Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01347:Or7a41'

75079

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or7a41

Ensembl Gene

ENSMUSG00000060205

Gene Name

olfactory receptor family 7 subfamily A member 41

Synonyms

MOR139-3, Olfr57, GA_x6K02T2QGN0-2777431-2776472, IF12

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL01347

Quality Score

Status

Chromosome

Chromosomal Location

78870557-78871636 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 78871445 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 272 (T272A)

Ref Sequence

ENSEMBL: ENSMUSP00000144814 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000082244] [ENSMUST00000203906]

AlphaFold

Q8VGU7

Predicted Effect

probably benign
Transcript: ENSMUST00000082244
AA Change: T272A

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000080872
Gene: ENSMUSG00000060205
AA Change: T272A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	308	2.2e-49	PFAM
Pfam:7tm_1	42	291	6e-28	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203906
AA Change: T272A

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: T272A

Domain	Start	End	E-Value	Type
low complexity region	9	19	N/A	INTRINSIC
Pfam:7tm_4	32	308	2e-49	PFAM
Pfam:7tm_1	42	291	1.9e-23	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aoc1l2	A	T	6: 48,909,477 (GRCm39)	Y574F	probably benign	Het
Apc	C	T	18: 34,450,723 (GRCm39)	P2506S	probably damaging	Het
Bdp1	T	A	13: 100,206,711 (GRCm39)	K610N	possibly damaging	Het
Bri3bp	T	G	5: 125,531,581 (GRCm39)	C176G	probably damaging	Het
Carnmt1	A	G	19: 18,668,818 (GRCm39)	I248V	probably benign	Het
Ccdc88b	A	G	19: 6,822,454 (GRCm39)	L1475P	probably damaging	Het
Cfap100	C	T	6: 90,383,103 (GRCm39)	V511M	possibly damaging	Het
Chchd3	T	C	6: 32,780,838 (GRCm39)	N78S	probably benign	Het
Cnnm4	G	A	1: 36,537,115 (GRCm39)	E480K	possibly damaging	Het
Cyp2d34	T	A	15: 82,500,978 (GRCm39)	I385F	possibly damaging	Het
D930048N14Rik	T	A	11: 51,545,615 (GRCm39)		probably benign	Het
Dgkg	A	T	16: 22,419,340 (GRCm39)	D53E	probably benign	Het
Dlx3	T	A	11: 95,011,359 (GRCm39)	L71H	probably damaging	Het
Egln2	A	C	7: 26,859,717 (GRCm39)	V332G	probably null	Het
Entpd2	A	G	2: 25,288,746 (GRCm39)	Q250R	probably benign	Het
Epyc	A	G	10: 97,510,593 (GRCm39)	D132G	probably damaging	Het
Fxr2	A	G	11: 69,543,114 (GRCm39)	D637G	probably benign	Het
Gapvd1	A	G	2: 34,596,708 (GRCm39)		probably null	Het
Gbp11	G	A	5: 105,479,194 (GRCm39)		probably benign	Het
Gm17175	A	T	14: 51,808,307 (GRCm39)	C162S	probably damaging	Het
Gm5499	C	T	17: 87,386,339 (GRCm39)		noncoding transcript	Het
Gps1	T	C	11: 120,679,086 (GRCm39)	V378A	probably benign	Het
Grik1	C	T	16: 87,754,481 (GRCm39)	R368Q	probably benign	Het
Gsap	A	G	5: 21,431,318 (GRCm39)	E214G	probably benign	Het
H2bc13	A	G	13: 21,900,064 (GRCm39)	Y84H	probably damaging	Het
Jdp2	T	C	12: 85,655,020 (GRCm39)	S28P	probably benign	Het
Kif26b	T	C	1: 178,698,240 (GRCm39)	F577S	probably damaging	Het
Kl	G	A	5: 150,904,130 (GRCm39)	G294D	probably damaging	Het
Lgsn	T	A	1: 31,243,041 (GRCm39)	D374E	probably damaging	Het
Lman1	T	C	18: 66,124,681 (GRCm39)	I353V	probably damaging	Het
Lmna	T	C	3: 88,392,270 (GRCm39)	H374R	probably benign	Het
Lrrc57	A	G	2: 120,439,286 (GRCm39)	S31P	probably benign	Het
Lum	T	A	10: 97,404,547 (GRCm39)	N147K	probably damaging	Het
Or6n2	T	C	1: 173,897,632 (GRCm39)	I256T	probably benign	Het
P4ha3	C	A	7: 99,955,140 (GRCm39)	L332I	probably damaging	Het
Pelp1	A	G	11: 70,286,505 (GRCm39)	I541T	probably damaging	Het
Pja2	A	C	17: 64,620,023 (GRCm39)	S2A	probably benign	Het
Rhbdl3	T	C	11: 80,244,268 (GRCm39)	L325P	probably damaging	Het
Robo2	T	C	16: 74,149,744 (GRCm39)	D28G	probably damaging	Het
Rpa1	A	G	11: 75,198,111 (GRCm39)	Y470H	probably damaging	Het
Rtn3	T	C	19: 7,434,645 (GRCm39)	N430S	probably benign	Het
Scg2	T	A	1: 79,414,538 (GRCm39)	I62L	probably benign	Het
Scn5a	T	A	9: 119,391,507 (GRCm39)	K62*	probably null	Het
Sec23ip	T	C	7: 128,364,129 (GRCm39)	V469A	probably benign	Het
Shank1	A	G	7: 43,991,544 (GRCm39)	T663A	unknown	Het
Slco1a7	A	T	6: 141,700,192 (GRCm39)	Y113*	probably null	Het
Stab2	G	T	10: 86,737,567 (GRCm39)		probably null	Het
Tmcc3	T	C	10: 94,418,147 (GRCm39)	L305P	probably damaging	Het
Tmem145	A	G	7: 25,014,260 (GRCm39)	N458S	probably damaging	Het
Tpr	G	A	1: 150,302,738 (GRCm39)	R1412Q	probably damaging	Het
Wdr1	A	T	5: 38,703,058 (GRCm39)	F173I	possibly damaging	Het
Wdr17	C	T	8: 55,104,380 (GRCm39)	V898I	probably benign	Het
Wdr64	A	T	1: 175,547,899 (GRCm39)	L145F	probably benign	Het
Wnt10b	A	G	15: 98,674,826 (GRCm39)		probably benign	Het
Zfyve26	A	T	12: 79,298,957 (GRCm39)		probably null	Het

