Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01363:Cyp2c67'

75814

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c67

Ensembl Gene

ENSMUSG00000062624

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 67

Synonyms

C730004C24Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL01363

Quality Score

Status

Chromosome

Chromosomal Location

39608842-39649051 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 39639967 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 178 (I178L)

Ref Sequence

ENSEMBL: ENSMUSP00000065796 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067328]

AlphaFold

Q569X9

Predicted Effect

probably damaging
Transcript: ENSMUST00000067328
AA Change: I178L

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000065796
Gene: ENSMUSG00000062624
AA Change: I178L

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	8.5e-150	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3100002H09Rik	A	G	4: 124,610,690	F23S	probably damaging	Het
A730017C20Rik	G	A	18: 59,072,308	G98D	probably damaging	Het
Abcg3	A	G	5: 104,948,362	V528A	possibly damaging	Het
Adgrv1	A	G	13: 81,557,065	V1542A	probably damaging	Het
Alkbh3	A	G	2: 94,003,051		probably null	Het
Ang4	G	T	14: 51,764,179	T104K	probably benign	Het
Arhgef3	T	A	14: 27,401,919	C532*	probably null	Het
Bnip3	G	A	7: 138,898,048	T70I	probably benign	Het
Cast	T	C	13: 74,704,192	E644G	possibly damaging	Het
Cenpc1	A	T	5: 86,046,531	C125*	probably null	Het
Crb2	C	A	2: 37,793,833	R1116S	probably benign	Het
Cyp2c68	T	A	19: 39,703,427	M351L	probably benign	Het
Dusp1	G	A	17: 26,506,290	P365L	probably damaging	Het
Gatb	T	C	3: 85,652,345	L492P	probably damaging	Het
Gm13103	A	T	4: 143,853,276	Y477F	probably benign	Het
Igkv8-19	T	C	6: 70,341,099	S48G	probably damaging	Het
Isyna1	G	A	8: 70,594,722	V32I	probably damaging	Het
Itgb6	T	A	2: 60,611,382	N695Y	possibly damaging	Het
Klra8	T	C	6: 130,115,598	T247A	probably benign	Het
Mak	G	A	13: 41,053,377		probably benign	Het
Mndal	T	A	1: 173,857,456	T516S	possibly damaging	Het
Mphosph9	G	T	5: 124,262,021	T939K	probably damaging	Het
Nfrkb	A	G	9: 31,414,371	T1037A	possibly damaging	Het
Olfr165	C	T	16: 19,407,583	M145I	probably benign	Het
Olfr25	A	G	9: 38,329,703	T39A	probably benign	Het
Pard3b	A	G	1: 62,637,640	Y1011C	probably damaging	Het
Parm1	G	A	5: 91,613,018	V250M	probably damaging	Het
Pgap2	T	G	7: 102,226,282	M1R	probably null	Het
Phlpp2	T	C	8: 109,937,097	F923L	probably benign	Het
Polr1a	T	A	6: 71,948,486	M739K	probably benign	Het
Pramel1	A	G	4: 143,397,385	Y210C	probably benign	Het
Raver2	A	G	4: 101,120,583		probably benign	Het
Rb1cc1	C	T	1: 6,250,109	L1251F	probably benign	Het
Ros1	T	A	10: 52,166,142	Y238F	probably damaging	Het
Shroom3	T	C	5: 92,940,993	L534P	probably benign	Het
Tjp1	A	T	7: 65,302,965	F1540L	possibly damaging	Het
Tmem200b	C	A	4: 131,922,393	P208Q	probably benign	Het
Tmem236	T	C	2: 14,174,630	L14P	probably damaging	Het
Tubgcp6	A	T	15: 89,107,525	I623N	probably damaging	Het
Vmn1r119	C	T	7: 21,012,131	V109I	probably benign	Het
Vmn2r98	A	G	17: 19,065,758	N173D	probably benign	Het

