Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01365:Vmn1r28'

75902

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r28

Ensembl Gene

ENSMUSG00000115705

Gene Name

vomeronasal 1 receptor 28

Synonyms

V1rc25

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.151) question?

Stock #

IGL01365

Quality Score

Status

Chromosome

Chromosomal Location

58262037-58275639 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 58265191 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 6 (N6K)

Ref Sequence

ENSEMBL: ENSMUSP00000153785 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176874] [ENSMUST00000226813] [ENSMUST00000227805] [ENSMUST00000228678]

AlphaFold

Q8R2C9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000176874
AA Change: N6K

PolyPhen 2 Score 0.757 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000135311
Gene: ENSMUSG00000094291
AA Change: N6K

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	8.4e-59	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000226813
AA Change: N6K

PolyPhen 2 Score 0.757 (Sensitivity: 0.85; Specificity: 0.92)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000227805
AA Change: N6K

PolyPhen 2 Score 0.757 (Sensitivity: 0.85; Specificity: 0.92)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228678
AA Change: N6K

PolyPhen 2 Score 0.757 (Sensitivity: 0.85; Specificity: 0.92)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgre5	G	T	8: 83,723,889		probably null	Het
Agtr1a	A	G	13: 30,381,828	Y292C	probably damaging	Het
Btbd11	T	C	10: 85,633,816	V867A	possibly damaging	Het
CK137956	A	G	4: 127,951,342	S203P	probably benign	Het
Cnbd1	C	T	4: 18,860,576	G390D	probably damaging	Het
Cttnbp2nl	T	C	3: 105,005,030	T513A	probably damaging	Het
Dppa2	A	G	16: 48,313,913	K67R	possibly damaging	Het
Kif3a	A	G	11: 53,593,523	K486E	possibly damaging	Het
Lmnb2	G	T	10: 80,904,984	Q151K	probably benign	Het
Lmtk3	T	A	7: 45,790,907	L223Q	probably damaging	Het
Lrrk1	A	G	7: 66,287,701	I901T	probably damaging	Het
Macf1	T	C	4: 123,391,169	Y3624C	probably damaging	Het
Mios	T	A	6: 8,216,089	Y428*	probably null	Het
Myb	A	G	10: 21,152,502	I154T	probably benign	Het
Olfr294	T	C	7: 86,615,997	Y216C	probably damaging	Het
Parp9	C	T	16: 35,947,954	T168I	possibly damaging	Het
Pramel7	T	C	2: 87,491,413		probably benign	Het
Ptar1	T	A	19: 23,705,801	W140R	probably damaging	Het
Sec14l2	G	T	11: 4,098,317	D400E	probably benign	Het
Setd3	A	T	12: 108,157,906	Y175N	probably damaging	Het
Slc5a8	C	T	10: 88,892,097		probably benign	Het
Slc8a3	A	G	12: 81,315,376	V223A	probably damaging	Het
Srsf1	G	T	11: 88,049,181	R173L	possibly damaging	Het
Svep1	T	A	4: 58,100,878		probably null	Het
Tead2	T	A	7: 45,217,251	D11E	probably damaging	Het
Trappc12	T	A	12: 28,747,402	I44F	probably damaging	Het
Ttll9	T	C	2: 153,000,134	Y303H	possibly damaging	Het

Other mutations in Vmn1r28

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01712:Vmn1r28	APN	6	58265408	missense	probably benign	0.00
IGL01788:Vmn1r28	APN	6	58265537	missense	probably benign	0.00
IGL02629:Vmn1r28	APN	6	58265816	missense	probably benign	0.00
R0001:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0009:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0040:Vmn1r28	UTSW	6	58265894	missense	probably damaging	1.00
R0078:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0079:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0081:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0164:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0164:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0165:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0166:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0167:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0172:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0173:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0284:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0288:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R0704:Vmn1r28	UTSW	6	58265717	missense	probably benign	0.00
R1143:Vmn1r28	UTSW	6	58265742	missense	probably benign	0.00
R1225:Vmn1r28	UTSW	6	58265966	nonsense	probably null
R1464:Vmn1r28	UTSW	6	58265232	missense	probably benign	0.05
R1464:Vmn1r28	UTSW	6	58265232	missense	probably benign	0.05
R1836:Vmn1r28	UTSW	6	58265252	missense	probably damaging	0.98
R1882:Vmn1r28	UTSW	6	58265978	missense	probably benign
R1905:Vmn1r28	UTSW	6	58265927	missense	probably benign	0.01
R4912:Vmn1r28	UTSW	6	58265540	missense	possibly damaging	0.86
R5071:Vmn1r28	UTSW	6	58265909	missense	probably benign	0.25
R5113:Vmn1r28	UTSW	6	58265858	missense	probably benign	0.12
R5261:Vmn1r28	UTSW	6	58265539	missense	probably benign	0.02
R5265:Vmn1r28	UTSW	6	58265964	missense	probably damaging	0.98
R5839:Vmn1r28	UTSW	6	58265295	missense	possibly damaging	0.94
R6180:Vmn1r28	UTSW	6	58265491	missense	probably damaging	0.99
R6643:Vmn1r28	UTSW	6	58265960	missense	probably benign	0.17
R6884:Vmn1r28	UTSW	6	58265648	missense	probably benign	0.03
R7393:Vmn1r28	UTSW	6	58265589	missense	possibly damaging	0.81
R7471:Vmn1r28	UTSW	6	58265865	nonsense	probably null
R7738:Vmn1r28	UTSW	6	58266054	missense	probably benign	0.00
R7961:Vmn1r28	UTSW	6	58265193	missense	probably benign
R8009:Vmn1r28	UTSW	6	58265193	missense	probably benign
R8156:Vmn1r28	UTSW	6	58265198	missense	probably damaging	1.00
R8167:Vmn1r28	UTSW	6	58266067	missense	noncoding transcript
R8879:Vmn1r28	UTSW	6	58265684	missense	probably benign	0.05

Posted On

2013-10-07