Incidental Mutation 'IGL01356:Vmn1r203'
| ID |
75511 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r203
|
| Ensembl Gene |
ENSMUSG00000069289 |
| Gene Name |
vomeronasal 1 receptor 203 |
| Synonyms |
V1rh11 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
IGL01356
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
22708221-22709156 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 22708947 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 243
(S243G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154399
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000091729]
[ENSMUST00000227520]
[ENSMUST00000228889]
|
| AlphaFold |
Q8R273 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000091729
AA Change: S243G
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000089322
Gene: ENSMUSG00000069289
AA Change: S243G
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
19 |
41 |
N/A |
INTRINSIC |
|
Pfam:V1R
|
43 |
304 |
5.8e-35 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137651
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000227520
AA Change: S243G
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000228889
AA Change: S243G
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| AA474408 |
T |
C |
7: 109,660,189 (GRCm39) |
|
probably benign |
Het |
| Acsl1 |
T |
C |
8: 46,964,500 (GRCm39) |
|
probably null |
Het |
| Adck2 |
T |
C |
6: 39,560,854 (GRCm39) |
V463A |
probably benign |
Het |
| Armh3 |
C |
T |
19: 45,954,742 (GRCm39) |
C149Y |
possibly damaging |
Het |
| B4galt4 |
T |
A |
16: 38,574,506 (GRCm39) |
I224N |
probably damaging |
Het |
| Caprin1 |
T |
C |
2: 103,605,801 (GRCm39) |
T396A |
probably benign |
Het |
| Cbx3 |
T |
C |
6: 51,452,281 (GRCm39) |
V32A |
probably damaging |
Het |
| Chd1 |
A |
T |
17: 15,970,127 (GRCm39) |
K960I |
probably damaging |
Het |
| Cldn4 |
A |
G |
5: 134,975,343 (GRCm39) |
I86T |
probably benign |
Het |
| Cst12 |
A |
C |
2: 148,631,468 (GRCm39) |
D50A |
probably damaging |
Het |
| Dock10 |
A |
G |
1: 80,501,459 (GRCm39) |
Y1864H |
probably damaging |
Het |
| Dscaml1 |
G |
A |
9: 45,658,155 (GRCm39) |
G1642E |
probably benign |
Het |
| Jakmip3 |
T |
C |
7: 138,619,341 (GRCm39) |
L241P |
probably damaging |
Het |
| Kdm1a |
C |
T |
4: 136,281,202 (GRCm39) |
R669H |
probably damaging |
Het |
| Lin54 |
G |
A |
5: 100,601,876 (GRCm39) |
P455S |
probably damaging |
Het |
| Lrig1 |
A |
G |
6: 94,631,901 (GRCm39) |
Y100H |
probably benign |
Het |
| Lrig1 |
G |
A |
6: 94,586,874 (GRCm39) |
P601S |
probably damaging |
Het |
| Mtrf1 |
A |
G |
14: 79,660,865 (GRCm39) |
D419G |
probably benign |
Het |
| Naca |
C |
T |
10: 127,877,584 (GRCm39) |
|
probably benign |
Het |
| Naip1 |
A |
G |
13: 100,559,722 (GRCm39) |
L1094P |
probably damaging |
Het |
| Nell2 |
A |
T |
15: 95,127,064 (GRCm39) |
N770K |
probably damaging |
Het |
| Notch4 |
A |
G |
17: 34,800,000 (GRCm39) |
H987R |
possibly damaging |
Het |
| Or2a52 |
T |
A |
6: 43,144,324 (GRCm39) |
C111S |
probably damaging |
Het |
| Or5p63 |
T |
A |
7: 107,810,933 (GRCm39) |
I268F |
probably benign |
Het |
| Or7g26 |
T |
A |
9: 19,230,238 (GRCm39) |
M142K |
probably damaging |
Het |
| Pate13 |
T |
A |
9: 35,820,244 (GRCm39) |
C33* |
probably null |
Het |
| Plcg1 |
G |
T |
2: 160,595,813 (GRCm39) |
G561W |
probably damaging |
Het |
| Ripor3 |
T |
A |
2: 167,835,495 (GRCm39) |
M159L |
probably benign |
Het |
| Serpinb6a |
A |
G |
13: 34,109,400 (GRCm39) |
S111P |
possibly damaging |
Het |
| Tas1r3 |
A |
T |
4: 155,945,784 (GRCm39) |
H537Q |
probably benign |
Het |
| Tefm |
G |
A |
11: 80,028,823 (GRCm39) |
