Incidental Mutation 'P0043:Lrrc74b'
ID7666
Institutional Source Beutler Lab
Gene Symbol Lrrc74b
Ensembl Gene ENSMUSG00000022759
Gene Nameleucine rich repeat containing 74B
Synonyms4930451C15Rik
MMRRC Submission 038291-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.178) question?
Stock #P0043 (G1)
Quality Score
Status Validated
Chromosome16
Chromosomal Location17544465-17561247 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 17558159 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023441] [ENSMUST00000023442] [ENSMUST00000065125] [ENSMUST00000100123] [ENSMUST00000171002] [ENSMUST00000231806] [ENSMUST00000232637]
Predicted Effect probably benign
Transcript: ENSMUST00000023441
SMART Domains Protein: ENSMUSP00000023441
Gene: ENSMUSG00000022758

DomainStartEndE-ValueType
low complexity region 12 18 N/A INTRINSIC
Pfam:P2X_receptor 25 385 7.9e-139 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000023442
SMART Domains Protein: ENSMUSP00000023442
Gene: ENSMUSG00000022759

DomainStartEndE-ValueType
LRR 71 103 3.9e0 SMART
LRR 104 131 1.04e-3 SMART
LRR 132 159 1.14e1 SMART
LRR 160 187 7.78e-3 SMART
LRR 188 215 3.9e0 SMART
LRR 216 243 7.89e-1 SMART
LRR 244 271 6.78e-3 SMART
LRR 272 299 5.51e-1 SMART
low complexity region 342 355 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000065125
SMART Domains Protein: ENSMUSP00000070127
Gene: ENSMUSG00000022759

DomainStartEndE-ValueType
LRR 71 103 3.9e0 SMART
LRR 104 131 1.04e-3 SMART
LRR 132 159 1.14e1 SMART
LRR 160 187 7.78e-3 SMART
LRR 188 215 3.9e0 SMART
LRR 216 243 7.89e-1 SMART
LRR 244 271 6.78e-3 SMART
LRR 272 299 5.51e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000100123
SMART Domains Protein: ENSMUSP00000097699
Gene: ENSMUSG00000022759

DomainStartEndE-ValueType
LRR 71 103 3.9e0 SMART
LRR 104 131 1.04e-3 SMART
LRR 132 159 1.14e1 SMART
LRR 160 187 7.78e-3 SMART
LRR 188 215 3.9e0 SMART
LRR 216 243 7.89e-1 SMART
LRR 244 271 6.78e-3 SMART
LRR 272 299 5.51e-1 SMART
LRR 300 327 4.16e0 SMART
low complexity region 374 387 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138839
Predicted Effect probably benign
Transcript: ENSMUST00000171002
SMART Domains Protein: ENSMUSP00000132727
Gene: ENSMUSG00000022758

DomainStartEndE-ValueType
low complexity region 12 18 N/A INTRINSIC
Pfam:P2X_receptor 25 197 1e-65 PFAM
Pfam:P2X_receptor 185 362 7e-63 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231806
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232230
Predicted Effect probably benign
Transcript: ENSMUST00000232637
Coding Region Coverage
  • 1x: 81.5%
  • 3x: 74.1%
  • 10x: 50.1%
  • 20x: 26.7%
Validation Efficiency 74% (145/195)
Allele List at MGI
Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Chn1 A T 2: 73,624,165 V247E probably damaging Het
Col28a1 T A 6: 8,168,152 probably benign Het
Cxcl5 A G 5: 90,759,967 I85M probably damaging Het
Fnip1 A G 11: 54,503,225 E829G probably benign Het
Kctd18 G A 1: 57,967,563 R43C probably damaging Het
Kidins220 T A 12: 25,008,156 F629I probably damaging Het
Lamb1 T C 12: 31,278,621 S195P probably damaging Het
Mrpl30 A G 1: 37,898,178 T133A probably benign Het
Mrps27 A G 13: 99,412,246 T297A probably benign Het
Per1 G T 11: 69,102,043 probably benign Het
Ptprq C A 10: 107,580,225 M1737I probably benign Het
Ropn1l A C 15: 31,457,301 probably benign Het
Sfrp4 A G 13: 19,623,595 I55V probably benign Het
Spata31 G A 13: 64,921,006 probably null Het
Trpm6 T A 19: 18,877,765 D1929E probably damaging Het
Ttn A G 2: 76,798,014 S12855P probably damaging Het
Zscan10 C T 17: 23,609,620 R302* probably null Het
Other mutations in Lrrc74b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01810:Lrrc74b APN 16 17545558 missense probably benign 0.00
IGL02402:Lrrc74b APN 16 17558164 splice site probably benign
R0131:Lrrc74b UTSW 16 17553152 missense probably damaging 1.00
R0131:Lrrc74b UTSW 16 17553152 missense probably damaging 1.00
R0132:Lrrc74b UTSW 16 17553152 missense probably damaging 1.00
R0829:Lrrc74b UTSW 16 17558390 splice site probably benign
R1463:Lrrc74b UTSW 16 17559873 missense probably benign 0.00
R1681:Lrrc74b UTSW 16 17559753 missense probably damaging 1.00
R1938:Lrrc74b UTSW 16 17553194 missense probably benign 0.41
R4790:Lrrc74b UTSW 16 17549853 missense probably damaging 1.00
R5428:Lrrc74b UTSW 16 17558261 missense probably damaging 0.99
R6198:Lrrc74b UTSW 16 17548786 missense probably damaging 0.96
R7910:Lrrc74b UTSW 16 17558349 nonsense probably null
R7991:Lrrc74b UTSW 16 17558349 nonsense probably null
X0063:Lrrc74b UTSW 16 17553208 missense probably benign 0.05
Z1177:Lrrc74b UTSW 16 17558168 critical splice donor site probably null
Z1177:Lrrc74b UTSW 16 17558172 missense probably damaging 1.00
Posted On2012-10-29