Incidental Mutation 'IGL01337:Trim75'
ID74664
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim75
Ensembl Gene ENSMUSG00000071089
Gene Nametripartite motif-containing 75
SynonymsLOC333307
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.200) question?
Stock #IGL01337
Quality Score
Status
Chromosome8
Chromosomal Location64980884-64987831 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 64983735 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 21 (D21G)
Ref Sequence ENSEMBL: ENSMUSP00000092932 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095295] [ENSMUST00000210982]
Predicted Effect possibly damaging
Transcript: ENSMUST00000095295
AA Change: D21G

PolyPhen 2 Score 0.614 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000092932
Gene: ENSMUSG00000071089
AA Change: D21G

DomainStartEndE-ValueType
RING 16 56 5.1e-11 SMART
BBOX 90 131 1.61e-8 SMART
coiled coil region 166 199 N/A INTRINSIC
PRY 293 344 2.12e-8 SMART
Pfam:SPRY 347 459 3.9e-14 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000210982
AA Change: D21G
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,668,570 Y1025H probably damaging Het
Adarb2 T C 13: 8,570,246 L256P probably benign Het
Arsj A G 3: 126,365,114 Y114C probably damaging Het
Bdp1 G A 13: 100,056,192 P1378L probably benign Het
Clca2 T C 3: 145,095,178 Y138C probably damaging Het
Dsp G A 13: 38,192,687 D1483N probably benign Het
Etl4 T C 2: 20,785,387 S617P probably benign Het
Fbxo34 T C 14: 47,530,217 S345P probably benign Het
Gm5420 A G 10: 21,691,615 noncoding transcript Het
Gpr182 T A 10: 127,750,786 I99F possibly damaging Het
Hectd1 A G 12: 51,802,274 I349T possibly damaging Het
Kifc5b A G 17: 26,924,744 T497A possibly damaging Het
Mllt3 A C 4: 87,840,820 D330E probably damaging Het
Mpp3 T C 11: 102,000,585 T576A probably benign Het
Mroh2b A G 15: 4,905,024 M126V probably benign Het
Naalad2 T G 9: 18,327,373 D644A probably damaging Het
Olfr1247 A G 2: 89,609,376 I242T probably damaging Het
Otof C A 5: 30,405,777 A242S possibly damaging Het
Otof T C 5: 30,419,512 D132G probably benign Het
Pdk4 T A 6: 5,491,869 M68L probably benign Het
Ptprf A G 4: 118,236,291 Y385H probably damaging Het
Rxrb A G 17: 34,036,631 N254S probably damaging Het
Samd5 T A 10: 9,629,024 Y162F probably benign Het
Sapcd2 A G 2: 25,376,479 *392W probably null Het
Senp6 T C 9: 80,136,510 Y635H probably damaging Het
Serpine1 C A 5: 137,069,331 V163L probably damaging Het
Slc15a1 T C 14: 121,460,679 E678G possibly damaging Het
Slc22a16 T C 10: 40,595,314 F494L possibly damaging Het
Slc5a12 T A 2: 110,620,373 C304* probably null Het
Spink1 G A 18: 43,737,151 probably benign Het
Star G A 8: 25,809,864 G78E probably damaging Het
Stx1a T C 5: 135,045,664 I203T probably damaging Het
Tap2 A G 17: 34,205,412 probably benign Het
Vmn1r62 T A 7: 5,676,145 I275N probably damaging Het
Other mutations in Trim75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02959:Trim75 APN 8 64982765 missense possibly damaging 0.71
IGL03026:Trim75 APN 8 64983786 missense probably benign 0.01
IGL03155:Trim75 APN 8 64983340 missense possibly damaging 0.91
IGL03228:Trim75 APN 8 64983354 missense probably benign 0.00
IGL03241:Trim75 APN 8 64982706 missense probably damaging 1.00
R0089:Trim75 UTSW 8 64982928 missense possibly damaging 0.92
R0413:Trim75 UTSW 8 64983240 missense probably benign 0.26
R0523:Trim75 UTSW 8 64983790 missense probably benign 0.05
R1675:Trim75 UTSW 8 64982511 missense probably damaging 0.99
R1721:Trim75 UTSW 8 64982739 splice site probably null
R3861:Trim75 UTSW 8 64982827 missense probably damaging 1.00
R4196:Trim75 UTSW 8 64982764 missense probably damaging 1.00
R4469:Trim75 UTSW 8 64983717 missense probably damaging 1.00
R4740:Trim75 UTSW 8 64982547 missense probably damaging 1.00
R5049:Trim75 UTSW 8 64982439 splice site probably null
R6046:Trim75 UTSW 8 64982883 missense probably damaging 1.00
R6227:Trim75 UTSW 8 64983096 missense probably benign 0.30
R6254:Trim75 UTSW 8 64983442 nonsense probably null
R6444:Trim75 UTSW 8 64982836 missense possibly damaging 0.88
R7363:Trim75 UTSW 8 64982887 missense probably damaging 1.00
R7936:Trim75 UTSW 8 64982538 missense probably damaging 1.00
X0019:Trim75 UTSW 8 64983531 missense probably benign 0.00
Z1177:Trim75 UTSW 8 64982661 missense probably damaging 1.00
Z1177:Trim75 UTSW 8 64982941 missense probably damaging 0.96
Posted On2013-10-07