Other mutations in Or7a41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02230:Or7a41	APN	10	78,870,876 (GRCm39)	missense	probably damaging	0.99
IGL02283:Or7a41	APN	10	78,871,379 (GRCm39)	missense	probably damaging	1.00
IGL02878:Or7a41	APN	10	78,871,392 (GRCm39)	missense	probably benign	0.23
IGL02975:Or7a41	APN	10	78,870,867 (GRCm39)	missense	possibly damaging	0.83
IGL03259:Or7a41	APN	10	78,871,234 (GRCm39)	nonsense	probably null
R1366:Or7a41	UTSW	10	78,870,876 (GRCm39)	missense	probably damaging	1.00
R1438:Or7a41	UTSW	10	78,871,122 (GRCm39)	missense	possibly damaging	0.88
R1528:Or7a41	UTSW	10	78,871,398 (GRCm39)	missense	probably damaging	0.96
R1601:Or7a41	UTSW	10	78,871,338 (GRCm39)	missense	possibly damaging	0.56
R2032:Or7a41	UTSW	10	78,871,163 (GRCm39)	missense	possibly damaging	0.86
R2112:Or7a41	UTSW	10	78,871,248 (GRCm39)	missense	probably damaging	1.00
R2382:Or7a41	UTSW	10	78,870,968 (GRCm39)	missense	possibly damaging	0.52
R2967:Or7a41	UTSW	10	78,870,887 (GRCm39)	missense	probably damaging	1.00
R3773:Or7a41	UTSW	10	78,871,014 (GRCm39)	missense	possibly damaging	0.95
R3940:Or7a41	UTSW	10	78,871,038 (GRCm39)	missense	probably damaging	1.00
R4405:Or7a41	UTSW	10	78,871,244 (GRCm39)	missense	probably benign
R5944:Or7a41	UTSW	10	78,871,223 (GRCm39)	missense	probably benign	0.00
R6563:Or7a41	UTSW	10	78,871,051 (GRCm39)	missense	possibly damaging	0.67
R6614:Or7a41	UTSW	10	78,870,925 (GRCm39)	nonsense	probably null
R7181:Or7a41	UTSW	10	78,871,287 (GRCm39)	missense	probably damaging	0.98
R7639:Or7a41	UTSW	10	78,871,206 (GRCm39)	missense	probably damaging	0.99
R9427:Or7a41	UTSW	10	78,871,395 (GRCm39)	missense	probably damaging	0.99
R9508:Or7a41	UTSW	10	78,870,933 (GRCm39)	missense	probably damaging	1.00
R9652:Or7a41	UTSW	10	78,871,230 (GRCm39)	missense	probably benign	0.05
R9681:Or7a41	UTSW	10	78,871,577 (GRCm39)	missense	probably benign
R9767:Or7a41	UTSW	10	78,870,765 (GRCm39)	missense	possibly damaging	0.78

Posted On

2013-10-07