R43* |
probably null |
Het |
| Tiam1 |
A |
G |
16: 89,634,676 (GRCm39) |
V878A |
probably damaging |
Het |
| Vmn2r124 |
G |
T |
17: 18,293,733 (GRCm39) |
V607L |
probably benign |
Het |
| Vps8 |
T |
G |
16: 21,336,107 (GRCm39) |
|
probably null |
Het |
| Ythdf2 |
A |
T |
4: 131,932,661 (GRCm39) |
D166E |
possibly damaging |
Het |
| Zan |
A |
G |
5: 137,434,694 (GRCm39) |
V2203A |
unknown |
Het |
|
| Other mutations in Vmn1r203 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01527:Vmn1r203
|
APN |
13 |
22,708,447 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01808:Vmn1r203
|
APN |
13 |
22,708,717 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01887:Vmn1r203
|
APN |
13 |
22,709,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02340:Vmn1r203
|
APN |
13 |
22,708,997 (GRCm39) |
nonsense |
probably null |
|
|
IGL02543:Vmn1r203
|
APN |
13 |
22,709,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02684:Vmn1r203
|
APN |
13 |
22,708,539 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
BB005:Vmn1r203
|
UTSW |
13 |
22,708,705 (GRCm39) |
missense |
probably benign |
0.01 |
|
BB015:Vmn1r203
|
UTSW |
13 |
22,708,705 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4519001:Vmn1r203
|
UTSW |
13 |
22,708,765 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0544:Vmn1r203
|
UTSW |
13 |
22,708,443 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1365:Vmn1r203
|
UTSW |
13 |
22,708,756 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1396:Vmn1r203
|
UTSW |
13 |
22,708,678 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1794:Vmn1r203
|
UTSW |
13 |
22,708,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2010:Vmn1r203
|
UTSW |
13 |
22,708,617 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2169:Vmn1r203
|
UTSW |
13 |
22,708,905 (GRCm39) |
nonsense |
probably null |
|
|
R2333:Vmn1r203
|
UTSW |
13 |
22,709,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2418:Vmn1r203
|
UTSW |
13 |
22,709,004 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R2419:Vmn1r203
|
UTSW |
13 |
22,709,004 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R4322:Vmn1r203
|
UTSW |
13 |
22,708,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4460:Vmn1r203
|
UTSW |
13 |
22,708,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4686:Vmn1r203
|
UTSW |
13 |
22,708,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5526:Vmn1r203
|
UTSW |
13 |
22,708,273 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6240:Vmn1r203
|
UTSW |
13 |
22,708,899 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6607:Vmn1r203
|
UTSW |
13 |
22,708,891 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7575:Vmn1r203
|
UTSW |
13 |
22,708,588 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7928:Vmn1r203
|
UTSW |
13 |
22,708,705 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8375:Vmn1r203
|
UTSW |
13 |
22,709,154 (GRCm39) |
makesense |
probably null |
|
|
R8421:Vmn1r203
|
UTSW |
13 |
22,709,154 (GRCm39) |
makesense |
probably null |
|
|
R8424:Vmn1r203
|
UTSW |
13 |
22,709,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8845:Vmn1r203
|
UTSW |
13 |
22,708,720 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8933:Vmn1r203
|
UTSW |
13 |
22,708,691 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8956:Vmn1r203
|
UTSW |
13 |
22,709,004 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R9493:Vmn1r203
|
UTSW |
13 |
22,708,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn1r203
|
UTSW |
13 |
22,708,579 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Posted On |
2013-10-07 |
Incidental Mutation