Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01339:Tdrd9'

74746

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tdrd9

Ensembl Gene

ENSMUSG00000054003

Gene Name

tudor domain containing 9

Synonyms

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.297) question?

Stock #

IGL01339

Quality Score

Status

Chromosome

Chromosomal Location

111971559-112068854 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 112040434 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 911 (V911M)

Ref Sequence

ENSEMBL: ENSMUSP00000078022 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079009]

Predicted Effect

probably damaging
Transcript: ENSMUST00000079009
AA Change: V911M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000078022
Gene: ENSMUSG00000054003
AA Change: V911M

Domain	Start	End	E-Value	Type
low complexity region	29	40	N/A	INTRINSIC
low complexity region	70	81	N/A	INTRINSIC
DEXDc	132	327	5.64e-21	SMART
HELICc	404	502	3.22e-16	SMART
low complexity region	547	561	N/A	INTRINSIC
HA2	565	666	1.9e-20	SMART
TUDOR	944	1003	1.52e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000191808

Predicted Effect

probably benign
Transcript: ENSMUST00000192125

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193586

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Male homozygous mice are sterile, displaying small testis, arrest of male meiosis and abnormal spermatocyte morphology. Females are fertile. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bahcc1	A	G	11: 120,289,512	T2565A	probably damaging	Het
C8a	A	C	4: 104,827,985	F354V	probably benign	Het
Cadps	C	T	14: 12,486,543	V876M	possibly damaging	Het
Chmp7	A	T	14: 69,719,406	I351N	probably damaging	Het
Clec7a	A	T	6: 129,465,486	W193R	probably damaging	Het
Clint1	T	C	11: 45,909,019	V535A	probably benign	Het
Clu	A	G	14: 65,975,588	E141G	probably damaging	Het
Cmah	A	T	13: 24,430,549	D159V	probably damaging	Het
Cntn2	A	T	1: 132,518,905		probably null	Het
Cox6a1	C	A	5: 115,345,839		probably benign	Het
Cyp2d10	C	T	15: 82,403,841	A195T	probably benign	Het
Dnah10	G	T	5: 124,777,212	K1901N	probably damaging	Het
Dopey1	G	A	9: 86,551,677	D2329N	possibly damaging	Het
Eipr1	A	G	12: 28,864,771	E308G	probably damaging	Het
Exoc4	T	C	6: 33,305,400		probably benign	Het
Fancd2	A	G	6: 113,553,752	I449V	probably benign	Het
Fbn2	T	C	18: 58,113,370	T487A	possibly damaging	Het
Fbxo40	T	C	16: 36,970,454	E98G	probably damaging	Het
Folh1	G	A	7: 86,726,098	T527I	probably damaging	Het
Gls	C	T	1: 52,188,708	D217N	probably damaging	Het
Gm6994	A	G	14: 77,481,178		probably benign	Het
Gpr149	A	T	3: 62,604,297	W94R	probably damaging	Het
Gpr158	A	G	2: 21,369,031	D259G	possibly damaging	Het
Hcn2	T	C	10: 79,729,068	L438P	probably damaging	Het
Hgd	A	C	16: 37,631,730	T374P	possibly damaging	Het
Ints3	A	G	3: 90,415,156		probably null	Het
Kctd5	A	T	17: 24,057,775	V172E	probably damaging	Het
Lmcd1	A	G	6: 112,310,625	I91V	probably benign	Het
Lrrc37a	A	G	11: 103,497,937	S2221P	unknown	Het
Ltk	T	A	2: 119,752,974	D310V	probably damaging	Het
Luzp1	T	A	4: 136,542,776	M770K	probably damaging	Het
Mxd4	G	A	5: 34,184,346		probably benign	Het
Mzb1	T	A	18: 35,648,346	H71L	probably benign	Het
Necap2	G	A	4: 141,074,965	T63I	probably benign	Het
Nefl	A	G	14: 68,086,482		probably benign	Het
Odam	G	A	5: 87,885,896		probably null	Het
Pcdh18	A	G	3: 49,755,798	I356T	probably benign	Het
Pcx	T	A	19: 4,620,235		probably null	Het
Pde2a	T	C	7: 101,507,159	S593P	probably benign	Het
Rapgef3	A	T	15: 97,758,059	L359M	probably damaging	Het
Rb1	T	C	14: 73,264,371		probably null	Het
Rbm44	A	G	1: 91,168,964	I976V	probably benign	Het
Rdh13	A	T	7: 4,427,624	S278R	probably damaging	Het
Rgma	A	G	7: 73,417,483	E256G	probably damaging	Het
Rnf112	A	T	11: 61,450,477	D402E	probably benign	Het
Rnps1	T	A	17: 24,422,299	D224E	probably damaging	Het
Scn10a	C	T	9: 119,622,766	V1364M	probably damaging	Het
Scn1a	C	T	2: 66,325,960	R535H	probably benign	Het
Scn8a	A	T	15: 101,032,201	D1431V	probably benign	Het
Setdb1	A	T	3: 95,338,580	L677*	probably null	Het
Slc17a8	T	A	10: 89,591,244	I148F	probably damaging	Het
Slx4ip	T	A	2: 137,044,055	C98*	probably null	Het
Sptbn2	T	G	19: 4,745,972	Y1726*	probably null	Het
Tcof1	T	C	18: 60,818,095		probably benign	Het
Tdrd3	G	A	14: 87,480,794	V210I	possibly damaging	Het
Tmod4	G	A	3: 95,128,297	R252H	probably benign	Het
Tti1	G	T	2: 158,009,130	P63Q	possibly damaging	Het
Tuft1	A	T	3: 94,628,287	D109E	probably damaging	Het
Wdr63	T	C	3: 146,042,836	Y841C	probably benign	Het
Zcchc2	T	C	1: 106,029,775	S659P	probably damaging	Het

