Incidental Mutation 'IGL01352:Tars3'
| ID |
75408 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tars3
|
| Ensembl Gene |
ENSMUSG00000030515 |
| Gene Name |
threonyl-tRNA synthetase 3 |
| Synonyms |
A530046H20Rik, Tarsl2 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.178)
|
| Stock # |
IGL01352
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
65294646-65341839 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 65308658 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 276
(I276T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032728
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032728]
|
| AlphaFold |
Q8BLY2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000032728
AA Change: I276T
PolyPhen 2
Score 0.802 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000032728
Gene: ENSMUSG00000030515
AA Change: I276T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
18 |
N/A |
INTRINSIC |
|
coiled coil region
|
44 |
68 |
N/A |
INTRINSIC |
|
Pfam:TGS
|
151 |
210 |
8.8e-14 |
PFAM |
|
tRNA_SAD
|
316 |
365 |
1.26e-16 |
SMART |
|
Pfam:tRNA-synt_2b
|
464 |
675 |
2.2e-35 |
PFAM |
|
Pfam:HGTP_anticodon
|
687 |
778 |
1.1e-20 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126941
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206323
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts9 |
T |
C |
6: 92,837,155 (GRCm39) |
I1169V |
probably benign |
Het |
| B3gnt5 |
T |
C |
16: 19,587,963 (GRCm39) |
S61P |
probably damaging |
Het |
| Bambi |
G |
A |
18: 3,512,071 (GRCm39) |
A152T |
probably damaging |
Het |
| Cacna1c |
G |
A |
6: 118,633,518 (GRCm39) |
Q930* |
probably null |
Het |
| Ccdc178 |
A |
G |
18: 22,152,031 (GRCm39) |
|
probably benign |
Het |
| Chit1 |
C |
T |
1: 134,076,228 (GRCm39) |
T295M |
probably damaging |
Het |
| Cntnap5c |
C |
A |
17: 58,600,896 (GRCm39) |
N746K |
probably benign |
Het |
| Cyfip2 |
A |
T |
11: 46,156,823 (GRCm39) |
F422I |
probably benign |
Het |
| Dsg3 |
A |
G |
18: 20,656,753 (GRCm39) |
M208V |
probably benign |
Het |
| Erich6 |
G |
A |
3: 58,529,781 (GRCm39) |
|
probably null |
Het |
| Gbf1 |
A |
G |
19: 46,253,654 (GRCm39) |
H574R |
probably damaging |
Het |
| Gm17654 |
T |
G |
14: 43,813,331 (GRCm39) |
E186D |
probably damaging |
Het |
| Gm8165 |
T |
C |
14: 43,913,573 (GRCm39) |
N97S |
unknown |
Het |
| Ilf3 |
C |
T |
9: 21,303,618 (GRCm39) |
L160F |
possibly damaging |
Het |
| Krt84 |
T |
A |
15: 101,437,209 (GRCm39) |
Q318L |
probably damaging |
Het |
| Lrp2 |
T |
A |
2: 69,333,870 (GRCm39) |
H1457L |
possibly damaging |
Het |
| Lrrc37a |
T |
A |
11: 103,390,181 (GRCm39) |
D1748V |
probably benign |
Het |
| Mybl1 |
T |
C |
1: 9,741,904 (GRCm39) |
E676G |
probably damaging |
Het |
| Myo10 |
C |
A |
15: 25,701,783 (GRCm39) |
R53S |
probably damaging |
Het |
| Myorg |
T |
A |
4: 41,499,469 (GRCm39) |
R54* |
probably null |
Het |
| Nrap |
A |
G |
19: 56,368,268 (GRCm39) |
S205P |
probably benign |
Het |
| Or4c52 |
A |
G |
2: 89,846,063 (GRCm39) |
D263G |
probably damaging |
Het |
| Or52z1 |
A |
T |
7: 103,437,285 (GRCm39) |
Y66* |
probably null |
Het |
| Or8b1b |
A |
G |
9: 38,376,030 (GRCm39) |
N231S |
probably benign |
Het |
| Pkhd1 |
T |
A |
1: 20,619,939 (GRCm39) |
M894L |
probably benign |
Het |
| Ptpn13 |
G |
A |
5: 103,634,641 (GRCm39) |
|
probably null |
Het |
| Pycard |
T |
C |
7: 127,592,674 (GRCm39) |
D9G |
probably damaging |
Het |
| Rbfox3 |
G |
A |
11: 118,396,439 (GRCm39) |
|
probably benign |
Het |
| Rnf122 |
C |
T |
8: 31,614,908 (GRCm39) |
R71* |
probably null |
Het |
| Scel |
T |
A |
14: 103,770,774 (GRCm39) |
D69E |
possibly damaging |
Het |
| Spag6 |
T |
G |
2: 18,715,284 (GRCm39) |
M21R |
possibly damaging |
Het |
| Stat5a |
A |
G |
11: 100,771,898 (GRCm39) |
D650G |
probably damaging |
Het |
| Tnfaip2 |
G |
T |
12: 111,412,053 (GRCm39) |
E151D |
probably damaging |
Het |
| Trio |
G |
A |
15: 27,901,315 (GRCm39) |
T313I |
probably benign |
Het |
| Ubqln4 |
A |
C |
3: 88,471,775 (GRCm39) |
M404L |
probably benign |
Het |
| Vps33b |
T |
A |
7: 79,934,807 (GRCm39) |
|
probably null |
Het |
| Wdfy3 |
A |
T |
5: 102,091,986 (GRCm39) |
V451D |
probably damaging |
Het |
| Zfp341 |
G |
T |
2: 154,470,816 (GRCm39) |
A278S |
probably benign |
Het |
| Zp3r |
C |
T |
1: 130,547,093 (GRCm39) |
A28T |
possibly damaging |
Het |
|
| Other mutations in Tars3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Tars3
|
APN |
7 |
65,302,007 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL00470:Tars3
|
APN |
7 |
65,338,656 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00594:Tars3
|
APN |
7 |
