Incidental Mutation 'IGL01348:Tpx2'
ID |
75143 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Tpx2
|
Ensembl Gene |
ENSMUSG00000027469 |
Gene Name |
TPX2, microtubule-associated |
Synonyms |
2610005B21Rik, p100, DIL2, REPP86 |
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
IGL01348
|
Quality Score |
|
Status
|
|
Chromosome |
2 |
Chromosomal Location |
152689884-152737241 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 152735511 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Lysine to Arginine
at position 713
(K713R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000136457
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028969]
[ENSMUST00000109816]
[ENSMUST00000164120]
[ENSMUST00000178997]
|
AlphaFold |
A2APB8 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000028969
AA Change: K713R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000028969 Gene: ENSMUSG00000027469 AA Change: K713R
Domain | Start | End | E-Value | Type |
Pfam:Aurora-A_bind
|
1 |
68 |
7.4e-39 |
PFAM |
coiled coil region
|
213 |
242 |
N/A |
INTRINSIC |
Pfam:TPX2_importin
|
360 |
541 |
1e-62 |
PFAM |
low complexity region
|
608 |
619 |
N/A |
INTRINSIC |
Pfam:TPX2
|
661 |
717 |
6.3e-19 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000109816
AA Change: K713R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000105441 Gene: ENSMUSG00000027469 AA Change: K713R
Domain | Start | End | E-Value | Type |
Pfam:Aurora-A_bind
|
1 |
68 |
7.4e-39 |
PFAM |
coiled coil region
|
213 |
242 |
N/A |
INTRINSIC |
Pfam:TPX2_importin
|
360 |
541 |
1e-62 |
PFAM |
low complexity region
|
608 |
619 |
N/A |
INTRINSIC |
Pfam:TPX2
|
661 |
717 |
6.3e-19 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000164120
AA Change: K713R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000128888 Gene: ENSMUSG00000027469 AA Change: K713R
Domain | Start | End | E-Value | Type |
Pfam:Aurora-A_bind
|
1 |
68 |
5.2e-40 |
PFAM |
coiled coil region
|
213 |
242 |
N/A |
INTRINSIC |
Pfam:TPX2_importin
|
362 |
489 |
2.7e-35 |
PFAM |
low complexity region
|
608 |
619 |
N/A |
INTRINSIC |
Pfam:TPX2
|
661 |
717 |
7.5e-15 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000178997
AA Change: K713R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000136457 Gene: ENSMUSG00000027469 AA Change: K713R
Domain | Start | End | E-Value | Type |
Pfam:Aurora-A_bind
|
1 |
68 |
5.2e-40 |
PFAM |
coiled coil region
|
213 |
242 |
N/A |
INTRINSIC |
Pfam:TPX2_importin
|
362 |
489 |
2.7e-35 |
PFAM |
low complexity region
|
608 |
619 |
N/A |
INTRINSIC |
Pfam:TPX2
|
661 |
717 |
7.5e-15 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a gene trap allele exhibit embryonic arrest at the morula stage, embryonic lethality and tetraploidy of cultured E1.5 embryos. Mice heterozygous for the gene trap allele exhibit aneuploidy and increased tumor incidence. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 64 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700093K21Rik |
