Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01365:Tead2'

75905

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tead2

Ensembl Gene

ENSMUSG00000030796

Gene Name

TEA domain family member 2

Synonyms

TEAD-2, TEF-4, Etdf

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01365

Quality Score

Status

Chromosome

Chromosomal Location

45215753-45233644 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 45217251 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 11 (D11E)

Ref Sequence

ENSEMBL: ENSMUSP00000103431 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033060] [ENSMUST00000097216] [ENSMUST00000107801] [ENSMUST00000209343] [ENSMUST00000209437] [ENSMUST00000209678] [ENSMUST00000210447] [ENSMUST00000211744]

Predicted Effect

probably damaging
Transcript: ENSMUST00000033060
AA Change: D11E

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000033060
Gene: ENSMUSG00000030796
AA Change: D11E

Domain	Start	End	E-Value	Type
TEA	36	107	4.84e-52	SMART
low complexity region	201	217	N/A	INTRINSIC
PDB:3L15\|B	218	445	1e-143	PDB

Predicted Effect

unknown
Transcript: ENSMUST00000097216
AA Change: D11E

SMART Domains

Protein: ENSMUSP00000103430
Gene: ENSMUSG00000030796
AA Change: D11E

Domain	Start	End	E-Value	Type
low complexity region	11	38	N/A	INTRINSIC
Pfam:TEA	40	402	1.8e-137	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000107801
AA Change: D11E

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000103431
Gene: ENSMUSG00000030796
AA Change: D11E

Domain	Start	End	E-Value	Type
TEA	36	107	4.84e-52	SMART
low complexity region	201	217	N/A	INTRINSIC
PDB:3L15\|B	218	445	1e-143	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000209343
AA Change: D11E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000209437
AA Change: D11E

PolyPhen 2 Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)

Predicted Effect

probably benign
Transcript: ENSMUST00000209678

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209708

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209818

Predicted Effect

probably benign
Transcript: ENSMUST00000210447
AA Change: D11E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210570

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211138

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211594

Predicted Effect

probably benign
Transcript: ENSMUST00000211744
AA Change: D11E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211778

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a functionally null allele of this gene exhibit no gross abnormalities and are fertile. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgre5	G	T	8: 83,723,889		probably null	Het
Agtr1a	A	G	13: 30,381,828	Y292C	probably damaging	Het
Btbd11	T	C	10: 85,633,816	V867A	possibly damaging	Het
CK137956	A	G	4: 127,951,342	S203P	probably benign	Het
Cnbd1	C	T	4: 18,860,576	G390D	probably damaging	Het
Cttnbp2nl	T	C	3: 105,005,030	T513A	probably damaging	Het
Dppa2	A	G	16: 48,313,913	K67R	possibly damaging	Het
Kif3a	A	G	11: 53,593,523	K486E	possibly damaging	Het
Lmnb2	G	T	10: 80,904,984	Q151K	probably benign	Het
Lmtk3	T	A	7: 45,790,907	L223Q	probably damaging	Het
Lrrk1	A	G	7: 66,287,701	I901T	probably damaging	Het
Macf1	T	C	4: 123,391,169	Y3624C	probably damaging	Het
Mios	T	A	6: 8,216,089	Y428*	probably null	Het
Myb	A	G	10: 21,152,502	I154T	probably benign	Het
Olfr294	T	C	7: 86,615,997	Y216C	probably damaging	Het
Parp9	C	T	16: 35,947,954	T168I	possibly damaging	Het
Pramel7	T	C	2: 87,491,413		probably benign	Het
Ptar1	T	A	19: 23,705,801	W140R	probably damaging	Het
Sec14l2	G	T	11: 4,098,317	D400E	probably benign	Het
Setd3	A	T	12: 108,157,906	Y175N	probably damaging	Het
Slc5a8	C	T	10: 88,892,097		probably benign	Het
Slc8a3	A	G	12: 81,315,376	V223A	probably damaging	Het
Srsf1	G	T	11: 88,049,181	R173L	possibly damaging	Het
Svep1	T	A	4: 58,100,878		probably null	Het
Trappc12	T	A	12: 28,747,402	I44F	probably damaging	Het
Ttll9	T	C	2: 153,000,134	Y303H	possibly damaging	Het
Vmn1r28	T	A	6: 58,265,191	N6K	possibly damaging	Het

Other mutations in Tead2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01887:Tead2	APN	7	45232310	missense	probably damaging	1.00
IGL02378:Tead2	APN	7	45218147	critical splice donor site	probably null
IGL02441:Tead2	APN	7	45217421	missense	probably damaging	1.00
IGL02716:Tead2	APN	7	45232296	nonsense	probably null
IGL02939:Tead2	APN	7	45220434	splice site	probably benign
IGL03302:Tead2	APN	7	45232899	missense	possibly damaging	0.86
R0325:Tead2	UTSW	7	45225755	missense	probably damaging	1.00
R0611:Tead2	UTSW	7	45217250	missense	probably damaging	0.99
R2571:Tead2	UTSW	7	45225770	missense	probably damaging	1.00
R3401:Tead2	UTSW	7	45223673	unclassified	probably benign
R3847:Tead2	UTSW	7	45232328	unclassified	probably null
R3849:Tead2	UTSW	7	45232328	unclassified	probably null
R3850:Tead2	UTSW	7	45232328	unclassified	probably null
R5729:Tead2	UTSW	7	45220742	unclassified	probably benign
R5932:Tead2	UTSW	7	45232899	missense	probably benign	0.00
R5956:Tead2	UTSW	7	45220714	unclassified	probably benign
R6208:Tead2	UTSW	7	45218102	missense	probably damaging	1.00
R6729:Tead2	UTSW	7	45217234	missense	probably benign
R7152:Tead2	UTSW	7	45220447	missense	possibly damaging	0.46

Posted On

2013-10-07