Incidental Mutation 'IGL01366:Vmn1r21'
ID75923
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r21
Ensembl Gene ENSMUSG00000115343
Gene Namevomeronasal 1 receptor 21
SynonymsV1rc28
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.183) question?
Stock #IGL01366
Quality Score
Status
Chromosome6
Chromosomal Location57842830-57850343 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 57843814 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 215 (I215T)
Ref Sequence ENSEMBL: ENSMUSP00000154295 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081186] [ENSMUST00000203310] [ENSMUST00000203488] [ENSMUST00000226191]
Predicted Effect probably benign
Transcript: ENSMUST00000081186
AA Change: I215T

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000079950
Gene: ENSMUSG00000058588
AA Change: I215T

DomainStartEndE-ValueType
Pfam:V1R 28 293 5.9e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203270
Predicted Effect probably benign
Transcript: ENSMUST00000203310
AA Change: I215T

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000145398
Gene: ENSMUSG00000115343
AA Change: I215T

DomainStartEndE-ValueType
Pfam:V1R 27 107 1.8e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203488
AA Change: I215T

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000144978
Gene: ENSMUSG00000115343
AA Change: I215T

DomainStartEndE-ValueType
Pfam:V1R 28 105 2e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226191
AA Change: I215T

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310002L09Rik A T 4: 73,950,700 probably benign Het
Adamts2 T C 11: 50,796,468 Y1041H probably damaging Het
Adck5 A C 15: 76,595,616 *568C probably null Het
AK157302 T A 13: 21,495,301 probably benign Het
Bmpr2 G T 1: 59,813,677 G56W probably damaging Het
Capn11 A C 17: 45,653,200 I146S probably damaging Het
Ccdc162 A T 10: 41,580,306 D1613E possibly damaging Het
Ccdc167 T C 17: 29,705,312 E50G probably damaging Het
Col5a2 G T 1: 45,391,888 P864Q possibly damaging Het
Col7a1 C T 9: 108,977,119 probably benign Het
Crebbp T A 16: 4,126,506 H556L probably damaging Het
Dcpp1 T A 17: 23,882,736 I153N possibly damaging Het
Dgke C T 11: 89,055,386 R196H probably benign Het
Efr3a T A 15: 65,851,150 I459K probably benign Het
Espl1 T A 15: 102,319,836 C1682S probably benign Het
Exosc3 C T 4: 45,317,747 R185H probably damaging Het
Fam160b2 G A 14: 70,585,373 R688C probably damaging Het
Fgd6 T C 10: 94,043,476 V64A possibly damaging Het
Gata3 A G 2: 9,877,465 L42P probably damaging Het
Ggta1 C A 2: 35,402,450 E282* probably null Het
Ghr T C 15: 3,320,187 D503G probably damaging Het
Gls C T 1: 52,168,399 G602D probably damaging Het
Gm2058 A G 7: 39,589,234 noncoding transcript Het
Grb7 T C 11: 98,452,274 probably benign Het
Ifngr1 A T 10: 19,609,600 H449L probably damaging Het
Ighg2b T G 12: 113,307,036 D158A possibly damaging Het
Nphs2 T C 1: 156,311,035 V83A probably benign Het
Parp6 T A 9: 59,636,713 M390K possibly damaging Het
Pask T C 1: 93,310,852 K1304E probably benign Het
Scai A G 2: 39,106,961 S274P probably benign Het
Sik2 A G 9: 50,907,463 S404P probably damaging Het
Slc7a8 A T 14: 54,781,188 I47N probably damaging Het
Tas2r113 A T 6: 132,893,797 I263F probably benign Het
Tdrd1 T A 19: 56,855,302 D737E probably benign Het
Trio T C 15: 27,732,868 T2976A possibly damaging Het
Ttc28 T C 5: 111,085,171 probably null Het
Other mutations in Vmn1r21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00329:Vmn1r21 APN 6 57844064 missense probably benign 0.05
IGL01660:Vmn1r21 APN 6 57844237 missense probably damaging 0.99
IGL02864:Vmn1r21 APN 6 57843676 missense probably benign 0.13
IGL02961:Vmn1r21 APN 6 57843989 missense probably benign 0.01
IGL03170:Vmn1r21 APN 6 57843862 missense probably damaging 0.99
PIT4453001:Vmn1r21 UTSW 6 57844322 missense probably benign 0.04
R1800:Vmn1r21 UTSW 6 57843814 missense probably benign 0.01
R1928:Vmn1r21 UTSW 6 57844092 nonsense probably null
R3407:Vmn1r21 UTSW 6 57843892 missense probably damaging 1.00
R5566:Vmn1r21 UTSW 6 57844094 missense probably benign 0.06
R6012:Vmn1r21 UTSW 6 57843906 missense probably damaging 1.00
R6293:Vmn1r21 UTSW 6 57844270 missense probably benign 0.19
R6473:Vmn1r21 UTSW 6 57843598 missense probably damaging 0.99
R7128:Vmn1r21 UTSW 6 57843951 missense probably damaging 0.97
R7489:Vmn1r21 UTSW 6 57843892 missense probably damaging 1.00
R7559:Vmn1r21 UTSW 6 57844242 missense probably damaging 0.99
R8002:Vmn1r21 UTSW 6 57844214 missense probably benign 0.00
R8218:Vmn1r21 UTSW 6 57843925 missense noncoding transcript
Z1176:Vmn1r21 UTSW 6 57843578 missense probably benign 0.01
Posted On2013-10-07