Incidental Mutation 'IGL01337:Trim75'
| ID |
74664 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Trim75
|
| Ensembl Gene |
ENSMUSG00000071089 |
| Gene Name |
tripartite motif-containing 75 |
| Synonyms |
LOC333307 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.226)
|
| Stock # |
IGL01337
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
65434303-65440296 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 65436387 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 21
(D21G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092932
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095295]
[ENSMUST00000210982]
|
| AlphaFold |
Q3UWZ0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000095295
AA Change: D21G
PolyPhen 2
Score 0.614 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000092932
Gene: ENSMUSG00000071089
AA Change: D21G
| Domain | Start | End | E-Value | Type |
|---|
|
RING
|
16 |
56 |
5.1e-11 |
SMART |
|
BBOX
|
90 |
131 |
1.61e-8 |
SMART |
|
coiled coil region
|
166 |
199 |
N/A |
INTRINSIC |
|
PRY
|
293 |
344 |
2.12e-8 |
SMART |
|
Pfam:SPRY
|
347 |
459 |
3.9e-14 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000210982
AA Change: D21G
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2m |
T |
C |
6: 121,645,529 (GRCm39) |
Y1025H |
probably damaging |
Het |
| Adarb2 |
T |
C |
13: 8,620,282 (GRCm39) |
L256P |
probably benign |
Het |
| Arsj |
A |
G |
3: 126,158,763 (GRCm39) |
Y114C |
probably damaging |
Het |
| Bdp1 |
G |
A |
13: 100,192,700 (GRCm39) |
P1378L |
probably benign |
Het |
| Clca3a2 |
T |
C |
3: 144,800,939 (GRCm39) |
Y138C |
probably damaging |
Het |
| Dsp |
G |
A |
13: 38,376,663 (GRCm39) |
D1483N |
probably benign |
Het |
| Etl4 |
T |
C |
2: 20,790,198 (GRCm39) |
S617P |
probably benign |
Het |
| Fbxo34 |
T |
C |
14: 47,767,674 (GRCm39) |
S345P |
probably benign |
Het |
| Gm5420 |
A |
G |
10: 21,567,514 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr182 |
T |
A |
10: 127,586,655 (GRCm39) |
I99F |
possibly damaging |
Het |
| Hectd1 |
A |
G |
12: 51,849,057 (GRCm39) |
I349T |
possibly damaging |
Het |
| Kifc5b |
A |
G |
17: 27,143,718 (GRCm39) |
T497A |
possibly damaging |
Het |
| Mllt3 |
A |
C |
4: 87,759,057 (GRCm39) |
D330E |
probably damaging |
Het |
| Mpp3 |
T |
C |
11: 101,891,411 (GRCm39) |
T576A |
probably benign |
Het |
| Mroh2b |
A |
G |
15: 4,934,506 (GRCm39) |
M126V |
probably benign |
Het |
| Naalad2 |
T |
G |
9: 18,238,669 (GRCm39) |
D644A |
probably damaging |
Het |
| Or4a74 |
A |
G |
2: 89,439,720 (GRCm39) |
I242T |
probably damaging |
Het |
| Otof |
C |
A |
5: 30,563,121 (GRCm39) |
A242S |
possibly damaging |
Het |
| Otof |
T |
C |
5: 30,576,856 (GRCm39) |
D132G |
probably benign |
Het |
| Pdk4 |
T |
A |
6: 5,491,869 (GRCm39) |
M68L |
probably benign |
Het |
| Ptprf |
A |
G |
4: 118,093,488 (GRCm39) |
Y385H |
probably damaging |
Het |
| Rxrb |
A |
G |
17: 34,255,605 (GRCm39) |
N254S |
probably damaging |
Het |
| Samd5 |
T |
A |
10: 9,504,768 (GRCm39) |
Y162F |
probably benign |
Het |
| Sapcd2 |
A |
G |
2: 25,266,491 (GRCm39) |
*392W |
probably null |
Het |
| Senp6 |
T |
C |
9: 80,043,792 (GRCm39) |
Y635H |
probably damaging |
Het |
| Serpine1 |
C |
A |
5: 137,098,185 (GRCm39) |
V163L |
probably damaging |
Het |
| Slc15a1 |
T |
C |
14: 121,698,091 (GRCm39) |
E678G |
possibly damaging |
Het |
| Slc22a16 |
T |
C |
10: 40,471,310 (GRCm39) |
F494L |
possibly damaging |
Het |
| Slc5a12 |
T |
A |
2: 110,450,718 (GRCm39) |
C304* |
probably null |
Het |
| Spink1 |
G |
A |
18: 43,870,216 (GRCm39) |
|
probably benign |
Het |
| Star |
G |
A |
8: 26,299,892 (GRCm39) |
G78E |
probably damaging |
Het |
| Stx1a |
T |
C |
5: 135,074,518 (GRCm39) |
I203T |
probably damaging |
Het |
| Tap2 |
A |
G |
17: 34,424,386 (GRCm39) |
|
probably benign |
Het |
| Vmn1r62 |
T |
A |
7: 5,679,144 (GRCm39) |
I275N |
probably damaging |
Het |
|
| Other mutations in Trim75 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02959:Trim75
|
APN |
8 |
65,435,417 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL03026:Trim75
|
APN |
8 |
65,436,438 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03155:Trim75
|
APN |
8 |
65,435,992 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL03228:Trim75
|
APN |
8 |
65,436,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03241:Trim75
|
APN |
8 |
65,435,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0089:Trim75
|
UTSW |
8 |
65,435,580 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0413:Trim75
|
UTSW |
8 |
65,435,892 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0523:Trim75
|
UTSW |
8 |
65,436,442 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1675:Trim75
|
UTSW |
8 |
65,435,163 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1721:Trim75
|
UTSW |
8 |
65,435,391 (GRCm39) |
splice site |
probably null |
|
|
R3861:Trim75
|
UTSW |
8 |
65,435,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4196:Trim75
|
UTSW |
8 |
65,435,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4469:Trim75
|
UTSW |
8 |
65,436,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4740:Trim75
|
UTSW |
8 |
65,435,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Trim75
|
UTSW |
8 |
65,435,091 (GRCm39) |
splice site |
probably null |
|
|
R6046:Trim75
|
UTSW |
8 |
65,435,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6227:Trim75
|
UTSW |
8 |
65,435,748 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6254:Trim75
|
UTSW |
8 |
65,436,094 (GRCm39) |
nonsense |
probably null |
|
|
R6444:Trim75
|
UTSW |
8 |
65,435,488 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7363:Trim75
|
UTSW |
8 |
65,435,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7936:Trim75
|
UTSW |
8 |
65,435,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9328:Trim75
|
UTSW |
8 |
65,435,315 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9453:Trim75
|
UTSW |
8 |
65,436,561 (GRCm39) |
start gained |
probably benign |
|
|
X0019:Trim75
|
UTSW |
8 |
65,436,183 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Trim75
|
UTSW |
8 |
65,435,593 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1177:Trim75
|
UTSW |
8 |
65,435,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-10-07 |
Incidental Mutation