Incidental Mutation 'IGL01300:Or1j10'
ID 75220
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1j10
Ensembl Gene ENSMUSG00000068950
Gene Name olfactory receptor family 1 subfamily J member 10
Synonyms GA_x6K02T2NLDC-33070879-33071799, Olfr338, MOR136-5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # IGL01300
Quality Score
Status
Chromosome 2
Chromosomal Location 36266790-36267710 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 36267054 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 89 (S89P)
Ref Sequence ENSEMBL: ENSMUSP00000149146 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072114] [ENSMUST00000091006] [ENSMUST00000217511]
AlphaFold Q8VGK6
Predicted Effect probably benign
Transcript: ENSMUST00000072114
AA Change: S89P

PolyPhen 2 Score 0.132 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000071985
Gene: ENSMUSG00000068950
AA Change: S89P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.3e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.8e-8 PFAM
Pfam:7tm_1 41 290 1.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000091006
AA Change: S89P

PolyPhen 2 Score 0.132 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000088528
Gene: ENSMUSG00000068950
AA Change: S89P

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 3.9e-56 PFAM
Pfam:7tm_1 39 288 4.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217511
AA Change: S89P

PolyPhen 2 Score 0.132 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anxa8 A G 14: 33,821,700 (GRCm39) D300G probably benign Het
Cacna1g T C 11: 94,324,738 (GRCm39) H1161R probably benign Het
Col14a1 G A 15: 55,331,372 (GRCm39) R1471Q unknown Het
Gm14496 A T 2: 181,642,753 (GRCm39) E808V probably damaging Het
Gm1968 T C 16: 29,781,038 (GRCm39) noncoding transcript Het
Gzmb G A 14: 56,497,653 (GRCm39) R196C probably benign Het
Hkdc1 A G 10: 62,231,040 (GRCm39) probably benign Het
Itgal T A 7: 126,913,290 (GRCm39) V629E probably damaging Het
Jak2 T A 19: 29,287,083 (GRCm39) Y1050N probably damaging Het
Lrrc69 C T 4: 14,773,663 (GRCm39) probably benign Het
Mmd T C 11: 90,140,537 (GRCm39) M1T probably null Het
Myh6 A G 14: 55,200,548 (GRCm39) V191A possibly damaging Het
Mynn A G 3: 30,667,755 (GRCm39) N485S probably damaging Het
Naa30 C T 14: 49,410,714 (GRCm39) T214M probably damaging Het
Ncoa3 A T 2: 165,910,381 (GRCm39) T1265S probably benign Het
Or10al2 C A 17: 37,983,778 (GRCm39) T288K probably damaging Het
Prex1 A G 2: 166,480,327 (GRCm39) C138R possibly damaging Het
Prom2 A T 2: 127,377,009 (GRCm39) L535H probably benign Het
Pros1 T C 16: 62,734,174 (GRCm39) F327L possibly damaging Het
Ros1 A G 10: 51,977,809 (GRCm39) M1479T probably benign Het
Scn9a G A 2: 66,318,397 (GRCm39) Q1465* probably null Het
Serpinb3b A G 1: 107,083,573 (GRCm39) probably benign Het
Sipa1l3 G A 7: 29,099,253 (GRCm39) Q339* probably null Het
Slc34a2 A C 5: 53,225,469 (GRCm39) probably null Het
Smc3 T A 19: 53,630,283 (GRCm39) probably benign Het
Tmem30a A G 9: 79,682,382 (GRCm39) probably null Het
Trappc11 A T 8: 47,954,903 (GRCm39) D878E probably benign Het
Trrap C T 5: 144,741,628 (GRCm39) T1325M probably damaging Het
Ttc12 A T 9: 49,359,222 (GRCm39) probably benign Het
Vmn1r237 T A 17: 21,534,337 (GRCm39) I20N probably damaging Het
Vmn2r115 T A 17: 23,578,755 (GRCm39) S743T probably damaging Het
Vmn2r74 A G 7: 85,606,414 (GRCm39) Y311H probably benign Het
Vnn3 T A 10: 23,740,263 (GRCm39) F189I possibly damaging Het
Other mutations in Or1j10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Or1j10 APN 2 36,266,928 (GRCm39) missense probably damaging 0.99
IGL01089:Or1j10 APN 2 36,267,178 (GRCm39) missense probably damaging 1.00
IGL01298:Or1j10 APN 2 36,267,460 (GRCm39) missense probably benign 0.01
IGL01632:Or1j10 APN 2 36,267,576 (GRCm39) missense probably benign 0.02
IGL02480:Or1j10 APN 2 36,267,504 (GRCm39) missense probably damaging 0.98
IGL02519:Or1j10 APN 2 36,267,325 (GRCm39) missense possibly damaging 0.84
IGL02658:Or1j10 APN 2 36,267,072 (GRCm39) missense probably damaging 0.97
IGL02716:Or1j10 APN 2 36,267,355 (GRCm39) missense possibly damaging 0.88
IGL02983:Or1j10 APN 2 36,267,649 (GRCm39) missense probably damaging 1.00
IGL03334:Or1j10 APN 2 36,267,063 (GRCm39) missense possibly damaging 0.66
IGL03054:Or1j10 UTSW 2 36,266,944 (GRCm39) missense possibly damaging 0.65
R0469:Or1j10 UTSW 2 36,267,474 (GRCm39) missense probably benign 0.02
R1263:Or1j10 UTSW 2 36,267,006 (GRCm39) missense probably damaging 0.99
R1500:Or1j10 UTSW 2 36,267,633 (GRCm39) missense probably benign 0.04
R2444:Or1j10 UTSW 2 36,267,625 (GRCm39) missense possibly damaging 0.59
R5571:Or1j10 UTSW 2 36,267,129 (GRCm39) missense probably benign 0.01
R5999:Or1j10 UTSW 2 36,267,322 (GRCm39) missense probably damaging 1.00
R6030:Or1j10 UTSW 2 36,267,556 (GRCm39) missense probably damaging 0.97
R6030:Or1j10 UTSW 2 36,267,556 (GRCm39) missense probably damaging 0.97
R6351:Or1j10 UTSW 2 36,267,208 (GRCm39) missense possibly damaging 0.78
R6695:Or1j10 UTSW 2 36,267,117 (GRCm39) missense probably benign 0.28
R6785:Or1j10 UTSW 2 36,266,963 (GRCm39) nonsense probably null
R6785:Or1j10 UTSW 2 36,266,854 (GRCm39) missense probably benign 0.12
R7795:Or1j10 UTSW 2 36,267,453 (GRCm39) missense probably benign 0.05
R7814:Or1j10 UTSW 2 36,266,821 (GRCm39) missense possibly damaging 0.48
R7878:Or1j10 UTSW 2 36,267,145 (GRCm39) missense probably damaging 1.00
R8820:Or1j10 UTSW 2 36,267,006 (GRCm39) missense probably damaging 1.00
R8952:Or1j10 UTSW 2 36,267,402 (GRCm39) missense probably benign 0.01
R9512:Or1j10 UTSW 2 36,267,325 (GRCm39) missense possibly damaging 0.84
R9676:Or1j10 UTSW 2 36,266,848 (GRCm39) missense probably benign 0.01
R9705:Or1j10 UTSW 2 36,266,962 (GRCm39) missense probably damaging 0.98
Posted On 2013-10-07