Incidental Mutation 'IGL01368:Vmn1r228'
ID76020
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r228
Ensembl Gene ENSMUSG00000060245
Gene Namevomeronasal 1 receptor 228
SynonymsV1re3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #IGL01368
Quality Score
Status
Chromosome17
Chromosomal Location20776059-20777501 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 20776512 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 248 (L248P)
Ref Sequence ENSEMBL: ENSMUSP00000072243 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072410]
Predicted Effect probably benign
Transcript: ENSMUST00000072410
AA Change: L248P

PolyPhen 2 Score 0.071 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000072243
Gene: ENSMUSG00000060245
AA Change: L248P

DomainStartEndE-ValueType
Pfam:TAS2R 32 317 2.6e-11 PFAM
Pfam:7tm_1 53 316 2.6e-9 PFAM
Pfam:V1R 63 321 1.3e-26 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acod1 T A 14: 103,051,334 D93E probably damaging Het
Adam22 T C 5: 8,127,411 Y566C probably damaging Het
Atp8b3 G A 10: 80,534,229 probably benign Het
Babam1 T A 8: 71,398,406 D104E probably damaging Het
Bcl2a1a T A 9: 88,957,447 W133R probably damaging Het
Ckm C T 7: 19,416,787 Q184* probably null Het
Clk4 T A 11: 51,281,172 Y246* probably null Het
Cyp3a57 T C 5: 145,369,068 S121P probably damaging Het
Gm5039 C T 12: 88,321,088 D132N unknown Het
Gm5771 A G 6: 41,396,686 D161G possibly damaging Het
Gm8011 T C 14: 42,465,874 probably benign Het
Gpr153 T C 4: 152,282,994 F434S probably benign Het
Gpr158 G T 2: 21,827,098 W1003L probably damaging Het
Ighv5-9-1 T C 12: 113,736,390 E34G probably damaging Het
Igkv16-104 G T 6: 68,425,610 R2S possibly damaging Het
Map3k3 T C 11: 106,150,389 F395L probably benign Het
Myof T A 19: 37,936,457 T1161S probably damaging Het
Nlrp9a T C 7: 26,557,874 S217P probably damaging Het
Nol9 T A 4: 152,058,391 N687K probably benign Het
Olfr287 T C 15: 98,207,500 I295V probably damaging Het
Olfr697 T C 7: 106,741,622 E104G probably benign Het
Olfr748 T C 14: 50,710,993 V221A possibly damaging Het
Olfr952 A T 9: 39,426,180 V297D probably damaging Het
Rrh T C 3: 129,808,969 D229G probably benign Het
Sclt1 T C 3: 41,711,175 T153A probably damaging Het
Slc41a1 G A 1: 131,839,124 V127I probably damaging Het
Smarca2 C T 19: 26,774,294 S214L possibly damaging Het
Tmem63a T C 1: 180,970,232 V616A possibly damaging Het
Ubr1 A G 2: 120,941,131 probably benign Het
Zdhhc16 T A 19: 41,941,506 probably null Het
Other mutations in Vmn1r228
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03275:Vmn1r228 APN 17 20776842 missense probably damaging 1.00
PIT4498001:Vmn1r228 UTSW 17 20776510 missense probably benign 0.00
R0097:Vmn1r228 UTSW 17 20776363 missense probably benign 0.05
R0097:Vmn1r228 UTSW 17 20776363 missense probably benign 0.05
R0270:Vmn1r228 UTSW 17 20776596 missense possibly damaging 0.60
R0279:Vmn1r228 UTSW 17 20776375 missense probably benign 0.02
R1544:Vmn1r228 UTSW 17 20777023 missense probably benign 0.00
R1695:Vmn1r228 UTSW 17 20776298 missense possibly damaging 0.49
R2086:Vmn1r228 UTSW 17 20777193 missense possibly damaging 0.71
R2275:Vmn1r228 UTSW 17 20776545 missense probably damaging 1.00
R2965:Vmn1r228 UTSW 17 20776347 missense probably damaging 0.99
R4425:Vmn1r228 UTSW 17 20776599 missense probably damaging 1.00
R4447:Vmn1r228 UTSW 17 20777107 missense probably damaging 0.96
R5031:Vmn1r228 UTSW 17 20776681 nonsense probably null
R6345:Vmn1r228 UTSW 17 20776882 missense probably damaging 1.00
R7064:Vmn1r228 UTSW 17 20777023 missense probably benign 0.00
R7880:Vmn1r228 UTSW 17 20776410 missense probably damaging 1.00
R8000:Vmn1r228 UTSW 17 20776965 missense possibly damaging 0.88
R8290:Vmn1r228 UTSW 17 20776462 missense probably benign 0.09
X0018:Vmn1r228 UTSW 17 20776701 missense probably benign 0.08
Posted On2013-10-07