRCm39)	missense	possibly damaging	0.82
R6548:Vmn1r62	UTSW	7	5,678,769 (GRCm39)	missense	probably damaging	1.00
R7624:Vmn1r62	UTSW	7	5,678,600 (GRCm39)	missense	probably benign	0.01
R7710:Vmn1r62	UTSW	7	5,678,182 (GRCm39)	start gained	probably benign
R7896:Vmn1r62	UTSW	7	5,678,609 (GRCm39)	missense	probably damaging	1.00
R8117:Vmn1r62	UTSW	7	5,678,726 (GRCm39)	missense	possibly damaging	0.62
R8673:Vmn1r62	UTSW	7	5,678,277 (GRCm39)	start gained	probably benign
R8714:Vmn1r62	UTSW	7	5,678,629 (GRCm39)	nonsense	probably null
R8962:Vmn1r62	UTSW	7	5,678,601 (GRCm39)	missense	probably damaging	0.99
R9133:Vmn1r62	UTSW	7	5,679,062 (GRCm39)	missense	probably benign	0.01
R9246:Vmn1r62	UTSW	7	5,678,628 (GRCm39)	missense	probably damaging	1.00
R9360:Vmn1r62	UTSW	7	5,678,952 (GRCm39)	missense	probably damaging	0.99
RF007:Vmn1r62	UTSW	7	5,678,669 (GRCm39)	missense	probably benign	0.00

Posted On

2013-10-07