Other mutations in Tdrd9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01373:Tdrd9	APN	12	112040434	missense	probably damaging	1.00
IGL01542:Tdrd9	APN	12	112046989	missense	possibly damaging	0.94
IGL02967:Tdrd9	APN	12	111992488	missense	possibly damaging	0.50
IGL03063:Tdrd9	APN	12	112044299	missense	probably benign	0.00
IGL03107:Tdrd9	APN	12	112042840	missense	probably damaging	0.98
R0433:Tdrd9	UTSW	12	112025581	nonsense	probably null
R0453:Tdrd9	UTSW	12	112068239	missense	probably benign
R0655:Tdrd9	UTSW	12	112040465	missense	probably damaging	1.00
R0666:Tdrd9	UTSW	12	112007580	intron	probably benign
R1073:Tdrd9	UTSW	12	112023259	missense	probably damaging	1.00
R1280:Tdrd9	UTSW	12	112039408	missense	probably damaging	1.00
R1386:Tdrd9	UTSW	12	112044804	missense	probably benign	0.21
R1521:Tdrd9	UTSW	12	112036410	missense	probably damaging	1.00
R1601:Tdrd9	UTSW	12	112023253	nonsense	probably null
R1651:Tdrd9	UTSW	12	112024706	missense	probably damaging	0.97
R1715:Tdrd9	UTSW	12	112036439	missense	possibly damaging	0.62
R1854:Tdrd9	UTSW	12	112044812	missense	probably damaging	1.00
R1905:Tdrd9	UTSW	12	112063627	splice site	probably benign
R2386:Tdrd9	UTSW	12	112015900	missense	probably damaging	1.00
R2863:Tdrd9	UTSW	12	112031261	missense	probably benign
R2915:Tdrd9	UTSW	12	112040461	missense	probably damaging	1.00
R2958:Tdrd9	UTSW	12	112041672	missense	probably damaging	0.97
R4033:Tdrd9	UTSW	12	111992539	missense	possibly damaging	0.58
R4087:Tdrd9	UTSW	12	112013486	nonsense	probably null
R4237:Tdrd9	UTSW	12	112067625	nonsense	probably null
R4482:Tdrd9	UTSW	12	112014501	critical splice donor site	probably null
R4501:Tdrd9	UTSW	12	112042809	missense	probably benign	0.00
R4502:Tdrd9	UTSW	12	111993825	missense	probably damaging	1.00
R4715:Tdrd9	UTSW	12	112041689	missense	probably benign	0.00
R4803:Tdrd9	UTSW	12	111996835	nonsense	probably null
R5218:Tdrd9	UTSW	12	112063475	intron	probably benign
R5275:Tdrd9	UTSW	12	112051912	nonsense	probably null
R5295:Tdrd9	UTSW	12	112051912	nonsense	probably null
R5301:Tdrd9	UTSW	12	112036529	critical splice donor site	probably null
R5339:Tdrd9	UTSW	12	112027122	missense	probably damaging	1.00
R5500:Tdrd9	UTSW	12	112023268	missense	probably benign	0.02
R5573:Tdrd9	UTSW	12	111997902	synonymous	probably null
R5590:Tdrd9	UTSW	12	112051980	missense	probably benign	0.01
R5891:Tdrd9	UTSW	12	112042719	missense	probably damaging	1.00
R6056:Tdrd9	UTSW	12	111985041	missense	probably damaging	1.00
R6057:Tdrd9	UTSW	12	112013286	missense	possibly damaging	0.85
R6125:Tdrd9	UTSW	12	112068198	missense	possibly damaging	0.89
R6254:Tdrd9	UTSW	12	112025900	splice site	probably null
R6335:Tdrd9	UTSW	12	112041752	critical splice donor site	probably null
R6345:Tdrd9	UTSW	12	112034608	missense	probably damaging	0.99
R6792:Tdrd9	UTSW	12	112027113	missense	probably benign	0.01
R6956:Tdrd9	UTSW	12	112036354	splice site	probably benign
R6987:Tdrd9	UTSW	12	112025593	missense	possibly damaging	0.82
R7090:Tdrd9	UTSW	12	111992470	missense	probably benign
R7158:Tdrd9	UTSW	12	112036366	missense	probably benign	0.08
R7220:Tdrd9	UTSW	12	112014454	missense	probably damaging	1.00
R7478:Tdrd9	UTSW	12	111985042	missense	probably damaging	1.00
R7489:Tdrd9	UTSW	12	112067637	missense	probably benign	0.00
X0018:Tdrd9	UTSW	12	112039329	missense	probably benign	0.24

Posted On

2013-10-07