Incidental Mutation 'R0781:Hnrnpul2'
ID 76658
Institutional Source Beutler Lab
Gene Symbol Hnrnpul2
Ensembl Gene ENSMUSG00000071659
Gene Name heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms 1110031M08Rik, Hnrpul2
MMRRC Submission 038961-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.865) question?
Stock # R0781 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 8797374-8811507 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 8804110 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 570 (R570G)
Ref Sequence ENSEMBL: ENSMUSP00000094515 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096753]
AlphaFold Q00PI9
Predicted Effect probably damaging
Transcript: ENSMUST00000096753
AA Change: R570G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000094515
Gene: ENSMUSG00000071659
AA Change: R570G

DomainStartEndE-ValueType
SAP 3 37 6.03e-9 SMART
low complexity region 68 126 N/A INTRINSIC
low complexity region 224 240 N/A INTRINSIC
SPRY 287 416 5.23e-32 SMART
Pfam:AAA_33 452 597 1.2e-25 PFAM
low complexity region 637 666 N/A INTRINSIC
low complexity region 700 719 N/A INTRINSIC
low complexity region 728 745 N/A INTRINSIC
Meta Mutation Damage Score 0.6697 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.0%
  • 20x: 93.2%
Validation Efficiency 97% (67/69)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921513D11Rik G T 17: 79,935,180 (GRCm39) A98S probably benign Het
Acp2 A G 2: 91,038,767 (GRCm39) probably null Het
Akap13 T G 7: 75,261,125 (GRCm39) S447A possibly damaging Het
Alk G A 17: 72,291,740 (GRCm39) probably benign Het
Ankrd55 A G 13: 112,517,767 (GRCm39) probably benign Het
Arhgef39 T C 4: 43,496,834 (GRCm39) T327A probably benign Het
Calhm5 T G 10: 33,972,013 (GRCm39) I141L probably benign Het
Cdan1 G A 2: 120,551,083 (GRCm39) A1103V probably damaging Het
Cdk17 T A 10: 93,074,895 (GRCm39) Y3* probably null Het
Cdon T C 9: 35,367,733 (GRCm39) probably benign Het
Cntn3 T A 6: 102,222,119 (GRCm39) N460I probably benign Het
Cntrl T A 2: 35,050,639 (GRCm39) C985S possibly damaging Het
Col6a2 T C 10: 76,443,574 (GRCm39) E497G probably benign Het
Crybg1 A G 10: 43,875,089 (GRCm39) M673T possibly damaging Het
Csmd1 A C 8: 15,971,174 (GRCm39) I3047S probably benign Het
Cyp2u1 A G 3: 131,087,258 (GRCm39) I441T possibly damaging Het
Disp2 T C 2: 118,620,920 (GRCm39) S551P probably damaging Het
Dstyk A G 1: 132,381,063 (GRCm39) probably benign Het
Frem1 T C 4: 82,868,557 (GRCm39) S1457G probably damaging Het
Gabbr2 C T 4: 46,718,838 (GRCm39) C613Y probably damaging Het
Gdf7 C A 12: 8,351,555 (GRCm39) probably benign Het
Ift70a1 A T 2: 75,810,320 (GRCm39) C588S probably damaging Het
Iqcf4 T C 9: 106,445,860 (GRCm39) I96V probably benign Het
Iqck G A 7: 118,498,880 (GRCm39) D173N possibly damaging Het
Itpr3 C T 17: 27,329,529 (GRCm39) H1518Y probably benign Het
Kdm5d T A Y: 910,539 (GRCm39) L250H probably damaging Het
Kntc1 C T 5: 123,937,965 (GRCm39) probably benign Het
Lmtk3 T A 7: 45,444,427 (GRCm39) probably benign Het
Lpin3 A G 2: 160,735,999 (GRCm39) D93G probably benign Het
Ncoa6 A T 2: 155,253,440 (GRCm39) probably benign Het
Nudt7 G A 8: 114,862,111 (GRCm39) probably benign Het
Nup160 A G 2: 90,563,563 (GRCm39) probably benign Het
Oit3 G A 10: 59,264,016 (GRCm39) R373C probably damaging Het
Olfml2a A T 2: 38,849,765 (GRCm39) I494L probably damaging Het
Opa3 A G 7: 18,962,524 (GRCm39) probably benign Het
Or51e2 A G 7: 102,392,214 (GRCm39) probably benign Het
Or5ac15 A T 16: 58,940,187 (GRCm39) V82D probably damaging Het
Or9r7 A G 10: 129,962,522 (GRCm39) Y135H probably damaging Het
Pak3 TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC X: 142,526,889 (GRCm39) probably benign Het
Parp6 G T 9: 59,556,847 (GRCm39) C584F probably damaging Het
Pcgf2 A G 11: 97,582,676 (GRCm39) probably benign Het
Pde3a T C 6: 141,405,042 (GRCm39) probably benign Het
Pitrm1 A G 13: 6,608,280 (GRCm39) D335G probably benign Het
Pkhd1 A T 1: 20,187,708 (GRCm39) N3533K probably benign Het
Pkp4 T C 2: 59,169,109 (GRCm39) L752P probably damaging Het
