Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01368:Olfr952'

76004

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr952

Ensembl Gene

ENSMUSG00000058856

Gene Name

olfactory receptor 952

Synonyms

MOR171-21, GA_x6K02T2PVTD-33124064-33123120

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL01368

Quality Score

Status

Chromosome

Chromosomal Location

39426093-39427148 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 39426180 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 297 (V297D)

Ref Sequence

ENSEMBL: ENSMUSP00000073558 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073895]

Predicted Effect

probably damaging
Transcript: ENSMUST00000073895
AA Change: V297D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000073558
Gene: ENSMUSG00000058856
AA Change: V297D

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	8.5e-42	PFAM
Pfam:7tm_1	41	294	3.2e-18	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acod1	T	A	14: 103,051,334	D93E	probably damaging	Het
Adam22	T	C	5: 8,127,411	Y566C	probably damaging	Het
Atp8b3	G	A	10: 80,534,229		probably benign	Het
Babam1	T	A	8: 71,398,406	D104E	probably damaging	Het
Bcl2a1a	T	A	9: 88,957,447	W133R	probably damaging	Het
Ckm	C	T	7: 19,416,787	Q184*	probably null	Het
Clk4	T	A	11: 51,281,172	Y246*	probably null	Het
Cyp3a57	T	C	5: 145,369,068	S121P	probably damaging	Het
Gm5039	C	T	12: 88,321,088	D132N	unknown	Het
Gm5771	A	G	6: 41,396,686	D161G	possibly damaging	Het
Gm8011	T	C	14: 42,465,874		probably benign	Het
Gpr153	T	C	4: 152,282,994	F434S	probably benign	Het
Gpr158	G	T	2: 21,827,098	W1003L	probably damaging	Het
Ighv5-9-1	T	C	12: 113,736,390	E34G	probably damaging	Het
Igkv16-104	G	T	6: 68,425,610	R2S	possibly damaging	Het
Map3k3	T	C	11: 106,150,389	F395L	probably benign	Het
Myof	T	A	19: 37,936,457	T1161S	probably damaging	Het
Nlrp9a	T	C	7: 26,557,874	S217P	probably damaging	Het
Nol9	T	A	4: 152,058,391	N687K	probably benign	Het
Olfr287	T	C	15: 98,207,500	I295V	probably damaging	Het
Olfr697	T	C	7: 106,741,622	E104G	probably benign	Het
Olfr748	T	C	14: 50,710,993	V221A	possibly damaging	Het
Rrh	T	C	3: 129,808,969	D229G	probably benign	Het
Sclt1	T	C	3: 41,711,175	T153A	probably damaging	Het
Slc41a1	G	A	1: 131,839,124	V127I	probably damaging	Het
Smarca2	C	T	19: 26,774,294	S214L	possibly damaging	Het
Tmem63a	T	C	1: 180,970,232	V616A	possibly damaging	Het
Ubr1	A	G	2: 120,941,131		probably benign	Het
Vmn1r228	A	G	17: 20,776,512	L248P	probably benign	Het
Zdhhc16	T	A	19: 41,941,506		probably null	Het

Other mutations in Olfr952

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00976:Olfr952	APN	9	39426657	missense	probably benign	0.02
IGL01866:Olfr952	APN	9	39426729	missense	probably damaging	0.99
IGL01939:Olfr952	APN	9	39426338	missense	probably damaging	1.00
IGL03048:Olfr952	UTSW	9	39426769	missense	probably benign	0.00
R0069:Olfr952	UTSW	9	39426892	missense	probably damaging	0.98
R1460:Olfr952	UTSW	9	39426207	missense	probably benign	0.43
R1478:Olfr952	UTSW	9	39426592	missense	possibly damaging	0.91
R1737:Olfr952	UTSW	9	39426958	missense	probably damaging	0.99
R2112:Olfr952	UTSW	9	39426670	missense	probably benign	0.26
R2169:Olfr952	UTSW	9	39426358	missense	possibly damaging	0.95
R2225:Olfr952	UTSW	9	39426619	missense	probably benign	0.00
R3731:Olfr952	UTSW	9	39427069	start codon destroyed	probably benign	0.23
R3777:Olfr952	UTSW	9	39426605	missense	possibly damaging	0.75
R3802:Olfr952	UTSW	9	39426286	missense	probably damaging	1.00
R4600:Olfr952	UTSW	9	39426435	missense	probably benign	0.27
R4887:Olfr952	UTSW	9	39426235	missense	possibly damaging	0.80
R5215:Olfr952	UTSW	9	39426623	nonsense	probably null
R5813:Olfr952	UTSW	9	39426736	missense	probably damaging	1.00
R6140:Olfr952	UTSW	9	39426247	missense	possibly damaging	0.91
R6180:Olfr952	UTSW	9	39426712	missense	probably damaging	1.00
R6383:Olfr952	UTSW	9	39426234	missense	probably damaging	1.00
R6416:Olfr952	UTSW	9	39426891	missense	probably damaging	0.98
R6808:Olfr952	UTSW	9	39426540	missense	probably damaging	0.99
R7099:Olfr952	UTSW	9	39426303	missense	probably benign	0.01
R7826:Olfr952	UTSW	9	39426127	makesense	probably null
R8309:Olfr952	UTSW	9	39426670	missense	probably benign	0.40
R8870:Olfr952	UTSW	9	39426252	missense	probably damaging	0.97
R8879:Olfr952	UTSW	9	39426219	missense	possibly damaging	0.86

Posted On

2013-10-07