T |
C |
11: 23,467,213 (GRCm39) |
E140G |
probably null |
Het |
Adgrl3 |
A |
G |
5: 81,874,570 (GRCm39) |
T956A |
probably damaging |
Het |
Aff4 |
G |
A |
11: 53,293,327 (GRCm39) |
S772N |
probably benign |
Het |
Ark2n |
A |
G |
18: 77,761,613 (GRCm39) |
I233T |
possibly damaging |
Het |
Atad5 |
A |
G |
11: 79,986,390 (GRCm39) |
I492M |
probably benign |
Het |
Atf4 |
T |
C |
15: 80,140,728 (GRCm39) |
|
probably benign |
Het |
Atrip |
A |
G |
9: 108,898,363 (GRCm39) |
S219P |
probably damaging |
Het |
Axl |
G |
A |
7: 25,462,734 (GRCm39) |
R656W |
probably damaging |
Het |
B3gnt3 |
T |
A |
8: 72,145,648 (GRCm39) |
Q240L |
possibly damaging |
Het |
Baz2b |
A |
G |
2: 59,764,031 (GRCm39) |
V915A |
possibly damaging |
Het |
Cacna1s |
T |
C |
1: 136,002,890 (GRCm39) |
V329A |
possibly damaging |
Het |
Celf3 |
C |
A |
3: 94,395,535 (GRCm39) |
Q388K |
possibly damaging |
Het |
Ciita |
T |
C |
16: 10,328,591 (GRCm39) |
S292P |
probably damaging |
Het |
Cip2a |
A |
G |
16: 48,833,551 (GRCm39) |
I551V |
probably damaging |
Het |
Clec18a |
G |
A |
8: 111,798,245 (GRCm39) |
A423V |
probably damaging |
Het |
Clnk |
T |
C |
5: 38,870,550 (GRCm39) |
D336G |
probably damaging |
Het |
Csmd1 |
T |
G |
8: 15,960,596 (GRCm39) |
H3273P |
probably damaging |
Het |
Cyp3a11 |
A |
T |
5: 145,805,817 (GRCm39) |
V157E |
possibly damaging |
Het |
Dcp1b |
T |
C |
6: 119,160,679 (GRCm39) |
I87T |
probably damaging |
Het |
Ell3 |
A |
G |
2: 121,272,277 (GRCm39) |
S66P |
probably damaging |
Het |
Ercc4 |
T |
C |
16: 12,950,798 (GRCm39) |
F631L |
probably damaging |
Het |
Etl4 |
T |
A |
2: 20,811,784 (GRCm39) |
V1289D |
probably damaging |
Het |
Gm16372 |
T |
C |
12: 24,543,606 (GRCm39) |
|
probably benign |
Het |
Gm4553 |
C |
T |
7: 141,718,909 (GRCm39) |
C173Y |
unknown |
Het |
Gvin-ps5 |
T |
A |
7: 105,929,042 (GRCm39) |
H285L |
unknown |
Het |
Gykl1 |
A |
T |
18: 52,827,808 (GRCm39) |
I339F |
possibly damaging |
Het |
H60b |
A |
C |
10: 22,162,078 (GRCm39) |
N101T |
possibly damaging |
Het |
Inpp4a |
C |
T |
1: 37,427,986 (GRCm39) |
T407I |
probably damaging |
Het |
Itga11 |
A |
G |
9: 62,651,861 (GRCm39) |
N331S |
possibly damaging |
Het |
Kbtbd6 |
T |
A |
14: 79,690,783 (GRCm39) |
C430S |
probably damaging |
Het |
Mfsd4a |
T |
C |
1: 131,995,564 (GRCm39) |
S1G |
probably null |
Het |
Mybpc2 |
C |
A |
7: 44,165,352 (GRCm39) |
M372I |
probably benign |
Het |
Myh10 |
A |
T |
11: 68,702,629 (GRCm39) |
T1768S |
probably benign |
Het |
Myh8 |
A |
G |
11: 67,188,606 (GRCm39) |
K1063E |
probably damaging |
Het |
Nat8f5 |
A |
T |
6: 85,794,862 (GRCm39) |
F33I |
probably damaging |
Het |
Nbeal2 |
T |
G |
9: 110,458,214 (GRCm39) |
N2119T |
probably damaging |
Het |
Nek11 |
C |
T |
9: 105,270,112 (GRCm39) |
G37S |
probably damaging |
Het |
Npc1l1 |
T |
C |
11: 6,177,974 (GRCm39) |
N479D |
probably damaging |
