Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01370:Or1p1c'

76088

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or1p1c

Ensembl Gene

ENSMUSG00000070375

Gene Name

olfactory receptor family 1 subfamily P member 1C

Synonyms

Olfr406, MOR133-1, Olfr406-ps, GA_x6K02T2P1NL-4415162-4416133

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01370

Quality Score

Status

Chromosome

Chromosomal Location

74160217-74161188 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 74160325 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 37 (V37I)

Ref Sequence

ENSEMBL: ENSMUSP00000148929 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000133561] [ENSMUST00000214303] [ENSMUST00000217016]

AlphaFold

Q7TRX0

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127098

Predicted Effect

probably benign
Transcript: ENSMUST00000133561
AA Change: V37I

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000125963
Gene: ENSMUSG00000070375
AA Change: V37I

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	310	3.5e-56	PFAM
Pfam:7tm_1	41	292	3e-27	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214303
AA Change: V37I

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

Predicted Effect

probably benign
Transcript: ENSMUST00000217016
AA Change: V37I

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adck1	A	T	12: 88,423,503 (GRCm39)		probably benign	Het
Add1	C	T	5: 34,787,859 (GRCm39)	T210I	probably damaging	Het
Ajm1	T	C	2: 25,468,969 (GRCm39)	E314G	possibly damaging	Het
Alpk2	A	T	18: 65,483,662 (GRCm39)	D115E	possibly damaging	Het
Ankrd36	C	T	11: 5,534,019 (GRCm39)	T290I	probably benign	Het
Bltp1	T	A	3: 37,001,904 (GRCm39)	I1283N	probably benign	Het
Castor2	T	C	5: 134,167,111 (GRCm39)	V323A	probably benign	Het
Ccnt2	T	C	1: 127,731,250 (GRCm39)	F709S	possibly damaging	Het
Erc1	T	C	6: 119,801,426 (GRCm39)	E197G	probably damaging	Het
Ftsj3	G	T	11: 106,143,145 (GRCm39)	R390S	possibly damaging	Het
Gabrb3	G	A	7: 57,466,226 (GRCm39)	A347T	probably benign	Het
Gde1	A	G	7: 118,288,383 (GRCm39)		probably benign	Het
Jhy	A	T	9: 40,828,438 (GRCm39)	N489K	probably benign	Het
Kiss1r	A	G	10: 79,754,658 (GRCm39)	T51A	probably benign	Het
Lama5	T	C	2: 179,839,193 (GRCm39)	S772G	possibly damaging	Het
Lamb2	G	T	9: 108,364,932 (GRCm39)		probably null	Het
Loxl3	A	G	6: 83,026,468 (GRCm39)	T475A	probably damaging	Het
Lpl	A	T	8: 69,340,220 (GRCm39)	S72C	possibly damaging	Het
Lrrc74a	A	T	12: 86,801,204 (GRCm39)	I352F	probably damaging	Het
Mcoln2	T	C	3: 145,887,585 (GRCm39)	I334T	possibly damaging	Het
Mettl8	T	G	2: 70,812,383 (GRCm39)	D49A	probably damaging	Het
Ms4a3	T	A	19: 11,610,245 (GRCm39)	T106S	probably benign	Het
Obscn	T	A	11: 58,886,389 (GRCm39)		probably null	Het
Or14j2	T	C	17: 37,885,412 (GRCm39)	I301V	probably null	Het
Or1o11	C	A	17: 37,756,605 (GRCm39)	H64Q	probably benign	Het
Or4n4	G	T	14: 50,519,689 (GRCm39)	T7K	probably damaging	Het
Or5b107	A	T	19: 13,142,663 (GRCm39)	Y95F	possibly damaging	Het
Pcnx2	T	C	8: 126,528,222 (GRCm39)	K1333E	probably damaging	Het
Pias3	T	C	3: 96,610,891 (GRCm39)	F364L	probably damaging	Het
Piezo2	T	A	18: 63,155,531 (GRCm39)	I2438F	probably damaging	Het
Plcb3	A	C	19: 6,940,192 (GRCm39)	V465G	probably damaging	Het
Plekho2	G	T	9: 65,465,912 (GRCm39)	H159N	probably damaging	Het
Polr2e	A	G	10: 79,872,681 (GRCm39)		probably benign	Het
Rab6b	G	T	9: 103,041,094 (GRCm39)	V163L	probably benign	Het
Rabep1	A	G	11: 70,816,607 (GRCm39)	M597V	probably benign	Het
Rbm15	A	G	3: 107,238,326 (GRCm39)	S691P	probably damaging	Het
Sec24b	G	A	3: 129,801,253 (GRCm39)		probably benign	Het
Slc6a18	A	G	13: 73,815,150 (GRCm39)	I386T	probably damaging	Het
Stxbp3	A	C	3: 108,704,741 (GRCm39)	Y497*	probably null	Het
Styk1	T	C	6: 131,278,615 (GRCm39)	K353R	probably damaging	Het
Tbc1d10b	A	T	7: 126,798,253 (GRCm39)	H629Q	probably damaging	Het
Tbc1d5	T	A	17: 51,273,755 (GRCm39)	I119F	probably benign	Het
Tcp11l1	G	T	2: 104,536,831 (GRCm39)	D11E	probably benign	Het
Tfap2d	A	G	1: 19,175,009 (GRCm39)	Y154C	probably damaging	Het
Tgm5	T	C	2: 120,884,018 (GRCm39)	N325S	probably benign	Het
Thbs2	T	C	17: 14,910,327 (GRCm39)	K91E	possibly damaging	Het
Vmn2r26	T	A	6: 124,038,715 (GRCm39)	F763L	probably benign	Het
Washc4	A	G	10: 83,394,694 (GRCm39)	E308G	probably damaging	Het
Xpot	C	A	10: 121,440,399 (GRCm39)	A611S	probably benign	Het

