Incidental Mutation 'IGL01371:Olfr1408'
ID76138
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1408
Ensembl Gene ENSMUSG00000062527
Gene Nameolfactory receptor 1408
SynonymsMOR267-4, GA_x6K02T2R7CC-715776-716708
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.079) question?
Stock #IGL01371
Quality Score
Status
Chromosome1
Chromosomal Location173128049-173137374 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 173130531 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 229 (S229P)
Ref Sequence ENSEMBL: ENSMUSP00000143864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073663] [ENSMUST00000200689]
Predicted Effect possibly damaging
Transcript: ENSMUST00000073663
AA Change: S229P

PolyPhen 2 Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000073345
Gene: ENSMUSG00000062527
AA Change: S229P

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.5e-55 PFAM
Pfam:7tm_1 41 289 9.4e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000200689
AA Change: S229P

PolyPhen 2 Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000143864
Gene: ENSMUSG00000062527
AA Change: S229P

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.5e-55 PFAM
Pfam:7tm_1 41 289 9.4e-19 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1300017J02Rik T C 9: 103,254,776 E504G possibly damaging Het
Abcc9 C T 6: 142,656,614 R691Q probably benign Het
AI314180 A G 4: 58,809,718 L1583P probably damaging Het
Ambra1 G T 2: 91,825,286 G700W probably damaging Het
Atp6v1c1 A G 15: 38,682,960 I198V probably benign Het
Bptf T C 11: 107,055,907 N2353S probably benign Het
Cd84 A T 1: 171,886,370 T312S probably benign Het
Chl1 G T 6: 103,715,364 C1064F probably damaging Het
Clca4a T C 3: 144,960,672 D473G probably damaging Het
Dsp A G 13: 38,193,617 R1793G probably benign Het
Dync1h1 A G 12: 110,638,851 N2374S probably benign Het
Gm43191 A T 3: 116,645,463 I130N probably damaging Het
Gm5134 T G 10: 76,004,747 L475R probably damaging Het
Grm1 A G 10: 10,720,039 V615A probably benign Het
Loxl1 T A 9: 58,294,422 Q462L possibly damaging Het
Nwd1 T C 8: 72,675,115 W755R probably damaging Het
Olfr1102 A T 2: 87,002,923 K318M probably benign Het
Olfr1459 G A 19: 13,145,828 T277I possibly damaging Het
Otud4 T C 8: 79,673,761 F1034L probably damaging Het
Pakap C A 4: 57,856,325 D551E probably benign Het
Panx3 T G 9: 37,661,475 T260P probably benign Het
Ppfia4 A T 1: 134,328,086 S194T probably benign Het
Rnf135 T A 11: 80,189,255 I124N probably benign Het
Rpf1 T C 3: 146,507,547 N283S probably damaging Het
Smg5 A G 3: 88,359,644 probably benign Het
Stard9 A G 2: 120,701,368 E2702G probably benign Het
Tbk1 A T 10: 121,559,871 M439K probably benign Het
Tmem235 T C 11: 117,862,306 L85P possibly damaging Het
Trhde A T 10: 114,588,500 V460E possibly damaging Het
Ttn T C 2: 76,790,264 probably benign Het
Vmn1r83 A G 7: 12,321,233 F299S probably benign Het
Other mutations in Olfr1408
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00323:Olfr1408 APN 1 173130411 nonsense probably null
IGL01816:Olfr1408 APN 1 173130273 utr 3 prime probably benign
IGL02543:Olfr1408 APN 1 173130334 missense probably damaging 0.99
IGL03104:Olfr1408 APN 1 173130959 missense probably benign 0.00
IGL03183:Olfr1408 APN 1 173130858 missense probably damaging 0.97
R0940:Olfr1408 UTSW 1 173130453 missense probably benign 0.42
R1835:Olfr1408 UTSW 1 173130815 missense probably benign 0.00
R1993:Olfr1408 UTSW 1 173130851 missense possibly damaging 0.65
R1994:Olfr1408 UTSW 1 173130851 missense possibly damaging 0.65
R4438:Olfr1408 UTSW 1 173130302 missense probably benign 0.02
R4948:Olfr1408 UTSW 1 173130959 missense probably benign 0.00
R5088:Olfr1408 UTSW 1 173131039 missense probably damaging 1.00
R5117:Olfr1408 UTSW 1 173130917 missense possibly damaging 0.91
R5118:Olfr1408 UTSW 1 173130917 missense possibly damaging 0.91
R5344:Olfr1408 UTSW 1 173131106 missense probably benign 0.16
R8176:Olfr1408 UTSW 1 173130816 missense probably benign 0.00
X0018:Olfr1408 UTSW 1 173130699 missense probably benign 0.02
Posted On2013-10-07