Incidental Mutation 'IGL01372:Or5ac24'
ID 76190
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5ac24
Ensembl Gene ENSMUSG00000066257
Gene Name olfactory receptor family 5 subfamily AC member 24
Synonyms MOR182-4, GA_x54KRFPKG5P-55560552-55559632, Olfr206
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # IGL01372
Quality Score
Status
Chromosome 16
Chromosomal Location 59165085-59166089 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59165524 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 180 (I180T)
Ref Sequence ENSEMBL: ENSMUSP00000146906 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084791] [ENSMUST00000207927]
AlphaFold Q8VGP9
Predicted Effect probably damaging
Transcript: ENSMUST00000084791
AA Change: I180T

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000081849
Gene: ENSMUSG00000066257
AA Change: I180T

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 6.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 34 295 2.6e-5 PFAM
Pfam:7tm_1 40 289 3.7e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207927
AA Change: I180T

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 G A 10: 79,842,089 (GRCm39) D1049N probably benign Het
Ankdd1a A T 9: 65,411,421 (GRCm39) L362Q probably damaging Het
Ankib1 A T 5: 3,822,594 (GRCm39) N37K probably damaging Het
Ankrd55 T A 13: 112,459,677 (GRCm39) D90E probably damaging Het
Atp1a2 T C 1: 172,106,510 (GRCm39) R831G probably damaging Het
Bcar3 A G 3: 122,316,943 (GRCm39) D638G probably damaging Het
Cabp4 T A 19: 4,189,322 (GRCm39) E78D probably benign Het
Cmtm8 A G 9: 114,619,755 (GRCm39) V130A possibly damaging Het
Cyth3 A G 5: 143,678,393 (GRCm39) T66A possibly damaging Het
Dmbt1 A T 7: 130,705,409 (GRCm39) I1171F possibly damaging Het
Dnah10 G A 5: 124,856,218 (GRCm39) G2060D probably damaging Het
Dnah11 T C 12: 118,156,134 (GRCm39) H172R probably damaging Het
Dnah5 C T 15: 28,230,636 (GRCm39) A178V probably benign Het
Efcab6 T G 15: 83,928,505 (GRCm39) M30L possibly damaging Het
Ehbp1l1 T C 19: 5,765,817 (GRCm39) probably benign Het
Eps15 G A 4: 109,179,303 (GRCm39) E230K probably damaging Het
Fam91a1 A G 15: 58,301,911 (GRCm39) I258M probably damaging Het
Gm5581 G A 6: 131,145,366 (GRCm39) noncoding transcript Het
Hrh1 G A 6: 114,456,958 (GRCm39) V80I probably damaging Het
Ldhd G A 8: 112,355,032 (GRCm39) H290Y probably benign Het
Lepr G A 4: 101,592,774 (GRCm39) E130K possibly damaging Het
Mycbpap T C 11: 94,397,282 (GRCm39) I40V possibly damaging Het
Nrap T A 19: 56,317,534 (GRCm39) probably null Het
Opn5 T A 17: 42,891,435 (GRCm39) probably null Het
Or1j14 T A 2: 36,417,463 (GRCm39) I13N probably benign Het
Otop3 A T 11: 115,235,930 (GRCm39) T521S possibly damaging Het
Pcsk5 T G 19: 17,595,108 (GRCm39) T409P probably damaging Het
Pde9a T A 17: 31,680,685 (GRCm39) F322Y probably benign Het
Pgm5 T A 19: 24,710,985 (GRCm39) I406F probably damaging Het
Prrc2b T C 2: 32,113,942 (GRCm39) S1998P probably damaging Het
Prune2 T C 19: 17,102,433 (GRCm39) Y2531H probably damaging Het
Ptprk T C 10: 28,445,923 (GRCm39) V932A probably benign Het
Rapgef6 T A 11: 54,559,437 (GRCm39) probably benign Het
Rgsl1 T A 1: 153,701,887 (GRCm39) Y224F probably damaging Het
Rps6kl1 A T 12: 85,193,663 (GRCm39) C143S probably damaging Het
S100a7l2 A G 3: 90,995,616 (GRCm39) probably benign Het
Slc5a5 G A 8: 71,343,020 (GRCm39) probably benign Het
Tfb2m A G 1: 179,369,878 (GRCm39) S182P probably damaging Het
Tmc3 A G 7: 83,261,746 (GRCm39) H608R probably damaging Het
Trim37 T A 11: 87,075,772 (GRCm39) H459Q probably benign Het
Vmn2r71 A T 7: 85,270,022 (GRCm39) probably benign Het
Xirp2 T C 2: 67,344,334 (GRCm39) S2192P possibly damaging Het
Other mutations in Or5ac24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02106:Or5ac24 APN 16 59,165,387 (GRCm39) missense probably benign 0.00
IGL02839:Or5ac24 APN 16 59,165,753 (GRCm39) missense probably benign 0.01
IGL03010:Or5ac24 APN 16 59,165,135 (GRCm39) utr 3 prime probably benign
R1163:Or5ac24 UTSW 16 59,165,425 (GRCm39) missense probably damaging 0.99
R1507:Or5ac24 UTSW 16 59,165,856 (GRCm39) missense probably damaging 1.00
R1670:Or5ac24 UTSW 16 59,165,790 (GRCm39) missense possibly damaging 0.79
R2881:Or5ac24 UTSW 16 59,165,215 (GRCm39) missense probably damaging 1.00
R2925:Or5ac24 UTSW 16 59,165,706 (GRCm39) nonsense probably null
R4479:Or5ac24 UTSW 16 59,165,230 (GRCm39) missense probably damaging 0.99
R4891:Or5ac24 UTSW 16 59,165,834 (GRCm39) missense possibly damaging 0.87
R5085:Or5ac24 UTSW 16 59,165,449 (GRCm39) missense probably damaging 0.99
R5099:Or5ac24 UTSW 16 59,165,266 (GRCm39) missense probably benign 0.00
R5218:Or5ac24 UTSW 16 59,165,270 (GRCm39) missense probably benign
R6019:Or5ac24 UTSW 16 59,165,798 (GRCm39) missense possibly damaging 0.48
R6773:Or5ac24 UTSW 16 59,165,579 (GRCm39) missense probably damaging 1.00
R7068:Or5ac24 UTSW 16 59,165,567 (GRCm39) missense possibly damaging 0.94
R7173:Or5ac24 UTSW 16 59,165,510 (GRCm39) missense probably benign 0.00
R7192:Or5ac24 UTSW 16 59,165,542 (GRCm39) missense probably benign 0.44
R7485:Or5ac24 UTSW 16 59,165,687 (GRCm39) missense probably damaging 1.00
R9005:Or5ac24 UTSW 16 59,165,929 (GRCm39) missense probably damaging 0.99
R9065:Or5ac24 UTSW 16 59,165,530 (GRCm39) missense probably damaging 1.00
R9090:Or5ac24 UTSW 16 59,165,145 (GRCm39) nonsense probably null
R9202:Or5ac24 UTSW 16 59,165,618 (GRCm39) missense probably benign 0.00
R9271:Or5ac24 UTSW 16 59,165,145 (GRCm39) nonsense probably null
R9559:Or5ac24 UTSW 16 59,165,368 (GRCm39) missense probably damaging 1.00
Posted On 2013-10-07