Het |
Nup160 |
A |
G |
2: 90,530,772 (GRCm39) |
T477A |
probably benign |
Het |
Or10al5 |
A |
T |
17: 38,063,177 (GRCm39) |
H144L |
probably benign |
Het |
Or5h18 |
T |
A |
16: 58,848,157 (GRCm39) |
T38S |
probably damaging |
Het |
Pcgf2 |
A |
G |
11: 97,581,066 (GRCm39) |
V259A |
probably benign |
Het |
Pmm1 |
A |
G |
15: 81,836,219 (GRCm39) |
V131A |
probably damaging |
Het |
Polr3a |
A |
T |
14: 24,511,831 (GRCm39) |
D908E |
probably damaging |
Het |
Psg29 |
A |
C |
7: 16,944,598 (GRCm39) |
R369S |
probably benign |
Het |
Ptprq |
T |
A |
10: 107,547,765 (GRCm39) |
D211V |
probably damaging |
Het |
Rdh9 |
A |
G |
10: 127,612,661 (GRCm39) |
N103S |
probably benign |
Het |
Riok3 |
T |
C |
18: 12,286,020 (GRCm39) |
|
probably benign |
Het |
Serpinb1b |
A |
T |
13: 33,275,398 (GRCm39) |
Q174H |
probably benign |
Het |
Sgip1 |
G |
T |
4: 102,772,353 (GRCm39) |
|
probably null |
Het |
Sgpp1 |
A |
T |
12: 75,781,767 (GRCm39) |
Y191N |
probably damaging |
Het |
Slc12a1 |
A |
G |
2: 125,036,051 (GRCm39) |
N641S |
probably damaging |
Het |
Slc5a4b |
T |
C |
10: 75,906,422 (GRCm39) |
N399S |
probably damaging |
Het |
Snx16 |
C |
T |
3: 10,484,219 (GRCm39) |
A335T |
probably damaging |
Het |
Sos2 |
C |
T |
12: 69,664,866 (GRCm39) |
R355H |
probably damaging |
Het |
Szt2 |
A |
G |
4: 118,250,821 (GRCm39) |
|
probably benign |
Het |
Tbcd |
T |
A |
11: 121,387,902 (GRCm39) |
D344E |
probably benign |
Het |
Tek |
C |
A |
4: 94,747,895 (GRCm39) |
Q988K |
probably damaging |
Het |
Tgm6 |
A |
G |
2: 129,979,299 (GRCm39) |
D143G |
probably damaging |
Het |
Trappc9 |
T |
A |
15: 72,808,858 (GRCm39) |
E556V |
possibly damaging |
Het |
Trpm6 |
A |
T |
19: 18,855,015 (GRCm39) |
K1891N |
probably damaging |
Het |
Trpv1 |
G |
A |
11: 73,129,078 (GRCm39) |
|
probably null |
Het |
Usp37 |
T |
C |
1: 74,500,861 (GRCm39) |
S567G |
probably damaging |
Het |
Zfp773 |
A |
T |
7: 7,138,314 (GRCm39) |
V107D |
possibly damaging |
Het |
|
Other mutations in Tpx2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01810:Tpx2
|
APN |
2 |
152,726,155 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01951:Tpx2
|
APN |
2 |
152,726,096 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02184:Tpx2
|
APN |
2 |
152,724,240 (GRCm39) |
nonsense |
probably null |
|
IGL02422:Tpx2
|
APN |
2 |
152,715,064 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02441:Tpx2
|
APN |
2 |
152,724,207 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7952_Tpx2_601
|
UTSW |
2 |
152,735,514 (GRCm39) |
missense |
probably damaging |
1.00 |
reddened
|
UTSW |
2 |
152,711,644 (GRCm39) |
missense |
probably benign |
0.00 |
Shamed
|
UTSW |
2 |
152,715,024 (GRCm39) |
missense |
probably benign |
|
R0063:Tpx2
|
UTSW |
2 |
152,722,043 (GRCm39) |
missense |
probably damaging |
0.99 |
R0076:Tpx2
|
UTSW |
2 |
152,735,603 (GRCm39) |
missense |
probably damaging |
1.00 |
R0271:Tpx2
|
UTSW |
2 |
