Incidental Mutation 'IGL01349:Or2y1b'
ID 75254
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2y1b
Ensembl Gene ENSMUSG00000100923
Gene Name olfactory receptor family 2 subfamily Y member 1B
Synonyms L45, MOR256-55, Olfr10, GA_x6K02T2QP88-6117098-6116163
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # IGL01349
Quality Score
Status
Chromosome 11
Chromosomal Location 49208375-49209310 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 49209127 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 251 (Y251*)
Gene Model predicted gene model for transcript(s): [ENSMUST00000187570] [ENSMUST00000215671] [ENSMUST00000217290]
AlphaFold Q60883
Predicted Effect probably null
Transcript: ENSMUST00000074358
AA Change: Y251*
SMART Domains Protein: ENSMUSP00000073963
Gene: ENSMUSG00000057168
AA Change: Y251*

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 9.5e-49 PFAM
Pfam:7TM_GPCR_Srsx 35 222 4.7e-7 PFAM
Pfam:7tm_1 41 289 6.9e-24 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000187570
AA Change: Y251*
SMART Domains Protein: ENSMUSP00000139744
Gene: ENSMUSG00000100923
AA Change: Y251*

DomainStartEndE-ValueType
low complexity region 23 34 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 35 222 4.7e-7 PFAM
Pfam:7tm_1 41 289 1.3e-33 PFAM
Pfam:7tm_4 139 282 4.6e-43 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215671
Predicted Effect probably null
Transcript: ENSMUST00000217290
AA Change: Y251*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 C T 11: 9,242,076 (GRCm39) S1313L probably benign Het
Adam28 T C 14: 68,848,455 (GRCm39) H667R probably benign Het
Arap1 T C 7: 101,036,359 (GRCm39) V382A possibly damaging Het
Arih2 T C 9: 108,482,609 (GRCm39) Y444C probably damaging Het
Asxl3 T G 18: 22,657,294 (GRCm39) V1768G probably benign Het
Bbs9 T A 9: 22,798,979 (GRCm39) M869K probably benign Het
C4bp A G 1: 130,570,665 (GRCm39) probably benign Het
Cc2d2a A T 5: 43,881,126 (GRCm39) Y1167F probably benign Het
Cgn T A 3: 94,674,486 (GRCm39) K884* probably null Het
Chd1l T C 3: 97,498,550 (GRCm39) Y283C probably benign Het
Cry1 A G 10: 84,984,603 (GRCm39) V157A probably benign Het
Dcc T A 18: 71,503,808 (GRCm39) D950V probably damaging Het
Dlc1 A G 8: 37,050,978 (GRCm39) F918L probably damaging Het
Dnah2 T C 11: 69,366,432 (GRCm39) N1890S probably damaging Het
Dnah5 A G 15: 28,295,059 (GRCm39) probably benign Het
Eif4b C T 15: 101,999,858 (GRCm39) T412I probably benign Het
Eloa A C 4: 135,741,758 (GRCm39) Y29D probably benign Het
Erbb4 A G 1: 68,385,752 (GRCm39) F279S probably benign Het
Etl4 A G 2: 20,718,207 (GRCm39) D316G probably damaging Het
Gm5114 T C 7: 39,058,531 (GRCm39) S363G probably benign Het
Gpam A G 19: 55,084,551 (GRCm39) probably null Het
Il17rd T A 14: 26,817,901 (GRCm39) S197T probably damaging Het
Iqsec3 T C 6: 121,450,083 (GRCm39) E147G possibly damaging Het
Itk T A 11: 46,232,027 (GRCm39) T303S possibly damaging Het
Kcnh6 A G 11: 105,914,743 (GRCm39) D716G possibly damaging Het
Lca5 A G 9: 83,308,670 (GRCm39) S59P probably damaging Het
Lrrc40 T C 3: 157,764,302 (GRCm39) probably benign Het
Mmp7 T C 9: 7,699,335 (GRCm39) probably benign Het
Mycbp2 T C 14: 103,359,983 (GRCm39) T4427A probably damaging Het
Nf2 T C 11: 4,734,472 (GRCm39) D513G possibly damaging Het
Pde7a C T 3: 19,283,843 (GRCm39) probably benign Het
Pira2 T C 7: 3,847,138 (GRCm39) T135A probably damaging Het
Rb1 T C 14: 73,506,558 (GRCm39) Y397C probably damaging Het
Ros1 A T 10: 51,927,122 (GRCm39) M2187K probably damaging Het
Ryr2 T A 13: 11,602,125 (GRCm39) I4586F possibly damaging Het
Serpinb3c A T 1: 107,200,513 (GRCm39) M210K probably damaging Het
Slc22a19 C A 19: 7,651,792 (GRCm39) V472F probably benign Het
Slc4a11 A G 2: 130,528,863 (GRCm39) I462T probably benign Het
Spag11b A T 8: 19,191,492 (GRCm39) H55L probably damaging Het
Trpv5 G T 6: 41,652,309 (GRCm39) N125K possibly damaging Het
Ubr4 G T 4: 139,208,039 (GRCm39) R4940L unknown Het
Vcan T A 13: 89,852,062 (GRCm39) H966L probably damaging Het
Vmn1r204 T A 13: 22,740,504 (GRCm39) I45K probably damaging Het
Vnn3 A T 10: 23,727,814 (GRCm39) I75F probably damaging Het
Vps13b A T 15: 35,794,091 (GRCm39) M2256L probably benign Het
Zfc3h1 T A 10: 115,259,353 (GRCm39) L1642M probably damaging Het
Other mutations in Or2y1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02283:Or2y1b APN 11 49,209,162 (GRCm39) missense probably benign
IGL03010:Or2y1b APN 11 49,208,973 (GRCm39) missense probably damaging 0.99
R0575:Or2y1b UTSW 11 49,208,880 (GRCm39) missense probably damaging 1.00
R1430:Or2y1b UTSW 11 49,208,928 (GRCm39) splice site probably null
R1891:Or2y1b UTSW 11 49,208,684 (GRCm39) missense probably benign 0.00
R2509:Or2y1b UTSW 11 49,209,048 (GRCm39) missense probably damaging 0.97
R2511:Or2y1b UTSW 11 49,209,048 (GRCm39) missense probably damaging 0.97
R4942:Or2y1b UTSW 11 49,208,375 (GRCm39) start codon destroyed probably null 0.99
R5080:Or2y1b UTSW 11 49,208,914 (GRCm39) missense probably benign 0.03
R5413:Or2y1b UTSW 11 49,209,240 (GRCm39) missense probably damaging 1.00
R5843:Or2y1b UTSW 11 49,209,076 (GRCm39) missense probably benign 0.34
R6354:Or2y1b UTSW 11 49,208,465 (GRCm39) missense probably damaging 0.98
R6605:Or2y1b UTSW 11 49,208,541 (GRCm39) missense probably damaging 0.97
R8005:Or2y1b UTSW 11 49,208,968 (GRCm39) missense probably benign 0.12
R8284:Or2y1b UTSW 11 49,209,002 (GRCm39) missense probably benign
R8902:Or2y1b UTSW 11 49,209,206 (GRCm39) missense probably benign 0.03
R9003:Or2y1b UTSW 11 49,209,155 (GRCm39) missense possibly damaging 0.66
R9431:Or2y1b UTSW 11 49,208,459 (GRCm39) missense probably benign
R9696:Or2y1b UTSW 11 49,208,390 (GRCm39) missense probably benign
Posted On 2013-10-07