Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01363:Tmem236'

75829

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem236

Ensembl Gene

ENSMUSG00000061531

Gene Name

transmembrane protein 236

Synonyms

Fam23a, 2010003H20Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL01363

Quality Score

Status

Chromosome

Chromosomal Location

14179335-14226804 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 14179441 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 14 (L14P)

Ref Sequence

ENSEMBL: ENSMUSP00000076722 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077517]

AlphaFold

A2ARJ3

Predicted Effect

probably damaging
Transcript: ENSMUST00000077517
AA Change: L14P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000076722
Gene: ENSMUSG00000061531
AA Change: L14P

Domain	Start	End	E-Value	Type
transmembrane domain	10	32	N/A	INTRINSIC
transmembrane domain	45	67	N/A	INTRINSIC
transmembrane domain	82	104	N/A	INTRINSIC
low complexity region	119	143	N/A	INTRINSIC
transmembrane domain	256	275	N/A	INTRINSIC
transmembrane domain	295	314	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3100002H09Rik	A	G	4: 124,504,483 (GRCm39)	F23S	probably damaging	Het
Abcg3	A	G	5: 105,096,228 (GRCm39)	V528A	possibly damaging	Het
Adgrv1	A	G	13: 81,705,184 (GRCm39)	V1542A	probably damaging	Het
Alkbh3	A	G	2: 93,833,396 (GRCm39)		probably null	Het
Ang4	G	T	14: 52,001,636 (GRCm39)	T104K	probably benign	Het
Arhgef3	T	A	14: 27,123,876 (GRCm39)	C532*	probably null	Het
Bnip3	G	A	7: 138,499,777 (GRCm39)	T70I	probably benign	Het
Cast	T	C	13: 74,852,311 (GRCm39)	E644G	possibly damaging	Het
Cenpc1	A	T	5: 86,194,390 (GRCm39)	C125*	probably null	Het
Crb2	C	A	2: 37,683,845 (GRCm39)	R1116S	probably benign	Het
Cyp2c67	T	G	19: 39,628,411 (GRCm39)	I178L	probably damaging	Het
Cyp2c68	T	A	19: 39,691,871 (GRCm39)	M351L	probably benign	Het
Dusp1	G	A	17: 26,725,264 (GRCm39)	P365L	probably damaging	Het
Gatb	T	C	3: 85,559,652 (GRCm39)	L492P	probably damaging	Het
Igkv8-19	T	C	6: 70,318,083 (GRCm39)	S48G	probably damaging	Het
Isyna1	G	A	8: 71,047,372 (GRCm39)	V32I	probably damaging	Het
Itgb6	T	A	2: 60,441,726 (GRCm39)	N695Y	possibly damaging	Het
Klra8	T	C	6: 130,092,561 (GRCm39)	T247A	probably benign	Het
Mak	G	A	13: 41,206,853 (GRCm39)		probably benign	Het
Minar2	G	A	18: 59,205,380 (GRCm39)	G98D	probably damaging	Het
Mndal	T	A	1: 173,685,022 (GRCm39)	T516S	possibly damaging	Het
Mphosph9	G	T	5: 124,400,084 (GRCm39)	T939K	probably damaging	Het
Nfrkb	A	G	9: 31,325,667 (GRCm39)	T1037A	possibly damaging	Het
Or2m13	C	T	16: 19,226,333 (GRCm39)	M145I	probably benign	Het
Or8c9	A	G	9: 38,240,999 (GRCm39)	T39A	probably benign	Het
Pard3b	A	G	1: 62,676,799 (GRCm39)	Y1011C	probably damaging	Het
Parm1	G	A	5: 91,760,877 (GRCm39)	V250M	probably damaging	Het
Pgap2	T	G	7: 101,875,489 (GRCm39)	M1R	probably null	Het
Phlpp2	T	C	8: 110,663,729 (GRCm39)	F923L	probably benign	Het
Polr1a	T	A	6: 71,925,470 (GRCm39)	M739K	probably benign	Het
Pramel1	A	G	4: 143,123,955 (GRCm39)	Y210C	probably benign	Het
Pramel27	A	T	4: 143,579,846 (GRCm39)	Y477F	probably benign	Het
Raver2	A	G	4: 100,977,780 (GRCm39)		probably benign	Het
Rb1cc1	C	T	1: 6,320,333 (GRCm39)	L1251F	probably benign	Het
Ros1	T	A	10: 52,042,238 (GRCm39)	Y238F	probably damaging	Het
Shroom3	T	C	5: 93,088,852 (GRCm39)	L534P	probably benign	Het
Tjp1	A	T	7: 64,952,713 (GRCm39)	F1540L	possibly damaging	Het
Tmem200b	C	A	4: 131,649,704 (GRCm39)	P208Q	probably benign	Het
Tubgcp6	A	T	15: 88,991,728 (GRCm39)	I623N	probably damaging	Het
Vmn1r119	C	T	7: 20,746,056 (GRCm39)	V109I	probably benign	Het
Vmn2r98	A	G	17: 19,286,020 (GRCm39)	N173D	probably benign	Het

Other mutations in Tmem236

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00490:Tmem236	APN	2	14,224,189 (GRCm39)	missense	probably damaging	1.00
IGL01980:Tmem236	APN	2	14,223,716 (GRCm39)	missense	probably benign	0.16
IGL02749:Tmem236	APN	2	14,224,132 (GRCm39)	missense	probably damaging	1.00
R0172:Tmem236	UTSW	2	14,223,694 (GRCm39)	missense	probably benign	0.06
R1470:Tmem236	UTSW	2	14,223,732 (GRCm39)	missense	probably benign	0.22
R1470:Tmem236	UTSW	2	14,223,732 (GRCm39)	missense	probably benign	0.22
R1519:Tmem236	UTSW	2	14,197,091 (GRCm39)	missense	probably benign	0.00
R1923:Tmem236	UTSW	2	14,224,117 (GRCm39)	missense	probably damaging	1.00
R2147:Tmem236	UTSW	2	14,223,861 (GRCm39)	missense	probably benign	0.03
R4226:Tmem236	UTSW	2	14,179,437 (GRCm39)	nonsense	probably null
R4551:Tmem236	UTSW	2	14,223,964 (GRCm39)	missense	probably benign	0.02
R4904:Tmem236	UTSW	2	14,200,803 (GRCm39)	missense	probably benign
R5168:Tmem236	UTSW	2	14,197,139 (GRCm39)	critical splice donor site	probably null
R5283:Tmem236	UTSW	2	14,179,644 (GRCm39)	missense	probably benign	0.01
R5306:Tmem236	UTSW	2	14,223,975 (GRCm39)	nonsense	probably null
R5334:Tmem236	UTSW	2	14,223,871 (GRCm39)	missense	possibly damaging	0.85
R6516:Tmem236	UTSW	2	14,200,791 (GRCm39)	missense	probably benign	0.00
R6604:Tmem236	UTSW	2	14,179,512 (GRCm39)	missense	probably benign	0.03
R7689:Tmem236	UTSW	2	14,197,076 (GRCm39)	missense	probably damaging	0.99
R8390:Tmem236	UTSW	2	14,224,168 (GRCm39)	missense	probably damaging	1.00
R9157:Tmem236	UTSW	2	14,223,889 (GRCm39)	missense	probably benign	0.00
R9630:Tmem236	UTSW	2	14,223,815 (GRCm39)	missense	probably benign
X0062:Tmem236	UTSW	2	14,224,089 (GRCm39)	missense	probably damaging	1.00
Z1177:Tmem236	UTSW	2	14,179,538 (GRCm39)	nonsense	probably null

Posted On

2013-10-07