Incidental Mutation 'R0788:Tekt4'
ID76373
Institutional Source Beutler Lab
Gene Symbol Tekt4
Ensembl Gene ENSMUSG00000024175
Gene Nametektin 4
Synonyms
MMRRC Submission 038968-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.111) question?
Stock #R0788 (G1)
Quality Score192
Status Validated
Chromosome17
Chromosomal Location25471590-25476594 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 25472047 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Alanine at position 109 (D109A)
Ref Sequence ENSEMBL: ENSMUSP00000025002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025002]
Predicted Effect probably damaging
Transcript: ENSMUST00000025002
AA Change: D109A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000025002
Gene: ENSMUSG00000024175
AA Change: D109A

DomainStartEndE-ValueType
Pfam:Tektin 56 438 6.2e-143 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 96.9%
  • 20x: 93.0%
Validation Efficiency 98% (53/54)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit decreased male fertility due to abnormal flagellum function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik T A 13: 119,473,932 Y380* probably null Het
4931406B18Rik C A 7: 43,499,199 S196I probably damaging Het
Ablim2 T C 5: 35,857,901 S519P probably benign Het
Adnp2 A C 18: 80,130,004 C397G probably benign Het
Aldh1l2 A G 10: 83,516,164 S156P probably damaging Het
Bcl2l15 G T 3: 103,833,478 probably null Het
Brd9 T A 13: 73,944,867 probably benign Het
Cars2 A C 8: 11,529,672 I262R possibly damaging Het
Ccdc106 T C 7: 5,057,534 probably benign Het
Cdh3 G A 8: 106,541,415 V361M probably benign Het
Cdhr1 A C 14: 37,087,375 probably null Het
Cdk5rap2 A G 4: 70,307,231 I559T possibly damaging Het
Cdkn2aip T A 8: 47,713,763 Q3L possibly damaging Het
Chd1 G T 17: 15,707,114 V10F possibly damaging Het
Col4a4 G A 1: 82,524,996 P356S unknown Het
Col6a4 T C 9: 106,071,998 K813E probably benign Het
Cttnbp2 G A 6: 18,423,835 T830I probably damaging Het
Cyp2t4 A G 7: 27,155,163 M23V probably null Het
Cyp3a16 T C 5: 145,465,076 K59E probably benign Het
Dpysl5 G A 5: 30,788,841 probably null Het
E130308A19Rik T A 4: 59,719,847 Y460N possibly damaging Het
Ear6 T A 14: 51,854,030 C11* probably null Het
Fat1 C T 8: 45,023,983 T1999M probably benign Het
Gsdmd T A 15: 75,864,254 C77* probably null Het
Hsp90ab1 ACTTCTT ACTT 17: 45,569,499 probably benign Het
Kif28 A T 1: 179,705,223 probably benign Het
Krt6b A G 15: 101,677,519 I373T probably damaging Het
Lgr5 T C 10: 115,452,997 T509A probably damaging Het
Mapkbp1 C T 2: 120,024,001 P1354S probably benign Het
Nat10 A G 2: 103,743,115 S346P probably damaging Het
Ncoa2 T C 1: 13,166,889 probably benign Het
Necap1 C T 6: 122,881,536 R113W probably damaging Het
Olfr365 T A 2: 37,202,023 Y261N possibly damaging Het
Orc4 A T 2: 48,937,467 V38E possibly damaging Het
Per1 G A 11: 69,101,359 probably benign Het
Polb T C 8: 22,642,338 D130G probably null Het
Ppcs T C 4: 119,422,178 N59S probably damaging Het
Ppp2ca A G 11: 52,113,142 E42G possibly damaging Het
Ptprf T C 4: 118,226,466 T807A probably damaging Het
Rapgef2 A C 3: 79,099,195 F284V possibly damaging Het
Sestd1 A T 2: 77,191,716 F544I probably damaging Het
Slfn3 G A 11: 83,212,836 G178S possibly damaging Het
Supt6 G A 11: 78,207,772 probably benign Het
Tas2r109 T A 6: 132,980,301 Q222L probably benign Het
Tob2 C A 15: 81,851,702 R22L probably damaging Het
Ttn T G 2: 76,822,938 E178D possibly damaging Het
Ube2u C A 4: 100,514,740 probably benign Het
Uggt2 A G 14: 119,095,400 probably benign Het
Vstm2a T C 11: 16,259,968 F65L probably damaging Het
Zfp57 A G 17: 37,006,200 probably benign Het
Znrf3 G T 11: 5,281,320 P731Q probably benign Het
Other mutations in Tekt4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01571:Tekt4 APN 17 25476384 missense probably benign 0.31
IGL02657:Tekt4 APN 17 25473758 missense possibly damaging 0.93
R1280:Tekt4 UTSW 17 25471887 missense probably damaging 1.00
R1466:Tekt4 UTSW 17 25472074 missense probably benign 0.29
R1466:Tekt4 UTSW 17 25472074 missense probably benign 0.29
R1819:Tekt4 UTSW 17 25473811 splice site probably null
R1902:Tekt4 UTSW 17 25471858 missense possibly damaging 0.63
R2262:Tekt4 UTSW 17 25476511 missense possibly damaging 0.76
R2263:Tekt4 UTSW 17 25476511 missense possibly damaging 0.76
R4010:Tekt4 UTSW 17 25476486 missense probably damaging 1.00
R4604:Tekt4 UTSW 17 25471775 missense probably benign
R5085:Tekt4 UTSW 17 25473775 missense probably damaging 0.99
R6187:Tekt4 UTSW 17 25472223 missense probably damaging 1.00
R7102:Tekt4 UTSW 17 25474744 missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGGCTTCCGCACAGCCAAATAC -3'
(R):5'- CACTGGTTGCACCTTCAGTAGCTC -3'

Sequencing Primer
(F):5'- CAGCCAAATACCTGAGGGACG -3'
(R):5'- CATAGTCCCGGACAAGGTC -3'
Posted On2013-10-16