Incidental Mutation 'R0798:Tas1r2'
ID 76482
Institutional Source Beutler Lab
Gene Symbol Tas1r2
Ensembl Gene ENSMUSG00000028738
Gene Name taste receptor, type 1, member 2
Synonyms TR2, Gpr71, T1r2
MMRRC Submission 038978-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R0798 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 139380849-139397591 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 139397024 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 788 (Y788H)
Ref Sequence ENSEMBL: ENSMUSP00000127737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030510] [ENSMUST00000166773]
AlphaFold Q925I4
Predicted Effect probably damaging
Transcript: ENSMUST00000030510
AA Change: Y817H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000030510
Gene: ENSMUSG00000028738
AA Change: Y817H

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 73 459 2e-90 PFAM
Pfam:NCD3G 495 548 2.4e-17 PFAM
Pfam:7tm_3 581 818 2.8e-33 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000166773
AA Change: Y788H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000127737
Gene: ENSMUSG00000028738
AA Change: Y788H

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 73 213 5.3e-38 PFAM
Pfam:ANF_receptor 217 429 8.4e-31 PFAM
Pfam:NCD3G 466 519 7.4e-19 PFAM
Pfam:7tm_3 550 790 3e-47 PFAM
Meta Mutation Damage Score 0.2283 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency 100% (30/30)
MGI Phenotype PHENOTYPE: Homozygous mutant mice show diminished behavioral and nervous responses to sweet tastants. Response to umami tastants is unimpaired. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T C 9: 124,057,789 (GRCm39) probably benign Het
4930579C12Rik T A 9: 89,034,880 (GRCm39) noncoding transcript Het
Baz2a T A 10: 127,962,192 (GRCm39) probably benign Het
Bcar3 T C 3: 122,318,948 (GRCm39) V695A probably benign Het
C130074G19Rik G A 1: 184,614,873 (GRCm39) probably benign Het
Cmas T C 6: 142,710,382 (GRCm39) V167A probably damaging Het
Crppa G A 12: 36,571,998 (GRCm39) R302H probably benign Het
Cyp3a25 T C 5: 145,928,343 (GRCm39) E234G probably damaging Het
Gopc C T 10: 52,234,907 (GRCm39) G79S probably damaging Het
Herc2 T A 7: 55,785,431 (GRCm39) probably null Het
Iqca1 C A 1: 90,070,453 (GRCm39) G133V probably null Het
Kcnq5 A G 1: 22,031,399 (GRCm39) probably null Het
Lpp G T 16: 24,790,622 (GRCm39) G29* probably null Het
Ly6g6e T C 17: 35,297,017 (GRCm39) F86S probably benign Het
Myo5c T C 9: 75,165,266 (GRCm39) F358S probably damaging Het
Nlgn1 A G 3: 25,488,410 (GRCm39) Y613H probably benign Het
Or4k38 T C 2: 111,165,689 (GRCm39) I245V probably benign Het
Or7e178 A T 9: 20,225,495 (GRCm39) Y232* probably null Het
Plekhn1 T A 4: 156,312,720 (GRCm39) D46V probably damaging Het
Ptp4a1 A T 1: 30,984,005 (GRCm39) probably benign Het
Rab23 A T 1: 33,773,908 (GRCm39) I123F probably damaging Het
Samd4b G A 7: 28,101,048 (GRCm39) probably benign Het
Shisa4 G A 1: 135,300,886 (GRCm39) probably benign Het
Slc39a11 C T 11: 113,414,330 (GRCm39) A90T probably benign Het
Tasor T A 14: 27,198,593 (GRCm39) F1308L probably damaging Het
Tial1 C T 7: 128,045,602 (GRCm39) M327I probably benign Het
Ubr2 C T 17: 47,280,102 (GRCm39) probably benign Het
Utp4 T C 8: 107,648,858 (GRCm39) S630P probably benign Het
Vmn1r212 T C 13: 23,067,868 (GRCm39) N155S probably damaging Het
Zmym6 C T 4: 126,997,316 (GRCm39) P312S probably benign Het
Other mutations in Tas1r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00911:Tas1r2 APN 4 139,387,602 (GRCm39) missense probably benign 0.03
IGL00952:Tas1r2 APN 4 139,382,563 (GRCm39) missense probably benign 0.00
IGL00972:Tas1r2 APN 4 139,387,347 (GRCm39) missense probably damaging 0.99
IGL01939:Tas1r2 APN 4 139,396,488 (GRCm39) missense probably damaging 1.00
