Incidental Mutation 'IGL01371:Olfr1459'
ID76133
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1459
Ensembl Gene ENSMUSG00000057503
Gene Nameolfactory receptor 1459
SynonymsMOR202-17, GA_x6K02T2RE5P-3473421-3472498
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #IGL01371
Quality Score
Status
Chromosome19
Chromosomal Location13138021-13149549 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 13145828 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 277 (T277I)
Ref Sequence ENSEMBL: ENSMUSP00000150886 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078299] [ENSMUST00000213493]
Predicted Effect possibly damaging
Transcript: ENSMUST00000078299
AA Change: T277I

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000077414
Gene: ENSMUSG00000057503
AA Change: T277I

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 8e-50 PFAM
Pfam:7tm_1 39 288 1.5e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213493
AA Change: T277I

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215405
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1300017J02Rik T C 9: 103,254,776 E504G possibly damaging Het
Abcc9 C T 6: 142,656,614 R691Q probably benign Het
AI314180 A G 4: 58,809,718 L1583P probably damaging Het
Ambra1 G T 2: 91,825,286 G700W probably damaging Het
Atp6v1c1 A G 15: 38,682,960 I198V probably benign Het
Bptf T C 11: 107,055,907 N2353S probably benign Het
Cd84 A T 1: 171,886,370 T312S probably benign Het
Chl1 G T 6: 103,715,364 C1064F probably damaging Het
Clca4a T C 3: 144,960,672 D473G probably damaging Het
Dsp A G 13: 38,193,617 R1793G probably benign Het
Dync1h1 A G 12: 110,638,851 N2374S probably benign Het
Gm43191 A T 3: 116,645,463 I130N probably damaging Het
Gm5134 T G 10: 76,004,747 L475R probably damaging Het
Grm1 A G 10: 10,720,039 V615A probably benign Het
Loxl1 T A 9: 58,294,422 Q462L possibly damaging Het
Nwd1 T C 8: 72,675,115 W755R probably damaging Het
Olfr1102 A T 2: 87,002,923 K318M probably benign Het
Olfr1408 A G 1: 173,130,531 S229P possibly damaging Het
Otud4 T C 8: 79,673,761 F1034L probably damaging Het
Pakap C A 4: 57,856,325 D551E probably benign Het
Panx3 T G 9: 37,661,475 T260P probably benign Het
Ppfia4 A T 1: 134,328,086 S194T probably benign Het
Rnf135 T A 11: 80,189,255 I124N probably benign Het
Rpf1 T C 3: 146,507,547 N283S probably damaging Het
Smg5 A G 3: 88,359,644 probably benign Het
Stard9 A G 2: 120,701,368 E2702G probably benign Het
Tbk1 A T 10: 121,559,871 M439K probably benign Het
Tmem235 T C 11: 117,862,306 L85P possibly damaging Het
Trhde A T 10: 114,588,500 V460E possibly damaging Het
Ttn T C 2: 76,790,264 probably benign Het
Vmn1r83 A G 7: 12,321,233 F299S probably benign Het
Other mutations in Olfr1459
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01618:Olfr1459 APN 19 13146250 missense probably benign 0.00
IGL01800:Olfr1459 APN 19 13146629 missense probably damaging 1.00
IGL02224:Olfr1459 APN 19 13145756 missense probably damaging 1.00
PIT4651001:Olfr1459 UTSW 19 13146627 missense probably benign 0.02
R0617:Olfr1459 UTSW 19 13146363 missense probably benign 0.28
R2041:Olfr1459 UTSW 19 13146677 start gained probably benign
R2878:Olfr1459 UTSW 19 13146407 missense probably benign 0.38
R3742:Olfr1459 UTSW 19 13145894 missense probably damaging 0.98
R4905:Olfr1459 UTSW 19 13146177 missense probably benign 0.07
R4914:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4915:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4916:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4917:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4918:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R5367:Olfr1459 UTSW 19 13146501 missense probably damaging 0.98
R6242:Olfr1459 UTSW 19 13146086 missense probably benign 0.05
R6632:Olfr1459 UTSW 19 13146188 missense probably benign 0.02
R6893:Olfr1459 UTSW 19 13145742 missense probably benign 0.00
Posted On2013-10-07