Incidental Mutation 'R0786:Adrb3'
ID 76861
Institutional Source Beutler Lab
Gene Symbol Adrb3
Ensembl Gene ENSMUSG00000031489
Gene Name adrenergic receptor, beta 3
Synonyms Beta-3 AR, beta 3-AR, Beta-3 adrenoceptor, Adrb-3, beta3-adrenergic receptor
MMRRC Submission 038966-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.402) question?
Stock # R0786 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 27715804-27720833 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 27716880 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147871 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081438] [ENSMUST00000117565] [ENSMUST00000121838] [ENSMUST00000209299]
AlphaFold P25962
Predicted Effect probably benign
Transcript: ENSMUST00000081438
SMART Domains Protein: ENSMUSP00000080162
Gene: ENSMUSG00000031489

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 43 240 1.1e-6 PFAM
Pfam:7TM_GPCR_Srsx 45 357 2.3e-14 PFAM
Pfam:7tm_1 51 343 9.3e-79 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000117565
AA Change: Y403C
SMART Domains Protein: ENSMUSP00000113732
Gene: ENSMUSG00000031489
AA Change: Y403C

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 43 240 1.8e-6 PFAM
Pfam:7TM_GPCR_Srsx 45 357 2.4e-14 PFAM
Pfam:7tm_1 51 343 4.9e-70 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000121838
SMART Domains Protein: ENSMUSP00000113006
Gene: ENSMUSG00000031489

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 43 240 1.1e-6 PFAM
Pfam:7TM_GPCR_Srsx 45 357 2.3e-14 PFAM
Pfam:7tm_1 51 343 9.3e-79 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209299
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209447
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209685
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211346
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211002
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.6%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]
PHENOTYPE: Homozygotes for targeted null mutations develop greater adiposity, especially on a high-fat diet, and are unresponsive to the beta3-adrenergic receptor agonist, CL316,243. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atg2b T C 12: 105,602,767 (GRCm39) H1592R probably benign Het
Bpifb1 C T 2: 154,044,581 (GRCm39) A16V probably benign Het
Cep57 T A 9: 13,721,166 (GRCm39) Y271F probably damaging Het
Cfap54 A T 10: 92,803,397 (GRCm39) N1548K possibly damaging Het
Chrna6 A T 8: 27,898,408 (GRCm39) D103E probably benign Het
Clec12b T C 6: 129,357,651 (GRCm39) N69S probably benign Het
Col27a1 T C 4: 63,209,815 (GRCm39) probably null Het
Cwh43 T A 5: 73,565,526 (GRCm39) Y30* probably null Het
Dnai7 A G 6: 145,127,483 (GRCm39) probably null Het
Dsg4 T C 18: 20,582,429 (GRCm39) probably null Het
Efna3 T C 3: 89,223,880 (GRCm39) N103S probably damaging Het
Efr3a A G 15: 65,725,400 (GRCm39) D532G possibly damaging Het
Fam227a A T 15: 79,510,469 (GRCm39) V395D probably benign Het
Fes T A 7: 80,036,668 (GRCm39) D93V probably damaging Het
Gbp3 T A 3: 142,276,732 (GRCm39) M510K possibly damaging Het
Gpr12 A T 5: 146,520,314 (GRCm39) S44T probably damaging Het
Gpr179 T C 11: 97,234,100 (GRCm39) N583S probably damaging Het
Hipk1 T C 3: 103,651,620 (GRCm39) T1093A probably benign Het
Hspb1 T C 5: 135,918,097 (GRCm39) L148P probably damaging Het
Kirrel3 A G 9: 34,946,161 (GRCm39) N640S probably damaging Het
Mak G T 13: 41,199,545 (GRCm39) Q365K probably benign Het
Melk A G 4: 44,303,649 (GRCm39) Y14C unknown Het
Myh7 T C 14: 55,230,330 (GRCm39) M1V probably null Het
Nsmf A G 2: 24,950,522 (GRCm39) Y330C probably damaging Het
Parp14 A G 16: 35,661,172 (GRCm39) F1592S possibly damaging Het
Pnpla6 A T 8: 3,573,317 (GRCm39) I394F probably benign Het
Ppl T C 16: 4,906,918 (GRCm39) R1126G probably damaging Het
Prss8 C T 7: 127,525,646 (GRCm39) R291Q probably benign Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rasgrp1 G T 2: 117,130,980 (GRCm39) D155E probably benign Het
Recql5 T C 11: 115,786,628 (GRCm39) I563V probably benign Het
Rhbg C T 3: 88,151,875 (GRCm39) M394I probably benign Het
Rnf130 A G 11: 49,978,264 (GRCm39) D275G probably damaging Het
Smg9 T C 7: 24,120,289 (GRCm39) F421S probably benign Het
Tgm2 T C 2: 157,966,301 (GRCm39) E451G probably damaging Het
Tle1 T A 4: 72,117,598 (GRCm39) T21S probably damaging Het
Tmc5 T C 7: 118,226,433 (GRCm39) I266T possibly damaging Het
Tmigd3 T A 3: 105,824,318 (GRCm39) C96S probably damaging Het
Trdn A T 10: 33,181,077 (GRCm39) T361S probably benign Het
Vgll3 A T 16: 65,657,568 (GRCm39) Q261L probably benign Het
Vmn2r104 A T 17: 20,262,987 (GRCm39) I158K probably benign Het
Zfp964 A G 8: 70,116,731 (GRCm39) K444E possibly damaging Het
Other mutations in Adrb3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0639:Adrb3 UTSW 8 27,718,293 (GRCm39) missense probably damaging 0.97
R1370:Adrb3 UTSW 8 27,717,798 (GRCm39) splice site probably null
R1449:Adrb3 UTSW 8 27,717,415 (GRCm39) missense probably damaging 1.00
R1874:Adrb3 UTSW 8 27,717,591 (GRCm39) missense probably damaging 1.00
R3426:Adrb3 UTSW 8 27,718,209 (GRCm39) missense probably damaging 1.00
R3428:Adrb3 UTSW 8 27,718,209 (GRCm39) missense probably damaging 1.00
R4941:Adrb3 UTSW 8 27,717,450 (GRCm39) missense probably damaging 1.00
R4989:Adrb3 UTSW 8 27,717,798 (GRCm39) missense probably damaging 1.00
R4994:Adrb3 UTSW 8 27,717,855 (GRCm39) splice site probably null
R5133:Adrb3 UTSW 8 27,717,798 (GRCm39) missense probably damaging 1.00
R5134:Adrb3 UTSW 8 27,717,798 (GRCm39) missense probably damaging 1.00
R5162:Adrb3 UTSW 8 27,717,348 (GRCm39) missense probably benign 0.25
R5342:Adrb3 UTSW 8 27,716,809 (GRCm39) nonsense probably null
R5656:Adrb3 UTSW 8 27,717,405 (GRCm39) missense probably damaging 0.99
R8159:Adrb3 UTSW 8 27,718,099 (GRCm39) missense probably benign 0.06
R9020:Adrb3 UTSW 8 27,717,947 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATCCCATAGGGTCCATCCTGCAC -3'
(R):5'- CCAATCCCTGGGTCTGAAGCAAAAG -3'

Sequencing Primer
(F):5'- AGTCCCACCCTATAGTTCTAATCCAG -3'
(R):5'- GGTCTGAAGCAAAAGGGAGG -3'
Posted On 2013-10-16