Incidental Mutation 'IGL01366:Ighg2b'
ID 75935
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ighg2b
Ensembl Gene ENSMUSG00000076613
Gene Name immunoglobulin heavy constant gamma 2B
Synonyms IgG2b, gamma2b
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # IGL01366
Quality Score
Status
Chromosome 12
Chromosomal Location 113267934-113271553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 113270656 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 158 (D158A)
Gene Model predicted gene model for transcript(s):
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000103418
AA Change: D158A

PolyPhen 2 Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000100214
Gene: ENSMUSG00000076613
AA Change: D158A

DomainStartEndE-ValueType
IGc1 22 92 6.9e-16 SMART
low complexity region 108 121 N/A INTRINSIC
IG_like 145 220 4.02e-2 SMART
IGc1 251 324 1.64e-31 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000192188
AA Change: D158A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310002L09Rik A T 4: 73,868,937 (GRCm39) probably benign Het
Adamts2 T C 11: 50,687,295 (GRCm39) Y1041H probably damaging Het
Adck5 A C 15: 76,479,816 (GRCm39) *568C probably null Het
AK157302 T A 13: 21,679,471 (GRCm39) probably benign Het
Bmpr2 G T 1: 59,852,836 (GRCm39) G56W probably damaging Het
Capn11 A C 17: 45,964,126 (GRCm39) I146S probably damaging Het
Ccdc162 A T 10: 41,456,302 (GRCm39) D1613E possibly damaging Het
Ccdc167 T C 17: 29,924,286 (GRCm39) E50G probably damaging Het
Col5a2 G T 1: 45,431,048 (GRCm39) P864Q possibly damaging Het
Col7a1 C T 9: 108,806,187 (GRCm39) probably benign Het
Crebbp T A 16: 3,944,370 (GRCm39) H556L probably damaging Het
Dcpp1 T A 17: 24,101,710 (GRCm39) I153N possibly damaging Het
Dgke C T 11: 88,946,212 (GRCm39) R196H probably benign Het
Efr3a T A 15: 65,722,999 (GRCm39) I459K probably benign Het
Espl1 T A 15: 102,228,271 (GRCm39) C1682S probably benign Het
Exosc3 C T 4: 45,317,747 (GRCm39) R185H probably damaging Het
Fgd6 T C 10: 93,879,338 (GRCm39) V64A possibly damaging Het
Fhip2b G A 14: 70,822,813 (GRCm39) R688C probably damaging Het
Gata3 A G 2: 9,882,276 (GRCm39) L42P probably damaging Het
Ggta1 C A 2: 35,292,462 (GRCm39) E282* probably null Het
Ghr T C 15: 3,349,669 (GRCm39) D503G probably damaging Het
Gls C T 1: 52,207,558 (GRCm39) G602D probably damaging Het
Gm2058 A G 7: 39,238,658 (GRCm39) noncoding transcript Het
Grb7 T C 11: 98,343,100 (GRCm39) probably benign Het
Ifngr1 A T 10: 19,485,348 (GRCm39) H449L probably damaging Het
Nphs2 T C 1: 156,138,605 (GRCm39) V83A probably benign Het
Parp6 T A 9: 59,543,996 (GRCm39) M390K possibly damaging Het
Pask T C 1: 93,238,574 (GRCm39) K1304E probably benign Het
Scai A G 2: 38,996,973 (GRCm39) S274P probably benign Het
Sik2 A G 9: 50,818,763 (GRCm39) S404P probably damaging Het
Slc7a8 A T 14: 55,018,645 (GRCm39) I47N probably damaging Het
Tas2r113 A T 6: 132,870,760 (GRCm39) I263F probably benign Het
Tdrd1 T A 19: 56,843,734 (GRCm39) D737E probably benign Het
Trio T C 15: 27,732,954 (GRCm39) T2976A possibly damaging Het
Ttc28 T C 5: 111,233,037 (GRCm39) probably null Het
Vmn1r21 A G 6: 57,820,799 (GRCm39) I215T probably benign Het
Other mutations in Ighg2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01837:Ighg2b APN 12 113,270,065 (GRCm39) missense unknown
IGL01973:Ighg2b APN 12 113,271,305 (GRCm39) missense unknown
IGL01998:Ighg2b APN 12 113,270,709 (GRCm39) missense unknown
IGL02147:Ighg2b APN 12 113,270,011 (GRCm39) makesense probably null
IGL02183:Ighg2b APN 12 113,271,449 (GRCm39) missense unknown
IGL03089:Ighg2b APN 12 113,270,298 (GRCm39) missense probably damaging 1.00
PIT4453001:Ighg2b UTSW 12 113,270,492 (GRCm39) missense unknown
R4199:Ighg2b UTSW 12 113,270,907 (GRCm39) missense probably damaging 0.96
R4459:Ighg2b UTSW 12 113,270,578 (GRCm39) missense unknown
R4577:Ighg2b UTSW 12 113,270,512 (GRCm39) missense unknown
R4589:Ighg2b UTSW 12 113,270,104 (GRCm39) missense unknown
R4807:Ighg2b UTSW 12 113,267,965 (GRCm39) unclassified probably benign
R4822:Ighg2b UTSW 12 113,270,011 (GRCm39) makesense probably null
R5424:Ighg2b UTSW 12 113,271,550 (GRCm39) missense unknown
R5641:Ighg2b UTSW 12 113,270,767 (GRCm39) missense unknown
R6297:Ighg2b UTSW 12 113,270,512 (GRCm39) missense unknown
R6701:Ighg2b UTSW 12 113,270,699 (GRCm39) missense unknown
R6703:Ighg2b UTSW 12 113,268,653 (GRCm39) unclassified probably benign
R6880:Ighg2b UTSW 12 113,270,726 (GRCm39) missense
R7342:Ighg2b UTSW 12 113,270,050 (GRCm39) missense
R7505:Ighg2b UTSW 12 113,268,600 (GRCm39) missense
R7908:Ighg2b UTSW 12 113,270,074 (GRCm39) missense
R8543:Ighg2b UTSW 12 113,270,552 (GRCm39) missense probably damaging 1.00
R8951:Ighg2b UTSW 12 113,270,926 (GRCm39) missense probably benign
R9237:Ighg2b UTSW 12 113,270,217 (GRCm39) missense
R9539:Ighg2b UTSW 12 113,270,498 (GRCm39) missense
R9789:Ighg2b UTSW 12 113,270,304 (GRCm39) missense
Posted On 2013-10-07