Incidental Mutation 'IGL01355:Tas2r108'
ID 75489
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r108
Ensembl Gene ENSMUSG00000037140
Gene Name taste receptor, type 2, member 108
Synonyms mGR08, T2R108, T2r8, mt2r8, T2R8
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # IGL01355
Quality Score
Chromosome 6
Chromosomal Location 40493529-40494541 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 40493751 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 54 (T54A)
Ref Sequence ENSEMBL: ENSMUSP00000044089 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038750] [ENSMUST00000064932]
AlphaFold Q9JKT3
Predicted Effect possibly damaging
Transcript: ENSMUST00000038750
AA Change: T54A

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000044089
Gene: ENSMUSG00000037140
AA Change: T54A

Pfam:TAS2R 1 297 5e-93 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000064932
SMART Domains Protein: ENSMUSP00000063743
Gene: ENSMUSG00000052850

Pfam:TAS2R 18 320 2.5e-91 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ajap1 C T 4: 153,386,481 V290I probably damaging Het
Ankrd12 A G 17: 65,970,340 probably benign Het
Anxa4 A T 6: 86,752,205 I140N probably damaging Het
Asap2 A G 12: 21,218,086 probably benign Het
Cd36 C T 5: 17,813,074 V214I possibly damaging Het
Col24a1 T C 3: 145,314,876 L336S probably benign Het
Dcc C T 18: 71,809,114 V311I probably benign Het
Gpr146 A T 5: 139,378,904 probably benign Het
Irf1 T C 11: 53,774,361 V188A probably benign Het
Limk1 G A 5: 134,657,900 probably benign Het
Mcidas T C 13: 112,999,069 F342S probably damaging Het
Mctp1 A G 13: 76,384,955 T141A probably benign Het
Mnd1 C A 3: 84,116,477 A101S probably benign Het
Nsun7 T C 5: 66,294,868 S466P probably damaging Het
Olfr1279 T A 2: 111,307,093 I296K probably benign Het
Olfr165 C T 16: 19,407,583 M145I probably benign Het
Olfr617 A G 7: 103,584,373 E117G probably damaging Het
Pik3c2g G T 6: 139,852,857 G371V probably damaging Het
Sdad1 A G 5: 92,302,679 V199A probably damaging Het
Spg11 C T 2: 122,113,156 V172I probably benign Het
Tmem121b A G 6: 120,492,466 L430P probably damaging Het
Traf3ip1 A G 1: 91,518,297 D384G probably damaging Het
Trank1 A G 9: 111,365,520 T871A possibly damaging Het
Vegfa T C 17: 46,025,421 M258V possibly damaging Het
Zbtb49 A G 5: 38,210,616 probably null Het
Other mutations in Tas2r108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01389:Tas2r108 APN 6 40493932 missense possibly damaging 0.89
IGL01603:Tas2r108 APN 6 40493786 missense possibly damaging 0.96
PIT4418001:Tas2r108 UTSW 6 40493680 missense probably damaging 0.96
R1562:Tas2r108 UTSW 6 40494066 splice site probably null
R1582:Tas2r108 UTSW 6 40493632 missense probably benign 0.45
R4544:Tas2r108 UTSW 6 40493808 missense probably benign 0.00
R5579:Tas2r108 UTSW 6 40494087 missense probably benign 0.01
R7840:Tas2r108 UTSW 6 40493856 missense possibly damaging 0.76
R9432:Tas2r108 UTSW 6 40494187 missense probably damaging 1.00
X0027:Tas2r108 UTSW 6 40493671 missense probably damaging 1.00
Posted On 2013-10-07