Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01353:Vmn1r76'

75422

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r76

Ensembl Gene

ENSMUSG00000115267

Gene Name

vomeronasal 1 receptor 76

Synonyms

V1rg4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

IGL01353

Quality Score

Status

Chromosome

Chromosomal Location

11664238-11665212 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 11664737 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Proline at position 159 (H159P)

Ref Sequence

ENSEMBL: ENSMUSP00000055518 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058772] [ENSMUST00000226300] [ENSMUST00000226947]

AlphaFold

F8VQ63

Predicted Effect

probably damaging
Transcript: ENSMUST00000058772
AA Change: H159P

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000055518
Gene: ENSMUSG00000115267
AA Change: H159P

Domain	Start	End	E-Value	Type
transmembrane domain	5	27	N/A	INTRINSIC
transmembrane domain	31	53	N/A	INTRINSIC
Pfam:V1R	54	317	5.4e-31	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000226300
AA Change: H124P

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)

Predicted Effect

probably damaging
Transcript: ENSMUST00000226947
AA Change: H124P

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc3	A	T	11: 94,242,934 (GRCm39)	V1304E	possibly damaging	Het
Acr	T	C	15: 89,453,695 (GRCm39)	L78P	probably damaging	Het
Adamts12	T	C	15: 11,292,091 (GRCm39)		probably benign	Het
Adgrb2	T	C	4: 129,906,093 (GRCm39)	S872P	probably damaging	Het
Adhfe1	T	A	1: 9,637,088 (GRCm39)	N413K	probably benign	Het
Apoh	T	A	11: 108,288,211 (GRCm39)	C110S	probably damaging	Het
Arhgap11a	A	G	2: 113,663,869 (GRCm39)	F805L	probably damaging	Het
Bin3	C	T	14: 70,372,275 (GRCm39)	L191F	possibly damaging	Het
Col3a1	A	G	1: 45,372,798 (GRCm39)		probably benign	Het
Dapp1	T	C	3: 137,667,241 (GRCm39)	K107R	probably benign	Het
Dnah5	T	C	15: 28,233,418 (GRCm39)	V259A	probably benign	Het
Dnah6	T	C	6: 73,150,439 (GRCm39)	M775V	probably benign	Het
Dnah9	A	G	11: 65,971,397 (GRCm39)	L1597P	probably damaging	Het
Elfn2	G	A	15: 78,556,618 (GRCm39)	A643V	possibly damaging	Het
Epha6	T	C	16: 60,245,258 (GRCm39)	T314A	probably damaging	Het
Fn1	C	A	1: 71,626,098 (GRCm39)	W2237L	probably damaging	Het
Foxp4	T	A	17: 48,199,078 (GRCm39)	D97V	probably damaging	Het
Kcnb2	C	A	1: 15,781,048 (GRCm39)	T640K	probably benign	Het
Lypd10	G	T	7: 24,413,662 (GRCm39)	S226I	probably damaging	Het
Miga2	G	A	2: 30,261,245 (GRCm39)		probably null	Het
Nacad	T	A	11: 6,550,530 (GRCm39)	Q887L	possibly damaging	Het
Or2m13	C	T	16: 19,226,333 (GRCm39)	M145I	probably benign	Het
Or4d1	T	C	11: 87,804,998 (GRCm39)	I245V	probably benign	Het
Or7e173	T	C	9: 19,938,343 (GRCm39)	N297S	probably damaging	Het
Or8k24	A	T	2: 86,216,365 (GRCm39)	Y132*	probably null	Het
Otub2	A	T	12: 103,370,581 (GRCm39)	M288L	probably benign	Het
Otud4	A	G	8: 80,391,650 (GRCm39)	S432G	probably benign	Het
Pcca	G	A	14: 122,820,029 (GRCm39)	V58I	probably damaging	Het
Pdpr	T	A	8: 111,847,910 (GRCm39)		probably null	Het
Pinx1	C	A	14: 64,103,564 (GRCm39)	Q48K	probably benign	Het
Pkd1l2	G	T	8: 117,784,182 (GRCm39)	S698R	probably benign	Het
Psg29	A	G	7: 16,938,938 (GRCm39)	R71G	possibly damaging	Het
Psmd3	T	A	11: 98,581,426 (GRCm39)	V271E	probably benign	Het
Smarcc1	A	G	9: 109,964,734 (GRCm39)	N97S	probably benign	Het
Sulf2	C	T	2: 165,929,015 (GRCm39)	G319S	probably damaging	Het
Tmem67	C	A	4: 12,079,895 (GRCm39)	C132F	probably damaging	Het
Ttll7	T	C	3: 146,667,474 (GRCm39)	L780P	probably damaging	Het
Vmn1r223	A	G	13: 23,433,426 (GRCm39)	T7A	unknown	Het
Vnn1	G	A	10: 23,776,738 (GRCm39)	C363Y	probably damaging	Het
Wdr64	T	G	1: 175,559,151 (GRCm39)	L305V	probably damaging	Het
Zkscan4	T	C	13: 21,668,518 (GRCm39)	L323P	probably damaging	Het
Zscan10	A	T	17: 23,828,574 (GRCm39)	H295L	probably damaging	Het

Other mutations in Vmn1r76

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01017:Vmn1r76	APN	7	11,664,309 (GRCm39)	missense	possibly damaging	0.50
IGL02105:Vmn1r76	APN	7	11,664,417 (GRCm39)	missense	possibly damaging	0.46
R0032:Vmn1r76	UTSW	7	11,665,194 (GRCm39)	missense	probably benign
R0879:Vmn1r76	UTSW	7	11,664,662 (GRCm39)	missense	probably benign	0.00
R1201:Vmn1r76	UTSW	7	11,664,252 (GRCm39)	missense	probably benign	0.38
R1966:Vmn1r76	UTSW	7	11,664,441 (GRCm39)	missense	probably damaging	1.00
R3030:Vmn1r76	UTSW	7	11,664,402 (GRCm39)	missense	probably damaging	1.00
R3915:Vmn1r76	UTSW	7	11,664,496 (GRCm39)	missense	probably benign	0.23
R4295:Vmn1r76	UTSW	7	11,665,057 (GRCm39)	missense	probably benign	0.44
R5053:Vmn1r76	UTSW	7	11,664,241 (GRCm39)	splice site	probably null
R5450:Vmn1r76	UTSW	7	11,664,611 (GRCm39)	missense	probably damaging	1.00
R5568:Vmn1r76	UTSW	7	11,665,062 (GRCm39)	missense	probably benign	0.02
R6382:Vmn1r76	UTSW	7	11,664,426 (GRCm39)	missense	probably damaging	1.00
R7137:Vmn1r76	UTSW	7	11,664,612 (GRCm39)	missense	possibly damaging	0.94
R7704:Vmn1r76	UTSW	7	11,664,344 (GRCm39)	missense	probably benign	0.25
R8018:Vmn1r76	UTSW	7	11,664,810 (GRCm39)	missense	probably damaging	0.99
R8540:Vmn1r76	UTSW	7	11,664,897 (GRCm39)	missense	probably damaging	1.00
R9321:Vmn1r76	UTSW	7	11,665,094 (GRCm39)	missense	possibly damaging	0.78
R9393:Vmn1r76	UTSW	7	11,664,765 (GRCm39)	missense	probably benign	0.00
Z1176:Vmn1r76	UTSW	7	11,664,495 (GRCm39)	missense	probably benign	0.36

Posted On

2013-10-07