IGL02247:Tas1r2 APN 4 139,396,827 (GRCm39) missense probably damaging 1.00
IGL02663:Tas1r2 APN 4 139,387,593 (GRCm39) missense probably benign
IGL03155:Tas1r2 APN 4 139,396,467 (GRCm39) missense possibly damaging 0.95
R0395:Tas1r2 UTSW 4 139,382,665 (GRCm39) missense possibly damaging 0.86
R1221:Tas1r2 UTSW 4 139,396,436 (GRCm39) missense probably benign 0.00
R1223:Tas1r2 UTSW 4 139,387,515 (GRCm39) missense probably damaging 1.00
R1261:Tas1r2 UTSW 4 139,382,599 (GRCm39) missense probably damaging 0.99
R1262:Tas1r2 UTSW 4 139,382,599 (GRCm39) missense probably damaging 0.99
R1330:Tas1r2 UTSW 4 139,396,640 (GRCm39) missense probably benign 0.05
R1466:Tas1r2 UTSW 4 139,396,722 (GRCm39) missense probably damaging 1.00
R1466:Tas1r2 UTSW 4 139,396,722 (GRCm39) missense probably damaging 1.00
R1879:Tas1r2 UTSW 4 139,397,006 (GRCm39) missense probably damaging 1.00
R2112:Tas1r2 UTSW 4 139,382,666 (GRCm39) missense probably benign 0.00
R2156:Tas1r2 UTSW 4 139,396,352 (GRCm39) missense possibly damaging 0.79
R2509:Tas1r2 UTSW 4 139,387,162 (GRCm39) missense probably damaging 1.00
R2510:Tas1r2 UTSW 4 139,387,162 (GRCm39) missense probably damaging 1.00
R2511:Tas1r2 UTSW 4 139,387,162 (GRCm39) missense probably damaging 1.00
R3429:Tas1r2 UTSW 4 139,396,886 (GRCm39) missense probably damaging 1.00
R3430:Tas1r2 UTSW 4 139,396,886 (GRCm39) missense probably damaging 1.00
R3703:Tas1r2 UTSW 4 139,394,729 (GRCm39) missense probably damaging 1.00
R4105:Tas1r2 UTSW 4 139,387,363 (GRCm39) missense probably benign 0.06
R4106:Tas1r2 UTSW 4 139,387,363 (GRCm39) missense probably benign 0.06
R4107:Tas1r2 UTSW 4 139,387,363 (GRCm39) missense probably benign 0.06
R4614:Tas1r2 UTSW 4 139,387,098 (GRCm39) missense probably damaging 1.00
R4811:Tas1r2 UTSW 4 139,396,311 (GRCm39) missense probably damaging 1.00
R5314:Tas1r2 UTSW 4 139,382,672 (GRCm39) missense probably damaging 1.00
R5461:Tas1r2 UTSW 4 139,387,320 (GRCm39) missense probably benign 0.01
R5639:Tas1r2 UTSW 4 139,387,107 (GRCm39) missense probably damaging 1.00
R5703:Tas1r2 UTSW 4 139,394,647 (GRCm39) missense probably damaging 1.00
R6176:Tas1r2 UTSW 4 139,396,199 (GRCm39) missense probably damaging 1.00
R6297:Tas1r2 UTSW 4 139,389,361 (GRCm39) missense possibly damaging 0.47
R6441:Tas1r2 UTSW 4 139,396,467 (GRCm39) missense probably damaging 0.99
R6748:Tas1r2 UTSW 4 139,396,922 (GRCm39) missense probably damaging 0.98
R6863:Tas1r2 UTSW 4 139,397,030 (GRCm39) missense probably damaging 1.00
R6975:Tas1r2 UTSW 4 139,397,031 (GRCm39) missense probably damaging 1.00
R7106:Tas1r2 UTSW 4 139,389,360 (GRCm39) missense probably benign
R7265:Tas1r2 UTSW 4 139,396,963 (GRCm39) missense probably benign 0.01
R7580:Tas1r2 UTSW 4 139,387,056 (GRCm39) missense probably benign 0.05
R7651:Tas1r2 UTSW 4 139,396,938 (GRCm39) missense probably benign 0.14
R8041:Tas1r2 UTSW 4 139,387,290 (GRCm39) missense possibly damaging 0.65
R8530:Tas1r2 UTSW 4 139,389,460 (GRCm39) missense probably benign
R8747:Tas1r2 UTSW 4 139,387,318 (GRCm39) missense probably benign
R8824:Tas1r2 UTSW 4 139,381,074 (GRCm39) splice site probably benign
R8904:Tas1r2 UTSW 4 139,394,714 (GRCm39) missense probably damaging 1.00
R8906:Tas1r2 UTSW 4 139,397,046 (GRCm39) missense probably damaging 1.00
R9315:Tas1r2 UTSW 4 139,381,046 (GRCm39) missense possibly damaging 0.91
R9336:Tas1r2 UTSW 4 139,389,316 (GRCm39) missense probably damaging 1.00
R9419:Tas1r2 UTSW 4 139,387,036 (GRCm39) missense possibly damaging 0.65
R9776:Tas1r2 UTSW 4 139,396,208 (GRCm39) missense possibly damaging 0.68
Z1088:Tas1r2 UTSW 4 139,387,735 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- GCTACTCTTCAACACCAGCATGGAC -3'
(R):5'- CATCCTTGGAGCCACATAGGTCAC -3'

Sequencing Primer
(F):5'- AGCATGGACTTGCTGCTG -3'
(R):5'- GTAGGTCCTAGCCAGTGAAC -3'
Posted On 2013-10-16