Incidental Mutation 'IGL01343:Adgrf1'
ID74918
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adgrf1
Ensembl Gene ENSMUSG00000041293
Gene Nameadhesion G protein-coupled receptor F1
SynonymsGpr110, 5031409J19Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01343
Quality Score
Status
Chromosome17
Chromosomal Location43270329-43324737 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 43313195 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 835 (F835L)
Ref Sequence ENSEMBL: ENSMUSP00000049380 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047399]
Predicted Effect probably null
Transcript: ENSMUST00000047399
AA Change: F835L

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000049380
Gene: ENSMUSG00000041293
AA Change: F835L

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
low complexity region 59 83 N/A INTRINSIC
Pfam:SEA 150 238 3.7e-10 PFAM
low complexity region 341 363 N/A INTRINSIC
GPS 528 576 5.56e-15 SMART
Pfam:7tm_2 580 832 2.1e-38 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a reporter allele exhibit normal viability and fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik A G 7: 28,150,702 Q1191R probably benign Het
Abcd2 A T 15: 91,149,213 probably benign Het
Akp3 G T 1: 87,127,136 probably benign Het
BC106179 G T 16: 23,224,287 probably benign Het
Bysl C A 17: 47,601,889 M325I probably benign Het
C330027C09Rik A G 16: 49,013,188 I551V probably damaging Het
Crnn A G 3: 93,148,326 R140G probably benign Het
Cts8 T C 13: 61,249,196 probably benign Het
Cxcr4 T C 1: 128,589,555 Y121C probably damaging Het
Ddr2 T C 1: 169,984,581 T691A probably benign Het
Dhx30 A T 9: 110,086,245 F782I probably benign Het
Efcab5 C T 11: 77,129,930 G655D probably damaging Het
Eif2ak4 G A 2: 118,422,089 V381I probably benign Het
Enpp3 A T 10: 24,805,922 Y295* probably null Het
Fbxo28 T C 1: 182,317,012 E329G probably damaging Het
Fmnl2 T A 2: 53,123,545 V972D probably damaging Het
Fmr1 A G X: 68,688,295 D22G probably damaging Het
Fsip2 A G 2: 82,999,819 T6886A possibly damaging Het
Gadl1 A G 9: 116,074,112 *503W probably null Het
Gpc6 A T 14: 117,186,812 K104I possibly damaging Het
Hecw2 T A 1: 53,826,976 T1509S probably damaging Het
Lonp1 A G 17: 56,615,586 L680P possibly damaging Het
Lrrc66 A T 5: 73,608,463 N412K probably damaging Het
Marco C T 1: 120,494,740 probably null Het
Mdga2 T C 12: 66,723,109 T206A probably damaging Het
Mogat2 C A 7: 99,232,568 A54S possibly damaging Het
Myh15 T A 16: 49,155,677 D1369E probably benign Het
Nckap1 A T 2: 80,519,842 S840T possibly damaging Het
Ncor1 C T 11: 62,325,486 probably null Het
Nfrkb C A 9: 31,388,954 L14I probably damaging Het
Notch1 C A 2: 26,472,905 A950S probably benign Het
Notch3 T C 17: 32,143,436 E1405G probably benign Het
Nsd2 C A 5: 33,843,578 D146E probably damaging Het
Oc90 T C 15: 65,889,591 T193A probably benign Het
Olfr1090 T A 2: 86,754,499 K80* probably null Het
Olfr1356 A T 10: 78,847,597 V106E probably damaging Het
Olfr150 C A 9: 39,737,715 A300D probably damaging Het
Orc2 A T 1: 58,492,855 probably null Het
Pacsin2 T C 15: 83,386,686 H254R probably damaging Het
Pif1 T A 9: 65,589,562 M319K probably damaging Het
