Incidental Mutation 'IGL01356:Or5p63'
ID 75513
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5p63
Ensembl Gene ENSMUSG00000095929
Gene Name olfactory receptor family 5 subfamily P member 63
Synonyms GA_x6K02T2PBJ9-10541702-10540758, Olfr1538-ps1, MOR204-31P, MOR204-31P, Olfr487, MOR204-29P
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # IGL01356
Quality Score
Status
Chromosome 7
Chromosomal Location 107810790-107811734 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 107810933 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 268 (I268F)
Ref Sequence ENSEMBL: ENSMUSP00000149407 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081996] [ENSMUST00000216489]
AlphaFold Q7TRU9
Predicted Effect probably benign
Transcript: ENSMUST00000081996
AA Change: I268F

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000080657
Gene: ENSMUSG00000095929
AA Change: I268F

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 6.1e-50 PFAM
Pfam:7tm_1 44 293 1e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216489
AA Change: I268F

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA474408 T C 7: 109,660,189 (GRCm39) probably benign Het
Acsl1 T C 8: 46,964,500 (GRCm39) probably null Het
Adck2 T C 6: 39,560,854 (GRCm39) V463A probably benign Het
Armh3 C T 19: 45,954,742 (GRCm39) C149Y possibly damaging Het
B4galt4 T A 16: 38,574,506 (GRCm39) I224N probably damaging Het
Caprin1 T C 2: 103,605,801 (GRCm39) T396A probably benign Het
Cbx3 T C 6: 51,452,281 (GRCm39) V32A probably damaging Het
Chd1 A T 17: 15,970,127 (GRCm39) K960I probably damaging Het
Cldn4 A G 5: 134,975,343 (GRCm39) I86T probably benign Het
Cst12 A C 2: 148,631,468 (GRCm39) D50A probably damaging Het
Dock10 A G 1: 80,501,459 (GRCm39) Y1864H probably damaging Het
Dscaml1 G A 9: 45,658,155 (GRCm39) G1642E probably benign Het
Jakmip3 T C 7: 138,619,341 (GRCm39) L241P probably damaging Het
Kdm1a C T 4: 136,281,202 (GRCm39) R669H probably damaging Het
Lin54 G A 5: 100,601,876 (GRCm39) P455S probably damaging Het
Lrig1 A G 6: 94,631,901 (GRCm39) Y100H probably benign Het
Lrig1 G A 6: 94,586,874 (GRCm39) P601S probably damaging Het
Mtrf1 A G 14: 79,660,865 (GRCm39) D419G probably benign Het
Naca C T 10: 127,877,584 (GRCm39) probably benign Het
Naip1 A G 13: 100,559,722 (GRCm39) L1094P probably damaging Het
Nell2 A T 15: 95,127,064 (GRCm39) N770K probably damaging Het
Notch4 A G 17: 34,800,000 (GRCm39) H987R possibly damaging Het
Or2a52 T A 6: 43,144,324 (GRCm39) C111S probably damaging Het
Or7g26 T A 9: 19,230,238 (GRCm39) M142K probably damaging Het
Pate13 T A 9: 35,820,244 (GRCm39) C33* probably null Het
Plcg1 G T 2: 160,595,813 (GRCm39) G561W probably damaging Het
Ripor3 T A 2: 167,835,495 (GRCm39) M159L probably benign Het
Serpinb6a A G 13: 34,109,400 (GRCm39) S111P possibly damaging Het
Tas1r3 A T 4: 155,945,784 (GRCm39) H537Q probably benign Het
Tefm G A 11: 80,028,823 (GRCm39) R43* probably null Het
Tiam1 A G 16: 89,634,676 (GRCm39) V878A probably damaging Het
Vmn1r203 A G 13: 22,708,947 (GRCm39) S243G probably damaging Het
Vmn2r124 G T 17: 18,293,733 (GRCm39) V607L probably benign Het
Vps8 T G 16: 21,336,107 (GRCm39) probably null Het
Ythdf2 A T 4: 131,932,661 (GRCm39) D166E possibly damaging Het
Zan A G 5: 137,434,694 (GRCm39) V2203A unknown Het
Other mutations in Or5p63
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03133:Or5p63 APN 7 107,811,594 (GRCm39) missense possibly damaging 0.94
IGL03326:Or5p63 APN 7 107,810,837 (GRCm39) missense probably benign 0.03
R0141:Or5p63 UTSW 7 107,811,210 (GRCm39) missense possibly damaging 0.59
R0344:Or5p63 UTSW 7 107,810,949 (GRCm39) nonsense probably null
R0595:Or5p63 UTSW 7 107,810,868 (GRCm39) missense probably damaging 1.00
R1427:Or5p63 UTSW 7 107,811,301 (GRCm39) missense probably benign 0.07
R2023:Or5p63 UTSW 7 107,811,049 (GRCm39) missense probably damaging 1.00
R2065:Or5p63 UTSW 7 107,811,547 (GRCm39) missense probably damaging 0.98
R2068:Or5p63 UTSW 7 107,811,547 (GRCm39) missense probably damaging 0.98
R3410:Or5p63 UTSW 7 107,811,490 (GRCm39) missense possibly damaging 0.95
R4024:Or5p63 UTSW 7 107,810,949 (GRCm39) nonsense probably null
R4619:Or5p63 UTSW 7 107,811,301 (GRCm39) missense possibly damaging 0.78
R4738:Or5p63 UTSW 7 107,811,201 (GRCm39) missense probably damaging 0.99
R5004:Or5p63 UTSW 7 107,811,323 (GRCm39) nonsense probably null
R5684:Or5p63 UTSW 7 107,811,279 (GRCm39) nonsense probably null
R6782:Or5p63 UTSW 7 107,811,670 (GRCm39) missense probably benign 0.03
R6889:Or5p63 UTSW 7 107,811,125 (GRCm39) missense probably benign 0.00
R7010:Or5p63 UTSW 7 107,811,349 (GRCm39) missense probably damaging 0.98
R7076:Or5p63 UTSW 7 107,811,205 (GRCm39) missense probably damaging 1.00
R8162:Or5p63 UTSW 7 107,810,995 (GRCm39) missense probably damaging 1.00
R8190:Or5p63 UTSW 7 107,811,014 (GRCm39) missense possibly damaging 0.80
R9108:Or5p63 UTSW 7 107,810,846 (GRCm39) missense probably damaging 1.00
R9172:Or5p63 UTSW 7 107,811,169 (GRCm39) missense probably benign 0.12
Z1177:Or5p63 UTSW 7 107,811,176 (GRCm39) missense probably benign
Posted On 2013-10-07