Incidental Mutation 'R0784:Slc6a15'
ID 76779
Institutional Source Beutler Lab
Gene Symbol Slc6a15
Ensembl Gene ENSMUSG00000019894
Gene Name solute carrier family 6 (neurotransmitter transporter), member 15
Synonyms v7-3
MMRRC Submission 038964-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0784 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 103367783-103419377 bp(+) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 103416800 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000136676 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074204] [ENSMUST00000179636]
AlphaFold Q8BG16
Predicted Effect probably benign
Transcript: ENSMUST00000074204
SMART Domains Protein: ENSMUSP00000073829
Gene: ENSMUSG00000019894

DomainStartEndE-ValueType
low complexity region 29 38 N/A INTRINSIC
Pfam:SNF 61 644 2.2e-229 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000179636
SMART Domains Protein: ENSMUSP00000136676
Gene: ENSMUSG00000019894

DomainStartEndE-ValueType
low complexity region 29 38 N/A INTRINSIC
Pfam:SNF 61 644 2.2e-229 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.9%
  • 10x: 96.9%
  • 20x: 92.1%
Validation Efficiency 97% (59/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased synaptosome transport activities but exhibit no behavioral abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acin1 T C 14: 54,653,528 (GRCm38) probably benign Het
Adamts2 C T 11: 50,668,003 (GRCm38) R182W probably damaging Het
Ahr C T 12: 35,508,142 (GRCm38) G293D possibly damaging Het
Akna G T 4: 63,376,888 (GRCm38) T1028K probably benign Het
Akp3 G A 1: 87,127,871 (GRCm38) G547R unknown Het
Asic2 T A 11: 80,893,989 (GRCm38) M324L possibly damaging Het
Atf6 A G 1: 170,709,947 (GRCm38) F635L probably benign Het
Atp8b2 A T 3: 89,957,073 (GRCm38) V195E probably damaging Het
Bicd1 T A 6: 149,513,363 (GRCm38) C525S probably damaging Het
Cbfa2t3 A G 8: 122,650,487 (GRCm38) probably benign Het
Cd46 G A 1: 195,092,194 (GRCm38) T11M possibly damaging Het
Cecr2 A G 6: 120,758,149 (GRCm38) H754R possibly damaging Het
Clcn3 G T 8: 60,929,203 (GRCm38) D450E probably benign Het
Cobl T G 11: 12,266,843 (GRCm38) probably benign Het
Cyba T A 8: 122,427,683 (GRCm38) T34S probably benign Het
Dennd1a A G 2: 38,021,414 (GRCm38) L187P probably damaging Het
Dennd4c A T 4: 86,844,908 (GRCm38) Q1817L probably benign Het
Drosha T C 15: 12,867,678 (GRCm38) probably benign Het
Dync1li2 A G 8: 104,442,498 (GRCm38) S34P probably damaging Het
Emilin2 T A 17: 71,275,287 (GRCm38) D148V possibly damaging Het
Galnt11 A G 5: 25,258,909 (GRCm38) D393G probably damaging Het
Gm5435 T A 12: 82,496,180 (GRCm38) noncoding transcript Het
Gpr176 C T 2: 118,373,052 (GRCm38) V46M possibly damaging Het
Gpr85 T A 6: 13,836,749 (GRCm38) H52L probably benign Het
Grn T C 11: 102,434,502 (GRCm38) M246T possibly damaging Het
Hnrnpul2 T C 19: 8,825,052 (GRCm38) F428L possibly damaging Het
Hoxa13 G C 6: 52,259,937 (GRCm38) N278K probably damaging Het