65,325,880 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01519:Tars3
|
APN |
7 |
65,313,634 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01726:Tars3
|
APN |
7 |
65,332,566 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL02370:Tars3
|
APN |
7 |
65,310,913 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL02729:Tars3
|
APN |
7 |
65,332,567 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03234:Tars3
|
APN |
7 |
65,302,026 (GRCm39) |
missense |
probably benign |
0.06 |
|
gary
|
UTSW |
7 |
65,338,700 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8254_tarsl2_650
|
UTSW |
7 |
65,325,809 (GRCm39) |
missense |
probably benign |
|
|
smart_money
|
UTSW |
7 |
65,327,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0127:Tars3
|
UTSW |
7 |
65,314,717 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0153:Tars3
|
UTSW |
7 |
65,333,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0605:Tars3
|
UTSW |
7 |
65,327,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1070:Tars3
|
UTSW |
7 |
65,305,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1450:Tars3
|
UTSW |
7 |
65,297,244 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1467:Tars3
|
UTSW |
7 |
65,305,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Tars3
|
UTSW |
7 |
65,305,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2142:Tars3
|
UTSW |
7 |
65,308,645 (GRCm39) |
missense |
probably benign |
|
|
R2143:Tars3
|
UTSW |
7 |
65,305,539 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R2144:Tars3
|
UTSW |
7 |
65,305,539 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R2145:Tars3
|
UTSW |
7 |
65,305,539 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R2208:Tars3
|
UTSW |
7 |
65,332,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3713:Tars3
|
UTSW |
7 |
65,338,700 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3715:Tars3
|
UTSW |
7 |
65,338,700 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3914:Tars3
|
UTSW |
7 |
65,333,556 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3929:Tars3
|
UTSW |
7 |
65,333,791 (GRCm39) |
splice site |
probably null |
|
|
R4008:Tars3
|
UTSW |
7 |
65,327,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4064:Tars3
|
UTSW |
7 |
65,302,018 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4367:Tars3
|
UTSW |
7 |
65,332,567 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4652:Tars3
|
UTSW |
7 |
65,339,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4825:Tars3
|
UTSW |
7 |
65,297,302 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4901:Tars3
|
UTSW |
7 |
65,341,042 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4999:Tars3
|
UTSW |
7 |
65,308,683 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5423:Tars3
|
UTSW |
7 |
65,333,567 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5756:Tars3
|
UTSW |
7 |
65,325,724 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5772:Tars3
|
UTSW |
7 |
65,333,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6160:Tars3
|
UTSW |
7 |
65,332,527 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6230:Tars3
|
UTSW |
7 |
65,336,184 (GRCm39) |
splice site |
probably null |
|
|
R6424:Tars3
|
UTSW |
7 |
65,305,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6615:Tars3
|
UTSW |
7 |
65,327,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6792:Tars3
|
UTSW |
7 |
65,312,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Tars3
|
UTSW |
7 |
65,308,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7549:Tars3
|
UTSW |
7 |
65,297,341 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7592:Tars3
|
UTSW |
7 |
65,308,619 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7634:Tars3
|
UTSW |
7 |
65,325,760 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7710:Tars3
|
UTSW |
7 |
65,314,717 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7808:Tars3
|
UTSW |
7 |
65,302,009 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7875:Tars3
|
UTSW |
7 |
65,327,899 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8254:Tars3
|
UTSW |
7 |
65,325,809 (GRCm39) |
missense |
probably benign |
|
|
R8793:Tars3
|
UTSW |
7 |
65,294,673 (GRCm39) |
start gained |
probably benign |
|
|
R9162:Tars3
|
UTSW |
7 |
65,332,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9200:Tars3
|
UTSW |
7 |
65,302,013 (GRCm39) |
missense |
probably benign |
|
|
R9461:Tars3
|
UTSW |
7 |
65,339,719 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R9533:Tars3
|
UTSW |
7 |
65,333,808 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Tars3
|
UTSW |
7 |
65,302,012 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2013-10-07 |
Incidental Mutation