Incidental Mutation 'IGL01343:Gadl1'
ID 74953
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gadl1
Ensembl Gene ENSMUSG00000056880
Gene Name glutamate decarboxylase-like 1
Synonyms 1110027M19Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # IGL01343
Quality Score
Status
Chromosome 9
Chromosomal Location 115713947-115905243 bp(+) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) A to G at 115903180 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Tryptophan at position 503 (*503W)
Ref Sequence ENSEMBL: ENSMUSP00000113240 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069651] [ENSMUST00000121770]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000069651
AA Change: *503W
SMART Domains Protein: ENSMUSP00000077694
Gene: ENSMUSG00000056880
AA Change: *503W

DomainStartEndE-ValueType
Pfam:Pyridoxal_deC 58 426 1.1e-113 PFAM
Pfam:Beta_elim_lyase 137 467 1e-7 PFAM
Pfam:Aminotran_5 167 333 1.6e-7 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000121770
AA Change: *503W
SMART Domains Protein: ENSMUSP00000113240
Gene: ENSMUSG00000056880
AA Change: *503W

DomainStartEndE-ValueType
Pfam:Pyridoxal_deC 58 426 2.8e-112 PFAM
Pfam:Beta_elim_lyase 137 461 6.2e-8 PFAM
Pfam:Aminotran_5 184 330 4.1e-7 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd2 A T 15: 91,033,416 (GRCm39) probably benign Het
Adgrf1 T A 17: 43,624,086 (GRCm39) F835L probably null Het
Akp3 G T 1: 87,054,858 (GRCm39) probably benign Het
BC106179 G T 16: 23,043,037 (GRCm39) probably benign Het
Bysl C A 17: 47,912,814 (GRCm39) M325I probably benign Het
Cip2a A G 16: 48,833,551 (GRCm39) I551V probably damaging Het
Crnn A G 3: 93,055,633 (GRCm39) R140G probably benign Het
Cts8 T C 13: 61,397,010 (GRCm39) probably benign Het
Cxcr4 T C 1: 128,517,292 (GRCm39) Y121C probably damaging Het
Ddr2 T C 1: 169,812,150 (GRCm39) T691A probably benign Het
Dhx30 A T 9: 109,915,313 (GRCm39) F782I probably benign Het
Efcab5 C T 11: 77,020,756 (GRCm39) G655D probably damaging Het
Eif2ak4 G A 2: 118,252,570 (GRCm39) V381I probably benign Het
Enpp3 A T 10: 24,681,820 (GRCm39) Y295* probably null Het
Fbxo28 T C 1: 182,144,577 (GRCm39) E329G probably damaging Het
Fcgbpl1 A G 7: 27,850,127 (GRCm39) Q1191R probably benign Het
Fmnl2 T A 2: 53,013,557 (GRCm39) V972D probably damaging Het
Fmr1 A G X: 67,731,901 (GRCm39) D22G probably damaging Het
Fsip2 A G 2: 82,830,163 (GRCm39) T6886A possibly damaging Het
Gpc6 A T 14: 117,424,224 (GRCm39) K104I possibly damaging Het
Hecw2 T A 1: 53,866,135 (GRCm39) T1509S probably damaging Het
Lonp1 A G 17: 56,922,586 (GRCm39) L680P possibly damaging Het
Lrrc66 A T 5: 73,765,806 (GRCm39) N412K probably damaging Het
Marco C T 1: 120,422,469 (GRCm39) probably null Het
Mdga2 T C 12: 66,769,883 (GRCm39) T206A probably damaging Het
Mogat2 C A 7: 98,881,775 (GRCm39) A54S possibly damaging Het
Myh15 T A 16: 48,976,040 (GRCm39) D1369E probably benign Het
Nckap1 A T 2: 80,350,186 (GRCm39) S840T possibly damaging Het
Ncor1 C T 11: 62,216,312 (GRCm39) probably null Het
Nfrkb C A 9: 31,300,250 (GRCm39) L14I probably damaging Het
Notch1 C A 2: 26,362,917 (GRCm39) A950S probably benign Het
Notch3 T C 17: 32,362,410 (GRCm39) E1405G probably benign Het
Nsd2 C A 5: 34,000,922 (GRCm39) D146E probably damaging Het
Oc90 T C 15: 65,761,440 (GRCm39) T193A probably benign Het
Or7c70 A T 10: 78,683,431 (GRCm39) V106E probably damaging Het
Or8g50 C A 9: 39,649,011 (GRCm39) A300D probably damaging Het
Or8k40 T A 2: 86,584,843 (GRCm39) K80* probably null Het
Orc2 A T 1: 58,532,014 (GRCm39) probably null Het