Irx5 A G 8: 92,360,490 (GRCm38) D350G probably benign Het
Kat2a C T 11: 100,710,841 (GRCm38) M249I probably benign Het
Klhl29 T C 12: 5,081,251 (GRCm38) Y782C probably damaging Het
Kmt2c A T 5: 25,310,895 (GRCm38) F2650Y probably benign Het
Lrp2 A G 2: 69,518,365 (GRCm38) I754T probably benign Het
Mpl G A 4: 118,446,406 (GRCm38) P472S possibly damaging Het
Mtnr1b A G 9: 15,862,785 (GRCm38) I326T probably benign Het
Myh9 A G 15: 77,777,009 (GRCm38) probably benign Het
Mylk G C 16: 34,879,475 (GRCm38) E403Q possibly damaging Het
Myo9a A G 9: 59,896,545 (GRCm38) probably benign Het
Olfr1187-ps1 T A 2: 88,540,167 (GRCm38) noncoding transcript Het
Olfr30 T A 11: 58,455,305 (GRCm38) I215F possibly damaging Het
Oraov1 A T 7: 144,919,277 (GRCm38) Y108F probably benign Het
Pcsk5 T C 19: 17,714,769 (GRCm38) M184V probably benign Het
Piezo2 T A 18: 63,083,235 (GRCm38) D1143V probably damaging Het
Prr36 G T 8: 4,213,771 (GRCm38) probably benign Het
Rnf220 C A 4: 117,277,998 (GRCm38) probably benign Het
Senp3 A G 11: 69,680,448 (GRCm38) L131P probably damaging Het
Shc4 A C 2: 125,657,496 (GRCm38) W354G probably benign Het
Smtnl2 T C 11: 72,399,937 (GRCm38) D394G probably damaging Het
Sry G T Y: 2,662,731 (GRCm38) Q310K unknown Het
St7l A G 3: 104,870,924 (GRCm38) M126V probably benign Het
St8sia3 T C 18: 64,271,701 (GRCm38) W350R probably damaging Het
Stk35 A T 2: 129,810,802 (GRCm38) K408* probably null Het
Svs1 T A 6: 48,987,301 (GRCm38) M81K possibly damaging Het
Thsd7b T C 1: 129,595,359 (GRCm38) probably benign Het
Tmem106b T C 6: 13,084,253 (GRCm38) V252A probably damaging Het
Trpm7 A G 2: 126,846,072 (GRCm38) probably null Het
Ttf2 T C 3: 100,962,710 (GRCm38) D349G probably benign Het
Zfp386 T A 12: 116,059,920 (GRCm38) C419* probably null Het
Zfp541 A G 7: 16,082,992 (GRCm38) probably benign Het
Other mutations in Slc6a15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00504:Slc6a15 APN 10 103,389,141 (GRCm38) missense probably benign
IGL01320:Slc6a15 APN 10 103,404,745 (GRCm38) missense probably benign 0.00
IGL01924:Slc6a15 APN 10 103,404,825 (GRCm38) splice site probably null
IGL02066:Slc6a15 APN 10 103,416,658 (GRCm38) missense probably damaging 0.98
IGL02164:Slc6a15 APN 10 103,418,222 (GRCm38) missense probably benign 0.01
IGL02551:Slc6a15 APN 10 103,404,275 (GRCm38) splice site probably benign
IGL02744:Slc6a15 APN 10 103,418,033 (GRCm38) missense probably benign 0.03
R0028:Slc6a15 UTSW 10 103,416,680 (GRCm38) missense probably benign 0.00
R0143:Slc6a15 UTSW 10 103,418,068 (GRCm38) missense probably benign 0.02
R0158:Slc6a15 UTSW 10 103,389,347 (GRCm38) splice site probably benign
R0165:Slc6a15 UTSW 10 103,409,809 (GRCm38) missense probably null 0.04
R0349:Slc6a15 UTSW 10 103,418,225 (GRCm38) missense probably benign 0.06
R0383:Slc6a15 UTSW 10 103,418,053 (GRCm38) missense probably damaging 1.00
R0614:Slc6a15 UTSW 10 103,404,352 (GRCm38) nonsense probably null
R0944:Slc6a15 UTSW 10 103,409,796 (GRCm38) missense probably benign 0.01
