Incidental Mutation 'P0015:Fam151b'
ID7548
Institutional Source Beutler Lab
Gene Symbol Fam151b
Ensembl Gene ENSMUSG00000034334
Gene Namefamily with sequence similarity 151, member B
Synonyms4930405M20Rik
MMRRC Submission 038268-MU
Accession Numbers

NCBI RefSeq: NM_001163627.1; MGI:1921192

Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #P0015 (G1)
Quality Score
Status Validated
Chromosome13
Chromosomal Location92449625-92484015 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 92467944 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000045024 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040106] [ENSMUST00000225299]
Predicted Effect probably null
Transcript: ENSMUST00000040106
SMART Domains Protein: ENSMUSP00000045024
Gene: ENSMUSG00000034334

DomainStartEndE-ValueType
Pfam:DUF2181 29 263 2.3e-102 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000225299
Meta Mutation Damage Score 0.9494 question?
Coding Region Coverage
  • 1x: 83.8%
  • 3x: 77.7%
  • 10x: 59.1%
  • 20x: 39.9%
Validation Efficiency 82% (537/655)
Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock
Total: 5 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Fam198b T C 3: 79,936,608 L14S probably damaging Het
Lrp1 A T 10: 127,566,663 I2213N probably damaging Het
Otop1 T C 5: 38,294,559 probably benign Het
Tnfsf14 T C 17: 57,190,815 Y139C probably damaging Het
Zfp143 A G 7: 110,086,111 probably null Het
Other mutations in Fam151b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00799:Fam151b APN 13 92477853 missense probably damaging 1.00
IGL02253:Fam151b APN 13 92477927 missense probably damaging 1.00
IGL03084:Fam151b APN 13 92468026 missense probably damaging 0.97
IGL03130:Fam151b APN 13 92450193 missense probably benign 0.01
R0067:Fam151b UTSW 13 92473996 missense probably benign 0.08
R0067:Fam151b UTSW 13 92473996 missense probably benign 0.08
R0348:Fam151b UTSW 13 92450181 missense probably benign 0.00
R1404:Fam151b UTSW 13 92473972 missense probably damaging 1.00
R1404:Fam151b UTSW 13 92473972 missense probably damaging 1.00
R1482:Fam151b UTSW 13 92450166 missense probably benign 0.03
R1837:Fam151b UTSW 13 92474131 intron probably benign
R1891:Fam151b UTSW 13 92450170 missense probably benign 0.00
R1957:Fam151b UTSW 13 92477902 missense probably damaging 1.00
R1957:Fam151b UTSW 13 92477903 missense probably damaging 1.00
R2175:Fam151b UTSW 13 92477918 missense probably damaging 0.99
R4583:Fam151b UTSW 13 92468109 missense probably damaging 1.00
R6762:Fam151b UTSW 13 92468050 missense possibly damaging 0.79
X0021:Fam151b UTSW 13 92450226 missense probably benign 0.06
Posted On2012-10-04