Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01360:Vmn2r112'

75688

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r112

Ensembl Gene

ENSMUSG00000094921

Gene Name

vomeronasal 2, receptor 112

Synonyms

EG628185

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.136) question?

Stock #

IGL01360

Quality Score

Status

Chromosome

Chromosomal Location

22601148-22619133 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22618622 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 688 (M688T)

Ref Sequence

ENSEMBL: ENSMUSP00000094994 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097381]

Predicted Effect

probably benign
Transcript: ENSMUST00000097381
AA Change: M688T

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000094994
Gene: ENSMUSG00000094921
AA Change: M688T

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.8e-32	PFAM
Pfam:NCD3G	512	565	5.8e-21	PFAM
Pfam:7tm_3	598	833	6.5e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6430573F11Rik	A	G	8: 36,512,559	I439V	probably benign	Het
Abca12	T	A	1: 71,286,489	I1517L	possibly damaging	Het
Akap12	A	T	10: 4,357,537	D1449V	probably benign	Het
Alg6	T	A	4: 99,742,406	Y161N	probably benign	Het
Arhgap45	A	T	10: 80,028,648		probably benign	Het
Arhgap5	A	T	12: 52,518,240	I665F	probably damaging	Het
Bbs4	A	G	9: 59,339,848	V123A	possibly damaging	Het
Carm1	C	T	9: 21,587,302	T480I	probably benign	Het
Catsperb	G	A	12: 101,625,254	V1032M	probably damaging	Het
Cdc42bpb	A	C	12: 111,342,075	I101S	probably damaging	Het
Copa	C	A	1: 172,087,588		probably null	Het
Cramp1l	T	C	17: 24,997,573	I189V	probably damaging	Het
Dhx33	G	A	11: 70,993,861	Q40*	probably null	Het
Egf	A	T	3: 129,740,020	F57Y	probably damaging	Het
Flt4	T	C	11: 49,643,506	I1168T	probably benign	Het
Gm12794	A	T	4: 101,940,468	D21V	possibly damaging	Het
Gm14178	A	G	11: 99,747,443	S37P	unknown	Het
Gpbp1	A	T	13: 111,426,541		probably benign	Het
Herc1	T	C	9: 66,483,699	S3980P	probably benign	Het
Itga6	T	C	2: 71,787,326		probably null	Het
Itgb4	T	C	11: 115,990,940	S772P	probably damaging	Het
Kcng4	C	A	8: 119,625,677	G498V	probably benign	Het
Lrp1	T	G	10: 127,545,820	D3795A	possibly damaging	Het
Lrrk2	T	A	15: 91,700,569		probably null	Het
Mettl25	A	T	10: 105,823,197	H408Q	probably damaging	Het
Mki67	T	C	7: 135,705,776	E457G	probably damaging	Het
Mpl	G	A	4: 118,455,661	T158I	possibly damaging	Het
Mtg2	C	T	2: 180,084,077	T160I	probably damaging	Het
Mtif2	A	G	11: 29,530,110	I59V	probably benign	Het
Ncapg	C	A	5: 45,674,385	S191*	probably null	Het
Nup214	T	C	2: 32,038,178		probably benign	Het
Olfr1154	T	C	2: 87,903,527	T50A	probably benign	Het
Phf3	T	A	1: 30,808,728	T1245S	probably damaging	Het
Piezo2	T	C	18: 63,117,699	D443G	probably damaging	Het
Ptchd4	C	A	17: 42,317,045	H132Q	probably benign	Het
Pum1	T	C	4: 130,728,170		probably benign	Het
Slc30a7	A	T	3: 115,990,116	V136E	probably damaging	Het
Slc5a10	A	G	11: 61,715,136	V116A	probably damaging	Het
Sos2	A	T	12: 69,590,800	S1046T	probably benign	Het
Svep1	A	G	4: 58,116,554	S899P	possibly damaging	Het
Tfr2	G	A	5: 137,571,691	V120I	probably benign	Het
Tnfrsf18	A	T	4: 156,028,036	R117*	probably null	Het
Vmn1r77	T	G	7: 12,041,388	F30L	probably benign	Het
Vmn2r93	T	A	17: 18,305,248	D389E	possibly damaging	Het
Zpld1	T	G	16: 55,226,385	N407T	probably benign	Het
Zranb3	C	T	1: 127,959,885	W935*	probably null	Het
Zyx	G	A	6: 42,350,444	R59Q	probably damaging	Het

