Incidental Mutation 'IGL01356:Olfr437'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr437
Ensembl Gene ENSMUSG00000071481
Gene Nameolfactory receptor 437
SynonymsGA_x6K02T2P3E9-4391088-4390156, MOR261-11
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.112) question?
Stock #IGL01356
Quality Score
Chromosomal Location43163282-43169861 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 43167390 bp
Amino Acid Change Cysteine to Serine at position 111 (C111S)
Ref Sequence ENSEMBL: ENSMUSP00000145490 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060243] [ENSMUST00000205175] [ENSMUST00000216179]
Predicted Effect probably damaging
Transcript: ENSMUST00000060243
AA Change: C111S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000058147
Gene: ENSMUSG00000071481
AA Change: C111S

Pfam:7tm_4 30 307 7.5e-60 PFAM
Pfam:7tm_1 40 289 3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205175
AA Change: C111S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145490
Gene: ENSMUSG00000071481
AA Change: C111S

Pfam:7tm_4 30 307 7.5e-60 PFAM
Pfam:7tm_1 40 289 3e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216179
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130011E15Rik C T 19: 45,966,303 C149Y possibly damaging Het
9230113P08Rik T A 9: 35,908,948 C33* probably null Het
AA474408 T C 7: 110,060,982 probably benign Het
Acsl1 T C 8: 46,511,463 probably null Het
Adck2 T C 6: 39,583,920 V463A probably benign Het
B4galt4 T A 16: 38,754,144 I224N probably damaging Het
Caprin1 T C 2: 103,775,456 T396A probably benign Het
Cbx3 T C 6: 51,475,301 V32A probably damaging Het
Chd1 A T 17: 15,749,865 K960I probably damaging Het
Cldn4 A G 5: 134,946,489 I86T probably benign Het
Cst12 A C 2: 148,789,548 D50A probably damaging Het
Dock10 A G 1: 80,523,742 Y1864H probably damaging Het
Dscaml1 G A 9: 45,746,857 G1642E probably benign Het
Jakmip3 T C 7: 139,017,612 L241P probably damaging Het
Kdm1a C T 4: 136,553,891 R669H probably damaging Het
Lin54 G A 5: 100,454,017 P455S probably damaging Het
Lrig1 A G 6: 94,654,920 Y100H probably benign Het
Lrig1 G A 6: 94,609,893 P601S probably damaging Het
Mtrf1 A G 14: 79,423,425 D419G probably benign Het
Naca C T 10: 128,041,715 probably benign Het
Naip1 A G 13: 100,423,214 L1094P probably damaging Het
Nell2 A T 15: 95,229,183 N770K probably damaging Het
Notch4 A G 17: 34,581,026 H987R possibly damaging Het
Olfr487 T A 7: 108,211,726 I268F probably benign Het
Olfr844 T A 9: 19,318,942 M142K probably damaging Het
Plcg1 G T 2: 160,753,893 G561W probably damaging Het
Ripor3 T A 2: 167,993,575 M159L probably benign Het
Serpinb6a A G 13: 33,925,417 S111P possibly damaging Het
Tas1r3 A T 4: 155,861,327 H537Q probably benign Het
Tefm G A 11: 80,137,997 R43* probably null Het
Tiam1 A G 16: 89,837,788 V878A probably damaging Het
Vmn1r203 A G 13: 22,524,777 S243G probably damaging Het
Vmn2r124 G T 17: 18,073,471 V607L probably benign Het
Vps8 T G 16: 21,517,357 probably null Het
Ythdf2 A T 4: 132,205,350 D166E possibly damaging Het
Zan A G 5: 137,436,432 V2203A unknown Het
Other mutations in Olfr437
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01618:Olfr437 APN 6 43167703 missense probably damaging 0.97
IGL02426:Olfr437 APN 6 43167088 missense probably benign 0.02
R0548:Olfr437 UTSW 6 43167187 missense probably benign 0.43
R0856:Olfr437 UTSW 6 43167411 missense probably damaging 1.00
R1590:Olfr437 UTSW 6 43167912 missense probably damaging 1.00
R1902:Olfr437 UTSW 6 43167723 splice site probably null
R3894:Olfr437 UTSW 6 43167258 missense probably benign 0.23
R5083:Olfr437 UTSW 6 43167339 missense probably benign 0.33
R5278:Olfr437 UTSW 6 43167721 missense probably damaging 1.00
R6246:Olfr437 UTSW 6 43167502 splice site probably null
R6781:Olfr437 UTSW 6 43167388 missense probably damaging 1.00
R6807:Olfr437 UTSW 6 43167238 missense probably damaging 1.00
R7253:Olfr437 UTSW 6 43167810 missense probably damaging 1.00
R8445:Olfr437 UTSW 6 43167297 missense probably benign 0.36
Posted On2013-10-07