Other mutations in Or1p1c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01480:Or1p1c	APN	11	74,160,427 (GRCm39)	missense	possibly damaging	0.64
IGL02138:Or1p1c	APN	11	74,160,544 (GRCm39)	missense	probably benign	0.01
IGL02986:Or1p1c	APN	11	74,160,928 (GRCm39)	missense	possibly damaging	0.82
R0018:Or1p1c	UTSW	11	74,160,934 (GRCm39)	missense	probably benign	0.39
R1822:Or1p1c	UTSW	11	74,161,066 (GRCm39)	missense	probably benign	0.11
R1823:Or1p1c	UTSW	11	74,161,043 (GRCm39)	missense	probably damaging	1.00
R1956:Or1p1c	UTSW	11	74,160,670 (GRCm39)	missense	probably damaging	1.00
R2017:Or1p1c	UTSW	11	74,161,159 (GRCm39)	missense	probably benign
R2879:Or1p1c	UTSW	11	74,161,049 (GRCm39)	missense	probably damaging	1.00
R3854:Or1p1c	UTSW	11	74,161,105 (GRCm39)	nonsense	probably null
R4750:Or1p1c	UTSW	11	74,160,246 (GRCm39)	missense	probably benign	0.00
R6076:Or1p1c	UTSW	11	74,161,088 (GRCm39)	missense	probably damaging	1.00
R6257:Or1p1c	UTSW	11	74,160,833 (GRCm39)	missense	probably damaging	1.00
R6431:Or1p1c	UTSW	11	74,160,235 (GRCm39)	missense	possibly damaging	0.95
R7032:Or1p1c	UTSW	11	74,160,428 (GRCm39)	missense	possibly damaging	0.95
R7216:Or1p1c	UTSW	11	74,160,550 (GRCm39)	missense	probably damaging	1.00
R7429:Or1p1c	UTSW	11	74,160,579 (GRCm39)	missense	probably damaging	1.00
R8144:Or1p1c	UTSW	11	74,160,384 (GRCm39)	missense	probably damaging	0.98
R8161:Or1p1c	UTSW	11	74,160,544 (GRCm39)	missense	probably benign	0.01
R8847:Or1p1c	UTSW	11	74,160,443 (GRCm39)	missense	probably damaging	1.00
R8872:Or1p1c	UTSW	11	74,160,120 (GRCm39)	splice site	probably benign
R8977:Or1p1c	UTSW	11	74,160,304 (GRCm39)	missense	probably benign	0.02
R9049:Or1p1c	UTSW	11	74,161,115 (GRCm39)	missense	possibly damaging	0.80
R9336:Or1p1c	UTSW	11	74,160,743 (GRCm39)	missense	probably damaging	0.98
R9596:Or1p1c	UTSW	11	74,160,289 (GRCm39)	missense	probably benign
R9771:Or1p1c	UTSW	11	74,160,635 (GRCm39)	missense	probably benign	0.05

Posted On

2013-10-07