Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01365:Myb'

75899

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Myb

Ensembl Gene

ENSMUSG00000019982

Gene Name

myeloblastosis oncogene

Synonyms

c-myb

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01365

Quality Score

Status

Chromosome

Chromosomal Location

21124935-21160984 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 21152502 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 154 (I154T)

Ref Sequence

ENSEMBL: ENSMUSP00000139699 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020158] [ENSMUST00000188495]

AlphaFold

P06876

Predicted Effect

probably benign
Transcript: ENSMUST00000020158
AA Change: I154T

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000020158
Gene: ENSMUSG00000019982
AA Change: I154T

Domain	Start	End	E-Value	Type
low complexity region	7	27	N/A	INTRINSIC
SANT	39	88	9.52e-20	SMART
SANT	91	140	2.04e-19	SMART
SANT	143	191	1.75e-18	SMART
low complexity region	227	239	N/A	INTRINSIC
Pfam:LMSTEN	267	313	4e-29	PFAM
Pfam:Cmyb_C	399	559	1.5e-64	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180680

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186446

Predicted Effect

probably benign
Transcript: ENSMUST00000188495
AA Change: I154T

PolyPhen 2 Score 0.305 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000139699
Gene: ENSMUSG00000019982
AA Change: I154T

Domain	Start	End	E-Value	Type
low complexity region	7	27	N/A	INTRINSIC
SANT	39	88	9.52e-20	SMART
SANT	91	140	2.04e-19	SMART
SANT	143	191	1.75e-18	SMART
low complexity region	227	239	N/A	INTRINSIC
Pfam:LMSTEN	266	313	3.6e-32	PFAM
low complexity region	409	421	N/A	INTRINSIC
Pfam:Cmyb_C	516	682	8.5e-66	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214539

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216751

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for deficient alleles of this gene display severe hematopoietic abnormalities. Red and white blood cells and platelets are all affected. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgre5	G	T	8: 83,723,889		probably null	Het
Agtr1a	A	G	13: 30,381,828	Y292C	probably damaging	Het
Btbd11	T	C	10: 85,633,816	V867A	possibly damaging	Het
CK137956	A	G	4: 127,951,342	S203P	probably benign	Het
Cnbd1	C	T	4: 18,860,576	G390D	probably damaging	Het
Cttnbp2nl	T	C	3: 105,005,030	T513A	probably damaging	Het
Dppa2	A	G	16: 48,313,913	K67R	possibly damaging	Het
Kif3a	A	G	11: 53,593,523	K486E	possibly damaging	Het
Lmnb2	G	T	10: 80,904,984	Q151K	probably benign	Het
Lmtk3	T	A	7: 45,790,907	L223Q	probably damaging	Het
Lrrk1	A	G	7: 66,287,701	I901T	probably damaging	Het
Macf1	T	C	4: 123,391,169	Y3624C	probably damaging	Het
Mios	T	A	6: 8,216,089	Y428*	probably null	Het
Olfr294	T	C	7: 86,615,997	Y216C	probably damaging	Het
Parp9	C	T	16: 35,947,954	T168I	possibly damaging	Het
Pramel7	T	C	2: 87,491,413		probably benign	Het
Ptar1	T	A	19: 23,705,801	W140R	probably damaging	Het
Sec14l2	G	T	11: 4,098,317	D400E	probably benign	Het
Setd3	A	T	12: 108,157,906	Y175N	probably damaging	Het
Slc5a8	C	T	10: 88,892,097		probably benign	Het
Slc8a3	A	G	12: 81,315,376	V223A	probably damaging	Het
Srsf1	G	T	11: 88,049,181	R173L	possibly damaging	Het
Svep1	T	A	4: 58,100,878		probably null	Het
Tead2	T	A	7: 45,217,251	D11E	probably damaging	Het
Trappc12	T	A	12: 28,747,402	I44F	probably damaging	Het
Ttll9	T	C	2: 153,000,134	Y303H	possibly damaging	Het
Vmn1r28	T	A	6: 58,265,191	N6K	possibly damaging	Het

Other mutations in Myb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00654:Myb	APN	10	21141826	missense	probably damaging	0.99
IGL00707:Myb	APN	10	21148384	missense	probably damaging	1.00
IGL00796:Myb	APN	10	21141799	missense	probably benign	0.00
IGL01012:Myb	APN	10	21146260	missense	probably benign	0.03
IGL01082:Myb	APN	10	21152944	missense	probably damaging	1.00
IGL01906:Myb	APN	10	21152634	missense	probably damaging	1.00
IGL02560:Myb	APN	10	21152448	missense	probably damaging	1.00
Huang_river	UTSW	10	21152617	missense	probably damaging	1.00
PIT4495001:Myb	UTSW	10	21152622	missense	probably damaging	0.98
R0385:Myb	UTSW	10	21154712	missense	possibly damaging	0.73
R0442:Myb	UTSW	10	21126196	missense	probably benign	0.05
R0759:Myb	UTSW	10	21145028	missense	probably benign	0.01
R0882:Myb	UTSW	10	21156360	missense	possibly damaging	0.75
R0920:Myb	UTSW	10	21126234	missense	possibly damaging	0.80
R1401:Myb	UTSW	10	21152945	missense	probably damaging	1.00
R1651:Myb	UTSW	10	21126198	missense	probably damaging	1.00
R1752:Myb	UTSW	10	21156437	missense	possibly damaging	0.89
R1879:Myb	UTSW	10	21141977	missense	probably benign	0.24
R1971:Myb	UTSW	10	21140656	missense	probably benign	0.00
R4355:Myb	UTSW	10	21152617	missense	probably damaging	1.00
R4611:Myb	UTSW	10	21145324	missense	probably damaging	1.00
R4650:Myb	UTSW	10	21152941	missense	probably damaging	1.00
R4888:Myb	UTSW	10	21126238	missense	probably benign	0.01
R5121:Myb	UTSW	10	21126238	missense	probably benign	0.01
R5922:Myb	UTSW	10	21152927	missense	probably damaging	1.00
R5955:Myb	UTSW	10	21152499	missense	probably damaging	1.00
R6116:Myb	UTSW	10	21154754	missense	probably damaging	1.00
R6150:Myb	UTSW	10	21141769	missense	probably damaging	1.00
R6207:Myb	UTSW	10	21145322	missense	probably benign
R6656:Myb	UTSW	10	21152945	missense	probably damaging	1.00
R6801:Myb	UTSW	10	21144966	splice site	probably null
R6824:Myb	UTSW	10	21145120	missense	probably benign	0.00
R6884:Myb	UTSW	10	21152532	missense	probably damaging	1.00
R6977:Myb	UTSW	10	21152652	missense	probably damaging	0.96
R7562:Myb	UTSW	10	21141754	splice site	probably null
R7651:Myb	UTSW	10	21156374	missense	probably damaging	1.00
R7747:Myb	UTSW	10	21156425	missense	possibly damaging	0.89
R8346:Myb	UTSW	10	21126237	missense	probably benign	0.00
R8683:Myb	UTSW	10	21150506	missense	possibly damaging	0.53
R8829:Myb	UTSW	10	21145231	missense	probably damaging	0.96
R9227:Myb	UTSW	10	21154713	missense	probably benign	0.03
R9228:Myb	UTSW	10	21154713	missense	probably benign	0.03
R9240:Myb	UTSW	10	21140601	missense	probably damaging	1.00
R9304:Myb	UTSW	10	21152617	missense	probably damaging	1.00
R9408:Myb	UTSW	10	21150376	missense	probably benign	0.21

Posted On

2013-10-07