Incidental Mutation 'IGL01365:Vmn1r28'
| ID |
75902 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r28
|
| Ensembl Gene |
ENSMUSG00000115705 |
| Gene Name |
vomeronasal 1 receptor 28 |
| Synonyms |
V1rc25 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.120)
|
| Stock # |
IGL01365
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
58239279-58243645 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 58242176 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 6
(N6K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153785
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176874]
[ENSMUST00000226813]
[ENSMUST00000227805]
[ENSMUST00000228678]
|
| AlphaFold |
Q8R2C9 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000176874
AA Change: N6K
PolyPhen 2
Score 0.757 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000135311
Gene: ENSMUSG00000094291
AA Change: N6K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
8.4e-59 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226813
AA Change: N6K
PolyPhen 2
Score 0.757 (Sensitivity: 0.85; Specificity: 0.92)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227805
AA Change: N6K
PolyPhen 2
Score 0.757 (Sensitivity: 0.85; Specificity: 0.92)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228678
AA Change: N6K
PolyPhen 2
Score 0.757 (Sensitivity: 0.85; Specificity: 0.92)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abtb3 |
T |
C |
10: 85,469,680 (GRCm39) |
V867A |
possibly damaging |
Het |
| Adgre5 |
G |
T |
8: 84,450,518 (GRCm39) |
|
probably null |
Het |
| Agtr1a |
A |
G |
13: 30,565,811 (GRCm39) |
Y292C |
probably damaging |
Het |
| CK137956 |
A |
G |
4: 127,845,135 (GRCm39) |
S203P |
probably benign |
Het |
| Cnbd1 |
C |
T |
4: 18,860,576 (GRCm39) |
G390D |
probably damaging |
Het |
| Cttnbp2nl |
T |
C |
3: 104,912,346 (GRCm39) |
T513A |
probably damaging |
Het |
| Dppa2 |
A |
G |
16: 48,134,276 (GRCm39) |
K67R |
possibly damaging |
Het |
| Kif3a |
A |
G |
11: 53,484,350 (GRCm39) |
K486E |
possibly damaging |
Het |
| Lmnb2 |
G |
T |
10: 80,740,818 (GRCm39) |
Q151K |
probably benign |
Het |
| Lmtk3 |
T |
A |
7: 45,440,331 (GRCm39) |
L223Q |
probably damaging |
Het |
| Lrrk1 |
A |
G |
7: 65,937,449 (GRCm39) |
I901T |
probably damaging |
Het |
| Macf1 |
T |
C |
4: 123,284,962 (GRCm39) |
Y3624C |
probably damaging |
Het |
| Mios |
T |
A |
6: 8,216,089 (GRCm39) |
Y428* |
probably null |
Het |
| Myb |
A |
G |
10: 21,028,401 (GRCm39) |
I154T |
probably benign |
Het |
| Or14a256 |
T |
C |
7: 86,265,205 (GRCm39) |
Y216C |
probably damaging |
Het |
| Parp9 |
C |
T |
16: 35,768,324 (GRCm39) |
T168I |
possibly damaging |
Het |
| Pramel7 |
T |
C |
2: 87,321,757 (GRCm39) |
|
probably benign |
Het |
| Ptar1 |
T |
A |
19: 23,683,165 (GRCm39) |
W140R |
probably damaging |
Het |
| Sec14l2 |
G |
T |
11: 4,048,317 (GRCm39) |
D400E |
probably benign |
Het |
| Setd3 |
A |
T |
12: 108,124,165 (GRCm39) |
Y175N |
probably damaging |
Het |
| Slc5a8 |
C |
T |
10: 88,727,959 (GRCm39) |
|
probably benign |
Het |
| Slc8a3 |
A |
G |
12: 81,362,150 (GRCm39) |
V223A |
probably damaging |
Het |
| Srsf1 |
G |
T |
11: 87,940,007 (GRCm39) |
R173L |
possibly damaging |
Het |
| Svep1 |
T |
A |
4: 58,100,878 (GRCm39) |
|
probably null |
Het |
| Tead2 |
T |
A |
7: 44,866,675 (GRCm39) |
D11E |
probably damaging |
Het |
| Trappc12 |
T |
A |
12: 28,797,401 (GRCm39) |
I44F |
probably damaging |
Het |
| Ttll9 |
T |
C |
2: 152,842,054 (GRCm39) |
Y303H |
possibly damaging |
Het |
|
| Other mutations in Vmn1r28 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01712:Vmn1r28
|
APN |
6 |
58,242,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01788:Vmn1r28
|
APN |
6 |
58,242,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02629:Vmn1r28
|
APN |
6 |
58,242,801 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0001:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0009:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0040:Vmn1r28
|
UTSW |
6 |
58,242,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0078:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0079:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0081:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0165:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0166:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0167:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0172:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0173:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0284:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0288:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0704:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1143:Vmn1r28
|
UTSW |
6 |
58,242,727 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1225:Vmn1r28
|
UTSW |
6 |
58,242,951 (GRCm39) |
nonsense |
probably null |
|
|
R1464:Vmn1r28
|
UTSW |
6 |
58,242,217 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1464:Vmn1r28
|
UTSW |
6 |
58,242,217 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1836:Vmn1r28
|
UTSW |
6 |
58,242,237 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1882:Vmn1r28
|
UTSW |
6 |
58,242,963 (GRCm39) |
missense |
probably benign |
|
|
R1905:Vmn1r28
|
UTSW |
6 |
58,242,912 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4912:Vmn1r28
|
UTSW |
6 |
58,242,525 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5071:Vmn1r28
|
UTSW |
6 |
58,242,894 (GRCm39) |
missense |
probably benign |
0.25 |
|
R5113:Vmn1r28
|
UTSW |
6 |
58,242,843 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5261:Vmn1r28
|
UTSW |
6 |
58,242,524 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5265:Vmn1r28
|
UTSW |
6 |
58,242,949 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5839:Vmn1r28
|
UTSW |
6 |
58,242,280 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6180:Vmn1r28
|
UTSW |
6 |
58,242,476 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6643:Vmn1r28
|
UTSW |
6 |
58,242,945 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6884:Vmn1r28
|
UTSW |
6 |
58,242,633 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7393:Vmn1r28
|
UTSW |
6 |
58,242,574 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7471:Vmn1r28
|
UTSW |
6 |
58,242,850 (GRCm39) |
nonsense |
probably null |
|
|
R7738:Vmn1r28
|
UTSW |
6 |
58,243,039 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7961:Vmn1r28
|
UTSW |
6 |
58,242,178 (GRCm39) |
missense |
probably benign |
|
|
R8009:Vmn1r28
|
UTSW |
6 |
58,242,178 (GRCm39) |
missense |
probably benign |
|
|
R8156:Vmn1r28
|
UTSW |
6 |
58,242,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8167:Vmn1r28
|
UTSW |
6 |
58,243,052 (GRCm39) |
missense |
noncoding transcript |
|
|
R8879:Vmn1r28
|
UTSW |
6 |
58,242,669 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9639:Vmn1r28
|
UTSW |
6 |
58,242,996 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2013-10-07 |
Incidental Mutation