Incidental Mutation 'R0785:Or2b7'
ID 76827
Institutional Source Beutler Lab
Gene Symbol Or2b7
Ensembl Gene ENSMUSG00000054890
Gene Name olfactory receptor family 2 subfamily B member 7
Synonyms MOR256-63, Olfr1535, Olfr1365, MOR256-36, MOR256-36, GA_x6K02T2QHY8-11688984-11689964
MMRRC Submission 038965-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R0785 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 21739210-21740190 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21739958 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 78 (V78A)
Ref Sequence ENSEMBL: ENSMUSP00000149589 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068163] [ENSMUST00000217519]
AlphaFold Q7TQU0
Predicted Effect probably benign
Transcript: ENSMUST00000068163
AA Change: V78A

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000064142
Gene: ENSMUSG00000054890
AA Change: V78A

DomainStartEndE-ValueType
Pfam:7tm_4 31 320 5.4e-46 PFAM
Pfam:7tm_1 41 302 1.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217519
AA Change: V78A

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.1%
  • 20x: 87.1%
Validation Efficiency 100% (36/36)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 G A 7: 119,893,380 (GRCm39) G1277R probably damaging Het
Adam10 A G 9: 70,675,170 (GRCm39) E593G possibly damaging Het
Adh6a T C 3: 138,034,829 (GRCm39) probably benign Het
Akap6 T A 12: 52,933,405 (GRCm39) I299N probably benign Het
Bltp1 T C 3: 37,013,483 (GRCm39) probably benign Het
Bod1l A T 5: 41,977,359 (GRCm39) N1318K probably benign Het
Ccdc121rt2 A G 5: 112,598,434 (GRCm39) D327G probably benign Het
Eif2b2 C A 12: 85,268,335 (GRCm39) T170K probably damaging Het
Ermard T A 17: 15,242,239 (GRCm39) H138Q probably damaging Het
Ern2 A T 7: 121,770,884 (GRCm39) probably null Het
Fkbp11 T C 15: 98,624,430 (GRCm39) K108R probably damaging Het
Golgb1 A G 16: 36,719,152 (GRCm39) K353E possibly damaging Het
Hipk1 G T 3: 103,661,641 (GRCm39) probably null Het
Itga4 A G 2: 79,119,649 (GRCm39) D485G possibly damaging Het
Krt1c C A 15: 101,726,356 (GRCm39) G61C unknown Het
Med12l T A 3: 59,168,253 (GRCm39) L1561Q probably damaging Het
Mtmr14 T C 6: 113,254,908 (GRCm39) probably null Het
Myorg A G 4: 41,497,539 (GRCm39) V697A probably benign Het
Naip1 A G 13: 100,559,584 (GRCm39) M1140T probably benign Het
Naip1 C T 13: 100,559,593 (GRCm39) R1137Q probably benign Het
Nav2 T A 7: 49,070,081 (GRCm39) H251Q probably benign Het
Nphp4 A G 4: 152,646,566 (GRCm39) D1366G possibly damaging Het
Or6c75 A G 10: 129,336,750 (GRCm39) probably null Het
Pde6c A C 19: 38,121,628 (GRCm39) M79L probably benign Het
Pld5 C T 1: 175,803,018 (GRCm39) probably benign Het
Polr1g G C 7: 19,091,210 (GRCm39) S299C probably benign Het
Rps6kc1 A G 1: 190,541,142 (GRCm39) V387A probably damaging Het
Tas2r136 T C 6: 132,754,890 (GRCm39) D79G probably benign Het
Tmem243 A T 5: 9,168,488 (GRCm39) K90I probably damaging Het
Topbp1 A G 9: 103,192,289 (GRCm39) H260R probably damaging Het
Trappc1 A G 11: 69,215,636 (GRCm39) probably benign Het
Vmn2r125 C A 4: 156,703,396 (GRCm39) A258D probably benign Het
Zfp300 T C X: 20,949,164 (GRCm39) Y200C possibly damaging Het
Other mutations in Or2b7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01593:Or2b7 APN 13 21,739,389 (GRCm39) missense probably damaging 0.98
IGL01866:Or2b7 APN 13 21,739,343 (GRCm39) missense probably benign 0.07
IGL02289:Or2b7 APN 13 21,739,758 (GRCm39) missense probably benign 0.02
IGL02350:Or2b7 APN 13 21,739,772 (GRCm39) missense probably damaging 1.00
IGL02357:Or2b7 APN 13 21,739,772 (GRCm39) missense probably damaging 1.00
IGL02793:Or2b7 APN 13 21,740,172 (GRCm39) missense probably damaging 1.00
IGL02875:Or2b7 APN 13 21,740,172 (GRCm39) missense probably damaging 1.00
R1773:Or2b7 UTSW 13 21,739,982 (GRCm39) missense probably damaging 1.00
R3429:Or2b7 UTSW 13 21,739,975 (GRCm39) nonsense probably null
R3430:Or2b7 UTSW 13 21,739,975 (GRCm39) nonsense probably null
R4232:Or2b7 UTSW 13 21,739,631 (GRCm39) missense probably damaging 0.98
R4883:Or2b7 UTSW 13 21,739,658 (GRCm39) missense probably benign 0.22
R5586:Or2b7 UTSW 13 21,739,266 (GRCm39) missense probably damaging 1.00
R6032:Or2b7 UTSW 13 21,740,077 (GRCm39) missense probably benign 0.01
R6032:Or2b7 UTSW 13 21,740,077 (GRCm39) missense probably benign 0.01
R6542:Or2b7 UTSW 13 21,739,677 (GRCm39) missense probably damaging 0.99
R7014:Or2b7 UTSW 13 21,740,108 (GRCm39) missense probably benign 0.02
R7579:Or2b7 UTSW 13 21,740,176 (GRCm39) missense probably benign 0.08
R7598:Or2b7 UTSW 13 21,739,358 (GRCm39) missense probably damaging 1.00
R7982:Or2b7 UTSW 13 21,740,136 (GRCm39) missense probably benign
R8239:Or2b7 UTSW 13 21,739,788 (GRCm39) missense probably benign 0.01
R8339:Or2b7 UTSW 13 21,739,996 (GRCm39) missense probably damaging 0.99
R8698:Or2b7 UTSW 13 21,739,890 (GRCm39) missense probably damaging 1.00
R8956:Or2b7 UTSW 13 21,740,169 (GRCm39) missense probably benign 0.00
R8977:Or2b7 UTSW 13 21,740,016 (GRCm39) missense possibly damaging 0.57
RF051:Or2b7 UTSW 13 21,739,693 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TGCTGTCTGTACCACAGAATTGCC -3'
(R):5'- GCTGGAAACAGCTCTCTTCTTCGC -3'

Sequencing Primer
(F):5'- CTTTATGCAAACCCTGTGAGCAAG -3'
(R):5'- CGCTATGTTGCTCATCTATTTCTTG -3'
Posted On 2013-10-16