Incidental Mutation 'IGL01347:Wnt10b'
ID 75093
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wnt10b
Ensembl Gene ENSMUSG00000022996
Gene Name wingless-type MMTV integration site family, member 10B
Synonyms Wnt12
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01347
Quality Score
Status
Chromosome 15
Chromosomal Location 98668593-98676031 bp(-) (GRCm39)
Type of Mutation utr 5 prime
DNA Base Change (assembly) A to G at 98674826 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000154394 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023732] [ENSMUST00000166022] [ENSMUST00000226610] [ENSMUST00000226655] [ENSMUST00000226846] [ENSMUST00000228546] [ENSMUST00000228594]
AlphaFold P48614
Predicted Effect unknown
Transcript: ENSMUST00000023732
AA Change: S7P
SMART Domains Protein: ENSMUSP00000023732
Gene: ENSMUSG00000022996
AA Change: S7P

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
WNT1 50 389 9.1e-128 SMART
Predicted Effect unknown
Transcript: ENSMUST00000166022
AA Change: S7P
SMART Domains Protein: ENSMUSP00000131056
Gene: ENSMUSG00000022996
AA Change: S7P

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
WNT1 50 389 9.1e-128 SMART
Predicted Effect unknown
Transcript: ENSMUST00000226610
AA Change: S7P
Predicted Effect unknown
Transcript: ENSMUST00000226655
AA Change: S7P
Predicted Effect unknown
Transcript: ENSMUST00000226846
AA Change: S7P
Predicted Effect probably benign
Transcript: ENSMUST00000228546
Predicted Effect unknown
Transcript: ENSMUST00000228594
AA Change: S7P
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutant mice fed a low- or high-fat diet exhibit accelerated myogenic differentiation of myoblasts and those fed a high-fat diet exhibit excessive lipid accumulation in actively regenerating muscle. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aoc1l2 A T 6: 48,909,477 (GRCm39) Y574F probably benign Het
Apc C T 18: 34,450,723 (GRCm39) P2506S probably damaging Het
Bdp1 T A 13: 100,206,711 (GRCm39) K610N possibly damaging Het
Bri3bp T G 5: 125,531,581 (GRCm39) C176G probably damaging Het
Carnmt1 A G 19: 18,668,818 (GRCm39) I248V probably benign Het
Ccdc88b A G 19: 6,822,454 (GRCm39) L1475P probably damaging Het
Cfap100 C T 6: 90,383,103 (GRCm39) V511M possibly damaging Het
Chchd3 T C 6: 32,780,838 (GRCm39) N78S probably benign Het
Cnnm4 G A 1: 36,537,115 (GRCm39) E480K possibly damaging Het
Cyp2d34 T A 15: 82,500,978 (GRCm39) I385F possibly damaging Het
D930048N14Rik T A 11: 51,545,615 (GRCm39) probably benign Het
Dgkg A T 16: 22,419,340 (GRCm39) D53E probably benign Het
Dlx3 T A 11: 95,011,359 (GRCm39) L71H probably damaging Het
Egln2 A C 7: 26,859,717 (GRCm39) V332G probably null Het
Entpd2 A G 2: 25,288,746 (GRCm39) Q250R probably benign Het
Epyc A G 10: 97,510,593 (GRCm39) D132G probably damaging Het
Fxr2 A G 11: 69,543,114 (GRCm39) D637G probably benign Het
Gapvd1 A G 2: 34,596,708 (GRCm39) probably null Het
Gbp11 G A 5: 105,479,194 (GRCm39) probably benign Het
Gm17175 A T 14: 51,808,307 (GRCm39) C162S probably damaging Het
Gm5499 C T 17: 87,386,339 (GRCm39) noncoding transcript Het
