Incidental Mutation 'IGL01371:Tmem235'
ID76139
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem235
Ensembl Gene ENSMUSG00000070330
Gene Nametransmembrane protein 235
SynonymsGm12581, Tmem235
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #IGL01371
Quality Score
Status
Chromosome11
Chromosomal Location117860752-117865543 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 117862306 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 85 (L85P)
Ref Sequence ENSEMBL: ENSMUSP00000091432 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093905]
Predicted Effect possibly damaging
Transcript: ENSMUST00000093905
AA Change: L85P

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000091432
Gene: ENSMUSG00000070330
AA Change: L85P

DomainStartEndE-ValueType
Pfam:PMP22_Claudin 4 190 9.7e-14 PFAM
Pfam:Claudin_2 16 192 1.3e-45 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1300017J02Rik T C 9: 103,254,776 E504G possibly damaging Het
Abcc9 C T 6: 142,656,614 R691Q probably benign Het
AI314180 A G 4: 58,809,718 L1583P probably damaging Het
Ambra1 G T 2: 91,825,286 G700W probably damaging Het
Atp6v1c1 A G 15: 38,682,960 I198V probably benign Het
Bptf T C 11: 107,055,907 N2353S probably benign Het
Cd84 A T 1: 171,886,370 T312S probably benign Het
Chl1 G T 6: 103,715,364 C1064F probably damaging Het
Clca4a T C 3: 144,960,672 D473G probably damaging Het
Dsp A G 13: 38,193,617 R1793G probably benign Het
Dync1h1 A G 12: 110,638,851 N2374S probably benign Het
Gm43191 A T 3: 116,645,463 I130N probably damaging Het
Gm5134 T G 10: 76,004,747 L475R probably damaging Het
Grm1 A G 10: 10,720,039 V615A probably benign Het
Loxl1 T A 9: 58,294,422 Q462L possibly damaging Het
Nwd1 T C 8: 72,675,115 W755R probably damaging Het
Olfr1102 A T 2: 87,002,923 K318M probably benign Het
Olfr1408 A G 1: 173,130,531 S229P possibly damaging Het
Olfr1459 G A 19: 13,145,828 T277I possibly damaging Het
Otud4 T C 8: 79,673,761 F1034L probably damaging Het
Pakap C A 4: 57,856,325 D551E probably benign Het
Panx3 T G 9: 37,661,475 T260P probably benign Het
Ppfia4 A T 1: 134,328,086 S194T probably benign Het
Rnf135 T A 11: 80,189,255 I124N probably benign Het
Rpf1 T C 3: 146,507,547 N283S probably damaging Het
Smg5 A G 3: 88,359,644 probably benign Het
Stard9 A G 2: 120,701,368 E2702G probably benign Het
Tbk1 A T 10: 121,559,871 M439K probably benign Het
Trhde A T 10: 114,588,500 V460E possibly damaging Het
Ttn T C 2: 76,790,264 probably benign Het
Vmn1r83 A G 7: 12,321,233 F299S probably benign Het
Other mutations in Tmem235
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0497:Tmem235 UTSW 11 117864351 missense probably benign 0.01
R0564:Tmem235 UTSW 11 117860848 missense possibly damaging 0.86
R3778:Tmem235 UTSW 11 117862300 missense probably benign 0.08
R5364:Tmem235 UTSW 11 117864194 nonsense probably null
R6064:Tmem235 UTSW 11 117862938 missense possibly damaging 0.84
R7139:Tmem235 UTSW 11 117860897 missense probably damaging 0.99
R7567:Tmem235 UTSW 11 117864141 missense probably benign 0.04
R7884:Tmem235 UTSW 11 117864207 missense probably benign 0.08
R7904:Tmem235 UTSW 11 117860891 missense probably damaging 1.00
X0063:Tmem235 UTSW 11 117862294 missense probably benign 0.08
Posted On2013-10-07