Other mutations in Cyp2c67

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00955:Cyp2c67	APN	19	39643385	missense	possibly damaging	0.95
IGL01025:Cyp2c67	APN	19	39639932	nonsense	probably null
IGL01819:Cyp2c67	APN	19	39615721	missense	probably damaging	0.98
IGL01902:Cyp2c67	APN	19	39649026	missense	probably damaging	1.00
IGL02172:Cyp2c67	APN	19	39649002	missense	possibly damaging	0.76
IGL02351:Cyp2c67	APN	19	39617417	missense	probably damaging	1.00
IGL02355:Cyp2c67	APN	19	39643405	missense	probably benign	0.34
IGL02355:Cyp2c67	APN	19	39617382	nonsense	probably null
IGL02358:Cyp2c67	APN	19	39617417	missense	probably damaging	1.00
IGL02362:Cyp2c67	APN	19	39643405	missense	probably benign	0.34
IGL02362:Cyp2c67	APN	19	39617382	nonsense	probably null
IGL02388:Cyp2c67	APN	19	39643355	missense	probably benign	0.20
IGL03106:Cyp2c67	APN	19	39643675	missense	probably benign	0.27
IGL03219:Cyp2c67	APN	19	39643294	missense	possibly damaging	0.54
IGL03326:Cyp2c67	APN	19	39643269	critical splice donor site	probably null
IGL03349:Cyp2c67	APN	19	39643684	missense	probably damaging	1.00
IGL03356:Cyp2c67	APN	19	39639961	missense	probably damaging	1.00
IGL03052:Cyp2c67	UTSW	19	39648885	missense	possibly damaging	0.88
R0585:Cyp2c67	UTSW	19	39638694	missense	possibly damaging	0.59
R0975:Cyp2c67	UTSW	19	39609178	missense	possibly damaging	0.49
R0976:Cyp2c67	UTSW	19	39643374	missense	probably damaging	1.00
R1252:Cyp2c67	UTSW	19	39626141	missense	possibly damaging	0.93
R1398:Cyp2c67	UTSW	19	39638625	missense	probably damaging	0.96
R1411:Cyp2c67	UTSW	19	39638591	missense	probably damaging	1.00
R1505:Cyp2c67	UTSW	19	39648964	missense	probably benign	0.00
R1543:Cyp2c67	UTSW	19	39643264	splice site	probably benign
R1613:Cyp2c67	UTSW	19	39626199	missense	probably benign	0.00
R1618:Cyp2c67	UTSW	19	39643264	splice site	probably benign
R1667:Cyp2c67	UTSW	19	39643590	critical splice donor site	probably null
R1852:Cyp2c67	UTSW	19	39617367	missense	probably benign	0.01
R2005:Cyp2c67	UTSW	19	39643345	missense	probably damaging	1.00
R2105:Cyp2c67	UTSW	19	39626237	missense	probably benign	0.24
R2181:Cyp2c67	UTSW	19	39609097	missense	possibly damaging	0.94
R3817:Cyp2c67	UTSW	19	39638683	missense	probably benign	0.00
R4669:Cyp2c67	UTSW	19	39643654	missense	probably benign	0.00
R4689:Cyp2c67	UTSW	19	39638588	missense	probably benign	0.00
R4756:Cyp2c67	UTSW	19	39643744	missense	probably benign	0.03
R4823:Cyp2c67	UTSW	19	39615724	missense	probably benign	0.13
R5152:Cyp2c67	UTSW	19	39638688	missense	probably benign	0.00
R5345:Cyp2c67	UTSW	19	39626232	missense	probably benign	0.01
R5580:Cyp2c67	UTSW	19	39615650	missense	probably damaging	0.99
R5644:Cyp2c67	UTSW	19	39615694	missense	possibly damaging	0.84
R6116:Cyp2c67	UTSW	19	39617435	missense	probably damaging	1.00
R6516:Cyp2c67	UTSW	19	39617429	missense	probably damaging	1.00
R6550:Cyp2c67	UTSW	19	39617410	nonsense	probably null
R6939:Cyp2c67	UTSW	19	39643334	missense	possibly damaging	0.68
R6995:Cyp2c67	UTSW	19	39615679	missense	probably damaging	0.96
R7028:Cyp2c67	UTSW	19	39639897	missense	possibly damaging	0.68
R7144:Cyp2c67	UTSW	19	39615694	missense	probably benign	0.00
R7242:Cyp2c67	UTSW	19	39617339	missense	probably benign	0.30
R7335:Cyp2c67	UTSW	19	39640007	nonsense	probably null
R7337:Cyp2c67	UTSW	19	39609264	splice site	probably null
R7474:Cyp2c67	UTSW	19	39617432	missense	probably null	0.05
R7642:Cyp2c67	UTSW	19	39615640	missense	probably damaging	0.97
R7870:Cyp2c67	UTSW	19	39609225	missense	probably damaging	1.00
R8152:Cyp2c67	UTSW	19	39640008	missense	probably benign	0.21
R8367:Cyp2c67	UTSW	19	39638674	missense	probably benign	0.01
R8717:Cyp2c67	UTSW	19	39638711	missense	probably benign	0.05
R8728:Cyp2c67	UTSW	19	39626161	missense	probably damaging	1.00
R9275:Cyp2c67	UTSW	19	39609255	missense	probably damaging	1.00
R9278:Cyp2c67	UTSW	19	39609255	missense	probably damaging	1.00
R9376:Cyp2c67	UTSW	19	39638734	missense	probably damaging	1.00
Z1177:Cyp2c67	UTSW	19	39643679	missense	possibly damaging	0.89

Posted On

2013-10-07