Other mutations in Vmn2r112

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Vmn2r112	APN	17	22618936	missense	probably benign	0.13
IGL01021:Vmn2r112	APN	17	22618904	missense	probably damaging	1.00
IGL01122:Vmn2r112	APN	17	22603007	missense	probably benign	0.00
IGL01536:Vmn2r112	APN	17	22605155	missense	probably damaging	1.00
IGL02148:Vmn2r112	APN	17	22619032	missense	probably damaging	1.00
IGL02465:Vmn2r112	APN	17	22614994	missense	probably damaging	1.00
PIT4576001:Vmn2r112	UTSW	17	22614931	missense	probably benign	0.00
R0278:Vmn2r112	UTSW	17	22603006	missense	probably benign	0.44
R0328:Vmn2r112	UTSW	17	22605270	missense	probably benign	0.01
R0583:Vmn2r112	UTSW	17	22618949	missense	probably damaging	1.00
R0831:Vmn2r112	UTSW	17	22614999	missense	probably damaging	0.99
R1080:Vmn2r112	UTSW	17	22618999	missense	probably damaging	1.00
R1245:Vmn2r112	UTSW	17	22603247	missense	probably benign	0.03
R1321:Vmn2r112	UTSW	17	22618519	nonsense	probably null
R1381:Vmn2r112	UTSW	17	22618486	missense	probably damaging	1.00
R1514:Vmn2r112	UTSW	17	22602844	missense	probably benign	0.40
R1519:Vmn2r112	UTSW	17	22618903	missense	possibly damaging	0.83
R1572:Vmn2r112	UTSW	17	22603144	missense	possibly damaging	0.61
R1590:Vmn2r112	UTSW	17	22615008	critical splice donor site	probably null
R1640:Vmn2r112	UTSW	17	22605116	missense	probably benign	0.01
R2221:Vmn2r112	UTSW	17	22601233	missense	possibly damaging	0.86
R2223:Vmn2r112	UTSW	17	22601233	missense	possibly damaging	0.86
R2310:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2312:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2337:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2339:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2340:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2341:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2342:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2401:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2860:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2861:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2926:Vmn2r112	UTSW	17	22615003	missense	possibly damaging	0.90
R3236:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R3237:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R3977:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R3979:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R4168:Vmn2r112	UTSW	17	22603088	missense	probably benign	0.01
R4256:Vmn2r112	UTSW	17	22618412	missense	probably damaging	1.00
R4386:Vmn2r112	UTSW	17	22601322	missense	probably benign	0.36
R4912:Vmn2r112	UTSW	17	22603382	missense	probably damaging	0.99
R4947:Vmn2r112	UTSW	17	22602879	missense	probably benign	0.02
R5446:Vmn2r112	UTSW	17	22618250	missense	probably damaging	1.00
R5870:Vmn2r112	UTSW	17	22619023	missense	probably benign	0.00
R6351:Vmn2r112	UTSW	17	22601278	missense	probably benign
R6384:Vmn2r112	UTSW	17	22605155	missense	probably damaging	1.00
R6390:Vmn2r112	UTSW	17	22605249	missense	probably benign	0.01
R6401:Vmn2r112	UTSW	17	22603551	nonsense	probably null
R6405:Vmn2r112	UTSW	17	22618235	missense	probably damaging	1.00
R6620:Vmn2r112	UTSW	17	22603101	missense	probably benign	0.00
R6648:Vmn2r112	UTSW	17	22618486	missense	probably damaging	1.00
R6649:Vmn2r112	UTSW	17	22601179	missense	probably null	1.00
R6653:Vmn2r112	UTSW	17	22601179	missense	probably null	1.00
R6654:Vmn2r112	UTSW	17	22603469	missense	possibly damaging	0.89
R6700:Vmn2r112	UTSW	17	22603481	missense	possibly damaging	0.53
R6993:Vmn2r112	UTSW	17	22603214	missense	probably benign	0.01
R7052:Vmn2r112	UTSW	17	22602526	missense	probably benign
R7454:Vmn2r112	UTSW	17	22603307	missense	probably benign	0.00
R7763:Vmn2r112	UTSW	17	22603118	missense	probably damaging	1.00
R8032:Vmn2r112	UTSW	17	22603394	missense	probably benign	0.21
Z1088:Vmn2r112	UTSW	17	22605078	missense	possibly damaging	0.89

Posted On

2013-10-07