Gps1 T C 11: 120,679,086 (GRCm39) V378A probably benign Het
Grik1 C T 16: 87,754,481 (GRCm39) R368Q probably benign Het
Gsap A G 5: 21,431,318 (GRCm39) E214G probably benign Het
H2bc13 A G 13: 21,900,064 (GRCm39) Y84H probably damaging Het
Jdp2 T C 12: 85,655,020 (GRCm39) S28P probably benign Het
Kif26b T C 1: 178,698,240 (GRCm39) F577S probably damaging Het
Kl G A 5: 150,904,130 (GRCm39) G294D probably damaging Het
Lgsn T A 1: 31,243,041 (GRCm39) D374E probably damaging Het
Lman1 T C 18: 66,124,681 (GRCm39) I353V probably damaging Het
Lmna T C 3: 88,392,270 (GRCm39) H374R probably benign Het
Lrrc57 A G 2: 120,439,286 (GRCm39) S31P probably benign Het
Lum T A 10: 97,404,547 (GRCm39) N147K probably damaging Het
Or6n2 T C 1: 173,897,632 (GRCm39) I256T probably benign Het
Or7a41 A G 10: 78,871,445 (GRCm39) T272A probably benign Het
P4ha3 C A 7: 99,955,140 (GRCm39) L332I probably damaging Het
Pelp1 A G 11: 70,286,505 (GRCm39) I541T probably damaging Het
Pja2 A C 17: 64,620,023 (GRCm39) S2A probably benign Het
Rhbdl3 T C 11: 80,244,268 (GRCm39) L325P probably damaging Het
Robo2 T C 16: 74,149,744 (GRCm39) D28G probably damaging Het
Rpa1 A G 11: 75,198,111 (GRCm39) Y470H probably damaging Het
Rtn3 T C 19: 7,434,645 (GRCm39) N430S probably benign Het
Scg2 T A 1: 79,414,538 (GRCm39) I62L probably benign Het
Scn5a T A 9: 119,391,507 (GRCm39) K62* probably null Het
Sec23ip T C 7: 128,364,129 (GRCm39) V469A probably benign Het
Shank1 A G 7: 43,991,544 (GRCm39) T663A unknown Het
Slco1a7 A T 6: 141,700,192 (GRCm39) Y113* probably null Het
Stab2 G T 10: 86,737,567 (GRCm39) probably null Het
Tmcc3 T C 10: 94,418,147 (GRCm39) L305P probably damaging Het
Tmem145 A G 7: 25,014,260 (GRCm39) N458S probably damaging Het
Tpr G A 1: 150,302,738 (GRCm39) R1412Q probably damaging Het
Wdr1 A T 5: 38,703,058 (GRCm39) F173I possibly damaging Het
Wdr17 C T 8: 55,104,380 (GRCm39) V898I probably benign Het
Wdr64 A T 1: 175,547,899 (GRCm39) L145F probably benign Het
Zfyve26 A T 12: 79,298,957 (GRCm39) probably null Het
Other mutations in Wnt10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0555:Wnt10b UTSW 15 98,670,818 (GRCm39) splice site probably benign
R1747:Wnt10b UTSW 15 98,672,214 (GRCm39) missense probably benign 0.00
R1751:Wnt10b UTSW 15 98,670,556 (GRCm39) missense probably damaging 0.99
R1767:Wnt10b UTSW 15 98,670,556 (GRCm39) missense probably damaging 0.99
R2272:Wnt10b UTSW 15 98,672,228 (GRCm39) missense probably damaging 0.99
R2282:Wnt10b UTSW 15 98,672,102 (GRCm39) missense probably damaging 0.99
R3911:Wnt10b UTSW 15 98,672,219 (GRCm39) missense possibly damaging 0.53
R4997:Wnt10b UTSW 15 98,672,084 (GRCm39) missense probably damaging 0.99
R5226:Wnt10b UTSW 15 98,674,495 (GRCm39) missense probably damaging 1.00
R7514:Wnt10b UTSW 15 98,672,045 (GRCm39) missense probably benign 0.28
R8516:Wnt10b UTSW 15 98,670,761 (GRCm39) missense probably damaging 0.99
R9551:Wnt10b UTSW 15 98,670,713 (GRCm39) missense probably damaging 1.00
R9552:Wnt10b UTSW 15 98,670,713 (GRCm39) missense probably damaging 1.00
R9617:Wnt10b UTSW 15 98,674,609 (GRCm39) missense probably damaging 0.99
Posted On 2013-10-07