Pacsin2 T C 15: 83,270,887 (GRCm39) H254R probably damaging Het
Pif1 T A 9: 65,496,844 (GRCm39) M319K probably damaging Het
Prag1 G A 8: 36,570,200 (GRCm39) R261H possibly damaging Het
Ptprq G A 10: 107,474,700 (GRCm39) T1335I probably damaging Het
Ryr3 A G 2: 112,490,399 (GRCm39) Y3812H probably damaging Het
Sgo2b G A 8: 64,380,349 (GRCm39) Q828* probably null Het
Skint6 A G 4: 113,140,823 (GRCm39) V6A probably benign Het
Slc16a13 A G 11: 70,111,340 (GRCm39) I55T probably damaging Het
Slc22a3 A T 17: 12,644,516 (GRCm39) W490R probably damaging Het
Speer4b G T 5: 27,702,881 (GRCm39) H208N probably benign Het
Tas2r124 T C 6: 132,732,378 (GRCm39) L229S probably damaging Het
Tlr4 T C 4: 66,752,124 (GRCm39) probably benign Het
Tmed1 G T 9: 21,421,369 (GRCm39) T35K probably damaging Het
Tubgcp5 C A 7: 55,445,779 (GRCm39) probably benign Het
Ugt2b34 A G 5: 87,052,247 (GRCm39) S250P possibly damaging Het
Zfp516 A G 18: 83,011,221 (GRCm39) T1085A probably damaging Het
Znfx1 T C 2: 166,879,283 (GRCm39) I1698V probably benign Het
Zswim8 G T 14: 20,763,409 (GRCm39) W385C probably damaging Het
Other mutations in Gadl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01069:Gadl1 APN 9 115,783,907 (GRCm39) critical splice donor site probably null
IGL01693:Gadl1 APN 9 115,778,653 (GRCm39) missense probably damaging 1.00
IGL02106:Gadl1 APN 9 115,766,225 (GRCm39) utr 5 prime probably benign
IGL02740:Gadl1 APN 9 115,835,629 (GRCm39) nonsense probably null
IGL03063:Gadl1 APN 9 115,795,335 (GRCm39) missense probably damaging 1.00
IGL03104:Gadl1 APN 9 115,903,108 (GRCm39) missense possibly damaging 0.93
IGL03127:Gadl1 APN 9 115,777,732 (GRCm39) missense probably damaging 1.00
R0133:Gadl1 UTSW 9 115,770,411 (GRCm39) missense probably benign 0.00
R0285:Gadl1 UTSW 9 115,859,806 (GRCm39) splice site probably benign
R0737:Gadl1 UTSW 9 115,903,055 (GRCm39) missense probably damaging 0.99
R0771:Gadl1 UTSW 9 115,773,300 (GRCm39) missense probably damaging 1.00
R1522:Gadl1 UTSW 9 115,773,297 (GRCm39) missense probably damaging 1.00
R1716:Gadl1 UTSW 9 115,835,576 (GRCm39) nonsense probably null
R2061:Gadl1 UTSW 9 115,770,448 (GRCm39) missense probably damaging 1.00
R2163:Gadl1 UTSW 9 115,778,626 (GRCm39) missense possibly damaging 0.93
R3854:Gadl1 UTSW 9 115,835,732 (GRCm39) nonsense probably null
R3964:Gadl1 UTSW 9 115,794,676 (GRCm39) missense probably damaging 0.98
R4654:Gadl1 UTSW 9 115,770,408 (GRCm39) missense probably damaging 1.00
R4724:Gadl1 UTSW 9 115,783,685 (GRCm39) missense possibly damaging 0.81
R4765:Gadl1 UTSW 9 115,795,381 (GRCm39) missense probably null 0.00
R4956:Gadl1 UTSW 9 115,869,987 (GRCm39) missense probably benign 0.00
R5179:Gadl1 UTSW 9 115,789,448 (GRCm39) nonsense probably null
R5593:Gadl1 UTSW 9 115,835,718 (GRCm39) missense probably damaging 1.00
R5620:Gadl1 UTSW 9 115,766,230 (GRCm39) start codon destroyed probably benign 0.09
R6048:Gadl1 UTSW 9 115,835,769 (GRCm39) splice site probably null
R6458:Gadl1 UTSW 9 115,870,070 (GRCm39) makesense probably null
R7497:Gadl1 UTSW 9 115,903,155 (GRCm39) missense probably benign 0.00
R7889:Gadl1 UTSW 9 115,783,883 (GRCm39) missense possibly damaging 0.56
R8843:Gadl1 UTSW 9 115,835,569 (GRCm39) missense probably benign 0.00
R8858:Gadl1 UTSW 9 115,835,669 (GRCm39) missense probably damaging 1.00
R9015:Gadl1 UTSW 9 115,794,705 (GRCm39) missense probably benign 0.03
R9459:Gadl1 UTSW 9 115,794,679 (GRCm39) missense probably damaging 1.00
R9758:Gadl1 UTSW 9 115,789,519 (GRCm39) missense probably benign 0.09
Z1088:Gadl1 UTSW 9 115,766,338 (GRCm39) missense probably benign 0.00
Posted On 2013-10-07