Prag1 G A 8: 36,103,046 R261H possibly damaging Het
Ptprq G A 10: 107,638,839 T1335I probably damaging Het
Ryr3 A G 2: 112,660,054 Y3812H probably damaging Het
Sgo2b G A 8: 63,927,315 Q828* probably null Het
Skint6 A G 4: 113,283,626 V6A probably benign Het
Slc16a13 A G 11: 70,220,514 I55T probably damaging Het
Slc22a3 A T 17: 12,425,629 W490R probably damaging Het
Speer4b G T 5: 27,497,883 H208N probably benign Het
Tas2r124 T C 6: 132,755,415 L229S probably damaging Het
Tlr4 T C 4: 66,833,887 probably benign Het
Tmed1 G T 9: 21,510,073 T35K probably damaging Het
Tubgcp5 C A 7: 55,796,031 probably benign Het
Ugt2b34 A G 5: 86,904,388 S250P possibly damaging Het
Zfp516 A G 18: 82,993,096 T1085A probably damaging Het
Znfx1 T C 2: 167,037,363 I1698V probably benign Het
Zswim8 G T 14: 20,713,341 W385C probably damaging Het
Other mutations in Adgrf1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01359:Adgrf1 APN 17 43310686 missense probably damaging 0.99
IGL02131:Adgrf1 APN 17 43303747 missense probably damaging 0.99
IGL02692:Adgrf1 APN 17 43303778 missense probably damaging 1.00
IGL02891:Adgrf1 APN 17 43311161 missense probably damaging 0.96
IGL03027:Adgrf1 APN 17 43296714 missense probably damaging 1.00
IGL03296:Adgrf1 APN 17 43321153 splice site probably benign
R0211:Adgrf1 UTSW 17 43296690 missense probably damaging 1.00
R0211:Adgrf1 UTSW 17 43296690 missense probably damaging 1.00
R0389:Adgrf1 UTSW 17 43303788 critical splice donor site probably null
R0488:Adgrf1 UTSW 17 43310411 missense probably damaging 0.99
R1591:Adgrf1 UTSW 17 43310981 missense probably damaging 1.00
R1817:Adgrf1 UTSW 17 43310033 missense probably benign 0.01
R1819:Adgrf1 UTSW 17 43310033 missense probably benign 0.01
R2009:Adgrf1 UTSW 17 43321221 nonsense probably null
R2032:Adgrf1 UTSW 17 43311275 missense probably damaging 1.00
R2140:Adgrf1 UTSW 17 43300802 missense probably damaging 0.99
R3953:Adgrf1 UTSW 17 43310207 missense probably benign 0.08
R4679:Adgrf1 UTSW 17 43310493 missense probably damaging 1.00
R4775:Adgrf1 UTSW 17 43311163 missense probably damaging 1.00
R4858:Adgrf1 UTSW 17 43303672 missense probably damaging 1.00
R4894:Adgrf1 UTSW 17 43299084 nonsense probably null
R4895:Adgrf1 UTSW 17 43310620 missense probably benign 0.33
R4935:Adgrf1 UTSW 17 43295239 missense probably benign 0.00
R5027:Adgrf1 UTSW 17 43303747 missense probably damaging 0.99
R5373:Adgrf1 UTSW 17 43291005 start gained probably benign
R5374:Adgrf1 UTSW 17 43291005 start gained probably benign
R5455:Adgrf1 UTSW 17 43321143 splice site probably null
R5579:Adgrf1 UTSW 17 43311064 missense probably damaging 1.00
R5985:Adgrf1 UTSW 17 43293255 missense probably benign 0.00
R6038:Adgrf1 UTSW 17 43295209 missense probably benign 0.00
R6038:Adgrf1 UTSW 17 43295209 missense probably benign 0.00
R6160:Adgrf1 UTSW 17 43310687 missense probably damaging 1.00
R6227:Adgrf1 UTSW 17 43310273 missense probably benign 0.05
R6500:Adgrf1 UTSW 17 43310372 missense probably damaging 1.00
R7066:Adgrf1 UTSW 17 43310260 missense probably benign 0.05
R7099:Adgrf1 UTSW 17 43310602 missense probably benign 0.00
R7561:Adgrf1 UTSW 17 43311109 missense possibly damaging 0.94
Posted On2013-10-07