Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01355:Gpr146'

75506

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr146

Ensembl Gene

ENSMUSG00000044197

Gene Name

G protein-coupled receptor 146

Synonyms

PGR8

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01355

Quality Score

Status

Chromosome

Chromosomal Location

139377697-139396415 bp(+) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

A to T at 139378904 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000142949 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051293] [ENSMUST00000053120] [ENSMUST00000066052] [ENSMUST00000138631] [ENSMUST00000198474]

AlphaFold

Q99LE2

Predicted Effect

probably benign
Transcript: ENSMUST00000051293

SMART Domains

Protein: ENSMUSP00000049707
Gene: ENSMUSG00000044197

Domain	Start	End	E-Value	Type
low complexity region	21	36	N/A	INTRINSIC
Pfam:7tm_1	43	294	2e-16	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000053120
AA Change: M44L

Predicted Effect

probably benign
Transcript: ENSMUST00000066052

SMART Domains

Protein: ENSMUSP00000069230
Gene: ENSMUSG00000053553

Domain	Start	End	E-Value	Type
low complexity region	54	77	N/A	INTRINSIC
Pfam:DUF2373	103	165	3e-26	PFAM
low complexity region	184	194	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137254

Predicted Effect

probably benign
Transcript: ENSMUST00000138631

SMART Domains

Protein: ENSMUSP00000119464
Gene: ENSMUSG00000044197

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	26	80	3e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188655

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000196267

Predicted Effect

probably benign
Transcript: ENSMUST00000198474

SMART Domains

Protein: ENSMUSP00000142949
Gene: ENSMUSG00000053553

Domain	Start	End	E-Value	Type
low complexity region	54	77	N/A	INTRINSIC
Pfam:DUF2373	102	141	9e-12	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ajap1	C	T	4: 153,386,481	V290I	probably damaging	Het
Ankrd12	A	G	17: 65,970,340		probably benign	Het
Anxa4	A	T	6: 86,752,205	I140N	probably damaging	Het
Asap2	A	G	12: 21,218,086		probably benign	Het
Cd36	C	T	5: 17,813,074	V214I	possibly damaging	Het
Col24a1	T	C	3: 145,314,876	L336S	probably benign	Het
Dcc	C	T	18: 71,809,114	V311I	probably benign	Het
Irf1	T	C	11: 53,774,361	V188A	probably benign	Het
Limk1	G	A	5: 134,657,900		probably benign	Het
Mcidas	T	C	13: 112,999,069	F342S	probably damaging	Het
Mctp1	A	G	13: 76,384,955	T141A	probably benign	Het
Mnd1	C	A	3: 84,116,477	A101S	probably benign	Het
Nsun7	T	C	5: 66,294,868	S466P	probably damaging	Het
Olfr1279	T	A	2: 111,307,093	I296K	probably benign	Het
Olfr165	C	T	16: 19,407,583	M145I	probably benign	Het
Olfr617	A	G	7: 103,584,373	E117G	probably damaging	Het
Pik3c2g	G	T	6: 139,852,857	G371V	probably damaging	Het
Sdad1	A	G	5: 92,302,679	V199A	probably damaging	Het
Spg11	C	T	2: 122,113,156	V172I	probably benign	Het
Tas2r108	A	G	6: 40,493,751	T54A	possibly damaging	Het
Tmem121b	A	G	6: 120,492,466	L430P	probably damaging	Het
Traf3ip1	A	G	1: 91,518,297	D384G	probably damaging	Het
Trank1	A	G	9: 111,365,520	T871A	possibly damaging	Het
Vegfa	T	C	17: 46,025,421	M258V	possibly damaging	Het
Zbtb49	A	G	5: 38,210,616		probably null	Het

Other mutations in Gpr146

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02152:Gpr146	APN	5	139392712	missense	probably damaging	1.00
IGL02369:Gpr146	APN	5	139392688	missense	probably benign	0.00
IGL02392:Gpr146	APN	5	139392778	missense	probably damaging	0.99
IGL02828:Gpr146	APN	5	139392821	missense	probably damaging	0.97
IGL03095:Gpr146	APN	5	139392950	missense	probably benign	0.11
R0360:Gpr146	UTSW	5	139379178	intron	probably benign
R0364:Gpr146	UTSW	5	139379178	intron	probably benign
R0746:Gpr146	UTSW	5	139393222	missense	probably damaging	1.00
R1446:Gpr146	UTSW	5	139393422	missense	probably benign	0.00
R1507:Gpr146	UTSW	5	139393369	missense	probably benign
R1758:Gpr146	UTSW	5	139393382	missense	probably benign	0.34
R2032:Gpr146	UTSW	5	139379147	intron	probably benign
R6513:Gpr146	UTSW	5	139392818	missense	probably damaging	1.00
R6797:Gpr146	UTSW	5	139393040	missense	possibly damaging	0.79
R7830:Gpr146	UTSW	5	139392602	missense	probably benign	0.02
R7977:Gpr146	UTSW	5	139392685	missense	possibly damaging	0.53
R7987:Gpr146	UTSW	5	139392685	missense	possibly damaging	0.53
R8225:Gpr146	UTSW	5	139392616	missense	probably benign	0.03
R8792:Gpr146	UTSW	5	139392794	missense	probably damaging	1.00
R9354:Gpr146	UTSW	5	139392611	missense	probably benign	0.00
X0064:Gpr146	UTSW	5	139378909	intron	probably benign

Posted On

2013-10-07