Incidental Mutation 'IGL01367:Denr'
ID 75971
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Denr
Ensembl Gene ENSMUSG00000023106
Gene Name density-regulated protein
Synonyms 1500003K04Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01367
Quality Score
Status
Chromosome 5
Chromosomal Location 124045309-124066705 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 124046182 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 4 (D4G)
Ref Sequence ENSEMBL: ENSMUSP00000126174 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023869] [ENSMUST00000166233]
AlphaFold Q9CQJ6
Predicted Effect probably benign
Transcript: ENSMUST00000023869
AA Change: D4G

PolyPhen 2 Score 0.187 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000023869
Gene: ENSMUSG00000023106
AA Change: D4G

DomainStartEndE-ValueType
Pfam:SUI1 111 184 3.1e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166233
AA Change: D4G

PolyPhen 2 Score 0.187 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000126174
Gene: ENSMUSG00000023106
AA Change: D4G

DomainStartEndE-ValueType
Pfam:SUI1 108 183 4e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168899
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171639
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198321
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik A G 11: 30,404,843 (GRCm39) V20A possibly damaging Het
Alk T C 17: 72,207,781 (GRCm39) I985V probably damaging Het
Anapc2 A C 2: 25,164,794 (GRCm39) R59S possibly damaging Het
Ankhd1 T A 18: 36,711,696 (GRCm39) D165E probably benign Het
Asb8 A T 15: 98,034,054 (GRCm39) V167D probably damaging Het
Atp5pf A G 16: 84,625,360 (GRCm39) M81T probably benign Het
Bcl7b A G 5: 135,208,950 (GRCm39) T138A probably damaging Het
Cdh23 A G 10: 60,146,566 (GRCm39) L2869P probably damaging Het
Chl1 T C 6: 103,706,186 (GRCm39) S1174P probably benign Het
Clec2g T C 6: 128,925,699 (GRCm39) I36T unknown Het
Dnajc10 T C 2: 80,155,096 (GRCm39) probably benign Het
Egf C T 3: 129,496,104 (GRCm39) probably null Het
Galnt10 A C 11: 57,616,409 (GRCm39) Y108S probably damaging Het
Gls C T 1: 52,207,558 (GRCm39) G602D probably damaging Het
Grb10 G T 11: 11,895,599 (GRCm39) Q242K probably damaging Het
Hspg2 A T 4: 137,265,800 (GRCm39) Y1837F probably damaging Het
Ikzf1 G T 11: 11,698,358 (GRCm39) A70S probably benign Het
Il17ra T C 6: 120,458,426 (GRCm39) Y526H probably damaging Het
Il34 A T 8: 111,469,375 (GRCm39) I186N possibly damaging Het
Iqca1 G A 1: 89,998,350 (GRCm39) probably benign Het
Kntc1 A G 5: 123,896,546 (GRCm39) Y136C probably damaging Het
Man2b2 A T 5: 36,971,681 (GRCm39) Y257* probably null Het
Map3k19 A G 1: 127,752,088 (GRCm39) F421S possibly damaging Het
Melk A G 4: 44,332,907 (GRCm39) T288A possibly damaging Het
Mpp2 T C 11: 101,954,135 (GRCm39) E187G probably damaging Het
Mtf2 A G 5: 108,252,323 (GRCm39) T394A probably benign Het
Neil2 A G 14: 63,429,177 (GRCm39) S39P probably damaging Het
Or4e5 T A 14: 52,727,624 (GRCm39) I266F probably benign Het
Pcdh7 A G 5: 58,286,566 (GRCm39) E1214G possibly damaging Het
Pcdhb17 G T 18: 37,620,548 (GRCm39) Q779H probably benign Het
Pik3c2b A G 1: 133,033,726 (GRCm39) I1577V probably benign Het
Pkp3 C T 7: 140,663,989 (GRCm39) P389S probably damaging Het
Ppp4r2 T A 6: 100,841,706 (GRCm39) Y92* probably null Het
Rnf13 T C 3: 57,714,508 (GRCm39) I189T probably benign Het
Serpinf2 T C 11: 75,328,871 (GRCm39) D53G probably benign Het
Slc47a2 T A 11: 61,220,607 (GRCm39) T184S probably benign Het
Sned1 T C 1: 93,210,936 (GRCm39) I1008T probably benign Het
Sorcs3 A T 19: 48,784,814 (GRCm39) E1079V probably damaging Het
Trappc8 G A 18: 20,999,176 (GRCm39) S318L probably benign Het
Trappc9 A G 15: 72,462,002 (GRCm39) S909P probably benign Het
Ttn G A 2: 76,560,483 (GRCm39) T29306I probably damaging Het
Twnk G A 19: 45,000,090 (GRCm39) R602Q possibly damaging Het
Vmn2r15 A T 5: 109,441,075 (GRCm39) I261K probably damaging Het
Vmn2r77 G A 7: 86,461,124 (GRCm39) A817T probably damaging Het
Other mutations in Denr
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0007:Denr UTSW 5 124,062,877 (GRCm39) missense probably damaging 1.00
R0007:Denr UTSW 5 124,062,877 (GRCm39) missense probably damaging 1.00
R0025:Denr UTSW 5 124,065,298 (GRCm39) unclassified probably benign
R0079:Denr UTSW 5 124,062,908 (GRCm39) missense probably damaging 1.00
R0567:Denr UTSW 5 124,046,221 (GRCm39) missense probably benign 0.01
R1818:Denr UTSW 5 124,055,283 (GRCm39) missense probably benign 0.00
R5125:Denr UTSW 5 124,065,144 (GRCm39) missense probably damaging 1.00
R6930:Denr UTSW 5 124,046,250 (GRCm39) missense probably benign 0.02
R7657:Denr UTSW 5 124,046,263 (GRCm39) missense probably damaging 0.96
R8379:Denr UTSW 5 124,065,124 (GRCm39) missense possibly damaging 0.59
R8970:Denr UTSW 5 124,055,279 (GRCm39) missense probably damaging 1.00
R9680:Denr UTSW 5 124,065,117 (GRCm39) missense possibly damaging 0.81
Posted On 2013-10-07