Incidental Mutation 'IGL01337:Kifc5b'
ID74679
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kifc5b
Ensembl Gene ENSMUSG00000024301
Gene Namekinesin family member C5B
Synonymskinesin family c-terminal 5B
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.362) question?
Stock #IGL01337
Quality Score
Status
Chromosome17
Chromosomal Location26917091-26932579 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 26924744 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 497 (T497A)
Ref Sequence ENSEMBL: ENSMUSP00000077984 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078961]
Predicted Effect possibly damaging
Transcript: ENSMUST00000078961
AA Change: T497A

PolyPhen 2 Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000077984
Gene: ENSMUSG00000024301
AA Change: T497A

DomainStartEndE-ValueType
low complexity region 25 36 N/A INTRINSIC
low complexity region 108 117 N/A INTRINSIC
low complexity region 222 240 N/A INTRINSIC
KISc 307 670 1.34e-143 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184919
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,668,570 Y1025H probably damaging Het
Adarb2 T C 13: 8,570,246 L256P probably benign Het
Arsj A G 3: 126,365,114 Y114C probably damaging Het
Bdp1 G A 13: 100,056,192 P1378L probably benign Het
Clca2 T C 3: 145,095,178 Y138C probably damaging Het
Dsp G A 13: 38,192,687 D1483N probably benign Het
Etl4 T C 2: 20,785,387 S617P probably benign Het
Fbxo34 T C 14: 47,530,217 S345P probably benign Het
Gm5420 A G 10: 21,691,615 noncoding transcript Het
Gpr182 T A 10: 127,750,786 I99F possibly damaging Het
Hectd1 A G 12: 51,802,274 I349T possibly damaging Het
Mllt3 A C 4: 87,840,820 D330E probably damaging Het
Mpp3 T C 11: 102,000,585 T576A probably benign Het
Mroh2b A G 15: 4,905,024 M126V probably benign Het
Naalad2 T G 9: 18,327,373 D644A probably damaging Het
Olfr1247 A G 2: 89,609,376 I242T probably damaging Het
Otof C A 5: 30,405,777 A242S possibly damaging Het
Otof T C 5: 30,419,512 D132G probably benign Het
Pdk4 T A 6: 5,491,869 M68L probably benign Het
Ptprf A G 4: 118,236,291 Y385H probably damaging Het
Rxrb A G 17: 34,036,631 N254S probably damaging Het
Samd5 T A 10: 9,629,024 Y162F probably benign Het
Sapcd2 A G 2: 25,376,479 *392W probably null Het
Senp6 T C 9: 80,136,510 Y635H probably damaging Het
Serpine1 C A 5: 137,069,331 V163L probably damaging Het
Slc15a1 T C 14: 121,460,679 E678G possibly damaging Het
Slc22a16 T C 10: 40,595,314 F494L possibly damaging Het
Slc5a12 T A 2: 110,620,373 C304* probably null Het
Spink1 G A 18: 43,737,151 probably benign Het
Star G A 8: 25,809,864 G78E probably damaging Het
Stx1a T C 5: 135,045,664 I203T probably damaging Het
Tap2 A G 17: 34,205,412 probably benign Het
Trim75 T C 8: 64,983,735 D21G possibly damaging Het
Vmn1r62 T A 7: 5,676,145 I275N probably damaging Het
Other mutations in Kifc5b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01886:Kifc5b APN 17 26932117 missense probably damaging 0.99
FR4449:Kifc5b UTSW 17 26924217 missense probably benign
R0394:Kifc5b UTSW 17 26923082 missense probably benign 0.37
R0800:Kifc5b UTSW 17 26923184 missense probably benign 0.01
R0890:Kifc5b UTSW 17 26923022 missense possibly damaging 0.67
R1122:Kifc5b UTSW 17 26924061 missense probably benign 0.01
R1651:Kifc5b UTSW 17 26925530 missense probably damaging 1.00
R1875:Kifc5b UTSW 17 26917290 splice site probably null
R1955:Kifc5b UTSW 17 26926297 critical splice donor site probably null
R2279:Kifc5b UTSW 17 26925541 missense probably damaging 0.99
R4921:Kifc5b UTSW 17 26921023 missense probably damaging 1.00
R4949:Kifc5b UTSW 17 26925514 missense probably damaging 1.00
R5044:Kifc5b UTSW 17 26924787 missense probably damaging 1.00
R6144:Kifc5b UTSW 17 26921852 missense probably benign 0.01
R6393:Kifc5b UTSW 17 26921842 missense probably benign 0.08
R6484:Kifc5b UTSW 17 26924772 missense probably damaging 1.00
R7075:Kifc5b UTSW 17 26925898 missense probably benign 0.30
R7385:Kifc5b UTSW 17 26925623 missense probably damaging 1.00
R7743:Kifc5b UTSW 17 26924202 missense probably damaging 1.00
Posted On2013-10-07