152,709,287 (GRCm39) |
splice site |
probably benign |
|
R0311:Tpx2
|
UTSW |
2 |
152,732,412 (GRCm39) |
missense |
probably damaging |
0.98 |
R0617:Tpx2
|
UTSW |
2 |
152,715,058 (GRCm39) |
missense |
probably benign |
0.01 |
R1871:Tpx2
|
UTSW |
2 |
152,735,523 (GRCm39) |
missense |
probably damaging |
1.00 |
R1882:Tpx2
|
UTSW |
2 |
152,711,611 (GRCm39) |
missense |
probably benign |
|
R1990:Tpx2
|
UTSW |
2 |
152,732,544 (GRCm39) |
missense |
probably benign |
|
R1991:Tpx2
|
UTSW |
2 |
152,732,544 (GRCm39) |
missense |
probably benign |
|
R1992:Tpx2
|
UTSW |
2 |
152,732,544 (GRCm39) |
missense |
probably benign |
|
R4686:Tpx2
|
UTSW |
2 |
152,731,103 (GRCm39) |
missense |
possibly damaging |
0.62 |
R4712:Tpx2
|
UTSW |
2 |
152,726,958 (GRCm39) |
missense |
probably damaging |
1.00 |
R4792:Tpx2
|
UTSW |
2 |
152,727,016 (GRCm39) |
missense |
probably damaging |
0.98 |
R4873:Tpx2
|
UTSW |
2 |
152,735,535 (GRCm39) |
missense |
probably benign |
0.00 |
R4875:Tpx2
|
UTSW |
2 |
152,735,535 (GRCm39) |
missense |
probably benign |
0.00 |
R4991:Tpx2
|
UTSW |
2 |
152,711,644 (GRCm39) |
missense |
probably benign |
0.00 |
R5178:Tpx2
|
UTSW |
2 |
152,717,469 (GRCm39) |
missense |
probably benign |
0.01 |
R5757:Tpx2
|
UTSW |
2 |
152,727,151 (GRCm39) |
splice site |
probably null |
|
R6158:Tpx2
|
UTSW |
2 |
152,715,024 (GRCm39) |
missense |
probably benign |
|
R6225:Tpx2
|
UTSW |
2 |
152,718,548 (GRCm39) |
missense |
probably benign |
|
R6539:Tpx2
|
UTSW |
2 |
152,718,518 (GRCm39) |
nonsense |
probably null |
|
R6633:Tpx2
|
UTSW |
2 |
152,709,274 (GRCm39) |
missense |
probably damaging |
1.00 |
R7358:Tpx2
|
UTSW |
2 |
152,718,550 (GRCm39) |
missense |
probably benign |
|
R7741:Tpx2
|
UTSW |
2 |
152,709,263 (GRCm39) |
missense |
possibly damaging |
0.84 |
R7952:Tpx2
|
UTSW |
2 |
152,735,514 (GRCm39) |
missense |
probably damaging |
1.00 |
R8433:Tpx2
|
UTSW |
2 |
152,722,056 (GRCm39) |
missense |
probably damaging |
0.99 |
R8888:Tpx2
|
UTSW |
2 |
152,724,255 (GRCm39) |
missense |
probably damaging |
1.00 |
R8895:Tpx2
|
UTSW |
2 |
152,724,255 (GRCm39) |
missense |
probably damaging |
1.00 |
R8920:Tpx2
|
UTSW |
2 |
152,726,214 (GRCm39) |
missense |
probably damaging |
0.99 |
R9191:Tpx2
|
UTSW |
2 |
152,727,124 (GRCm39) |
missense |
possibly damaging |
0.91 |
R9267:Tpx2
|
UTSW |
2 |
152,732,517 (GRCm39) |
missense |
probably damaging |
0.99 |
R9486:Tpx2
|
UTSW |
2 |
152,726,933 (GRCm39) |
missense |
probably damaging |
1.00 |
R9610:Tpx2
|
UTSW |
2 |
152,715,124 (GRCm39) |
missense |
probably benign |
0.05 |
R9611:Tpx2
|
UTSW |
2 |
152,715,124 (GRCm39) |
missense |
probably benign |
0.05 |
R9679:Tpx2
|
UTSW |
2 |
152,711,618 (GRCm39) |
missense |
possibly damaging |
0.87 |
R9722:Tpx2
|
UTSW |
2 |
152,733,476 (GRCm39) |
critical splice donor site |
probably null |
|
X0023:Tpx2
|
UTSW |
2 |
152,726,948 (GRCm39) |
missense |
probably benign |
0.05 |
|
Posted On |
2013-10-07 |