R1795:Slc6a15 UTSW 10 103,400,260 (GRCm38) missense probably benign
R1882:Slc6a15 UTSW 10 103,395,064 (GRCm38) missense probably benign 0.20
R2061:Slc6a15 UTSW 10 103,409,734 (GRCm38) missense probably benign 0.20
R2156:Slc6a15 UTSW 10 103,393,408 (GRCm38) missense probably damaging 1.00
R2358:Slc6a15 UTSW 10 103,416,785 (GRCm38) missense probably benign 0.00
R2849:Slc6a15 UTSW 10 103,404,691 (GRCm38) missense probably benign 0.01
R2921:Slc6a15 UTSW 10 103,418,387 (GRCm38) missense probably damaging 0.99
R3709:Slc6a15 UTSW 10 103,393,414 (GRCm38) missense probably benign 0.00
R4532:Slc6a15 UTSW 10 103,409,787 (GRCm38) missense possibly damaging 0.69
R4825:Slc6a15 UTSW 10 103,418,060 (GRCm38) missense probably benign 0.05
R4909:Slc6a15 UTSW 10 103,404,414 (GRCm38) missense probably damaging 1.00
R5112:Slc6a15 UTSW 10 103,389,226 (GRCm38) missense probably benign
R5320:Slc6a15 UTSW 10 103,408,206 (GRCm38) missense probably damaging 1.00
R5364:Slc6a15 UTSW 10 103,393,508 (GRCm38) missense probably damaging 0.99
R6305:Slc6a15 UTSW 10 103,389,170 (GRCm38) missense probably benign 0.31
R6348:Slc6a15 UTSW 10 103,404,367 (GRCm38) missense probably damaging 1.00
R6729:Slc6a15 UTSW 10 103,393,914 (GRCm38) missense probably damaging 0.99
R6781:Slc6a15 UTSW 10 103,395,067 (GRCm38) missense probably damaging 0.99
R7409:Slc6a15 UTSW 10 103,408,302 (GRCm38) missense probably benign
R7549:Slc6a15 UTSW 10 103,389,137 (GRCm38) missense probably benign
R7660:Slc6a15 UTSW 10 103,393,380 (GRCm38) splice site probably null
R7839:Slc6a15 UTSW 10 103,404,799 (GRCm38) missense probably benign
R7948:Slc6a15 UTSW 10 103,404,295 (GRCm38) missense possibly damaging 0.95
R8278:Slc6a15 UTSW 10 103,394,029 (GRCm38) critical splice donor site probably null
R8379:Slc6a15 UTSW 10 103,389,187 (GRCm38) missense probably benign 0.00
R8685:Slc6a15 UTSW 10 103,409,695 (GRCm38) missense possibly damaging 0.68
R8712:Slc6a15 UTSW 10 103,389,251 (GRCm38) missense probably damaging 1.00
R8719:Slc6a15 UTSW 10 103,404,315 (GRCm38) missense probably damaging 0.99
R8832:Slc6a15 UTSW 10 103,389,318 (GRCm38) missense probably damaging 1.00
R8940:Slc6a15 UTSW 10 103,393,496 (GRCm38) missense probably damaging 1.00
R8978:Slc6a15 UTSW 10 103,395,092 (GRCm38) nonsense probably null
R9050:Slc6a15 UTSW 10 103,416,655 (GRCm38) missense possibly damaging 0.88
R9113:Slc6a15 UTSW 10 103,400,279 (GRCm38) missense probably damaging 1.00
R9242:Slc6a15 UTSW 10 103,393,545 (GRCm38) nonsense probably null
R9493:Slc6a15 UTSW 10 103,393,416 (GRCm38) missense probably benign 0.35
R9529:Slc6a15 UTSW 10 103,404,722 (GRCm38) missense probably benign 0.14
R9532:Slc6a15 UTSW 10 103,404,472 (GRCm38) missense probably damaging 0.98
RF013:Slc6a15 UTSW 10 103,400,216 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTACTCAGGTTTATAGAAGACCTCACAGACA -3'
(R):5'- AGTAGTTCTACCTCAAAACAGACCTTCCA -3'

Sequencing Primer
(F):5'- CATGTTAGGATTTGCTCCAAGC -3'
(R):5'- AAGCTGTGCAATCACTGTTC -3'
Posted On 2013-10-16