Plcb3 C A 19: 6,939,281 (GRCm39) E566* probably null Het
Ppef2 T C 5: 92,392,689 (GRCm39) K261R probably benign Het
Prdm14 A G 1: 13,184,585 (GRCm39) S529P probably damaging Het
Prune2 T C 19: 17,102,586 (GRCm39) S2582P probably benign Het
Sardh G A 2: 27,081,931 (GRCm39) T865I possibly damaging Het
Slc26a3 A T 12: 31,515,812 (GRCm39) I571F possibly damaging Het
Slc5a5 A T 8: 71,342,864 (GRCm39) M232K probably benign Het
Slc9a1 T A 4: 133,097,859 (GRCm39) M2K probably benign Het
Spata31e3 A T 13: 50,402,296 (GRCm39) D83E possibly damaging Het
Ss18l1 G A 2: 179,697,647 (GRCm39) S177N possibly damaging Het
Svs5 A T 2: 164,175,507 (GRCm39) I120L probably benign Het
Tcl1b1 G T 12: 105,126,074 (GRCm39) V19F probably damaging Het
Tmem108 C T 9: 103,361,889 (GRCm39) V566M probably damaging Het
Trmu C A 15: 85,763,604 (GRCm39) C9* probably null Het
Vnn1 A T 10: 23,775,499 (GRCm39) I250F possibly damaging Het
Vps13c T A 9: 67,879,285 (GRCm39) Y3409N probably damaging Het
Xrn1 T A 9: 95,873,322 (GRCm39) N695K probably benign Het
Zfp84 T A 7: 29,470,797 (GRCm39) M1K probably null Het
Zfyve26 G A 12: 79,326,841 (GRCm39) R761C probably damaging Het
Zp3r A G 1: 130,505,621 (GRCm39) probably null Het
Other mutations in Hnrnpul2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01989:Hnrnpul2 APN 19 8,800,992 (GRCm39) missense probably damaging 1.00
R0136:Hnrnpul2 UTSW 19 8,804,165 (GRCm39) missense probably damaging 1.00
R0369:Hnrnpul2 UTSW 19 8,801,777 (GRCm39) missense probably damaging 1.00
R0784:Hnrnpul2 UTSW 19 8,802,416 (GRCm39) missense possibly damaging 0.82
R1110:Hnrnpul2 UTSW 19 8,804,110 (GRCm39) missense probably damaging 1.00
R1227:Hnrnpul2 UTSW 19 8,800,601 (GRCm39) missense possibly damaging 0.91
R1589:Hnrnpul2 UTSW 19 8,808,696 (GRCm39) missense probably benign 0.00
R2126:Hnrnpul2 UTSW 19 8,801,802 (GRCm39) nonsense probably null
R2226:Hnrnpul2 UTSW 19 8,802,349 (GRCm39) missense probably damaging 0.96
R2243:Hnrnpul2 UTSW 19 8,798,001 (GRCm39) missense probably benign
R3703:Hnrnpul2 UTSW 19 8,801,773 (GRCm39) missense probably damaging 1.00
R4038:Hnrnpul2 UTSW 19 8,800,591 (GRCm39) unclassified probably benign
R4856:Hnrnpul2 UTSW 19 8,807,191 (GRCm39) missense probably benign 0.20
R4886:Hnrnpul2 UTSW 19 8,807,191 (GRCm39) missense probably benign 0.20
R5016:Hnrnpul2 UTSW 19 8,800,189 (GRCm39) missense possibly damaging 0.94
R5365:Hnrnpul2 UTSW 19 8,798,080 (GRCm39) missense probably benign
R5435:Hnrnpul2 UTSW 19 8,797,682 (GRCm39) missense probably benign 0.32
R5951:Hnrnpul2 UTSW 19 8,802,255 (GRCm39) missense probably damaging 1.00
R6181:Hnrnpul2 UTSW 19 8,800,596 (GRCm39) missense possibly damaging 0.70
R6824:Hnrnpul2 UTSW 19 8,804,081 (GRCm39) missense possibly damaging 0.89
R6924:Hnrnpul2 UTSW 19 8,808,873 (GRCm39) missense unknown
R6978:Hnrnpul2 UTSW 19 8,801,640 (GRCm39) missense probably damaging 1.00
R7602:Hnrnpul2 UTSW 19 8,808,673 (GRCm39) missense probably damaging 0.99
R7688:Hnrnpul2 UTSW 19 8,797,994 (GRCm39) missense probably benign
R7726:Hnrnpul2 UTSW 19 8,808,644 (GRCm39) missense possibly damaging 0.61
R7749:Hnrnpul2 UTSW 19 8,797,788 (GRCm39) missense probably benign
R7753:Hnrnpul2 UTSW 19 8,802,336 (GRCm39) missense probably damaging 1.00
R8007:Hnrnpul2 UTSW 19 8,798,179 (GRCm39) critical splice donor site probably null
R8725:Hnrnpul2 UTSW 19 8,798,064 (GRCm39) missense probably benign 0.00
R8727:Hnrnpul2 UTSW 19 8,798,064 (GRCm39) missense probably benign 0.00
R8901:Hnrnpul2 UTSW 19 8,801,809 (GRCm39) missense probably damaging 0.98
R8994:Hnrnpul2 UTSW 19 8,802,350 (GRCm39) missense probably damaging 1.00
R9012:Hnrnpul2 UTSW 19 8,801,829 (GRCm39) missense possibly damaging 0.69
R9187:Hnrnpul2 UTSW 19 8,808,319 (GRCm39) missense probably benign 0.28
R9347:Hnrnpul2 UTSW 19 8,798,080 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGTCTGGGATCACATGTAGAACGGAAT -3'
(R):5'- CCTTAGATGTGGAGAGTCACTCTTGGT -3'

Sequencing Primer
(F):5'- ggtggtagatggagagaaagg -3'
(R):5'- AGAGTCACTCTTGGTGATAAGC -3'
Posted On 2013-10-16