Mutagenetix > Incidental Mutation

Incidental Mutation 'R0786:Zfp964'

76863

Institutional Source

Beutler Lab

Gene Symbol

Zfp964

Ensembl Gene

ENSMUSG00000091764

Gene Name

zinc finger protein 964

Synonyms

Gm7187

MMRRC Submission

038966-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R0786 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

70107129-70119632 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 70116731 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamic Acid at position 444 (K444E)

Ref Sequence

ENSEMBL: ENSMUSP00000145354 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169125] [ENSMUST00000204285]

AlphaFold

B2RR88

Predicted Effect

possibly damaging
Transcript: ENSMUST00000169125
AA Change: K443E

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000129822
Gene: ENSMUSG00000091764
AA Change: K443E

Domain	Start	End	E-Value	Type
KRAB	3	56	5.24e-18	SMART
ZnF_C2H2	216	238	4.54e-4	SMART
ZnF_C2H2	244	266	3.58e-2	SMART
ZnF_C2H2	272	294	2.2e-2	SMART
ZnF_C2H2	300	322	5.5e-3	SMART
ZnF_C2H2	328	350	8.22e-2	SMART
ZnF_C2H2	356	378	2.05e-2	SMART
ZnF_C2H2	384	406	6.32e-3	SMART
ZnF_C2H2	412	434	5.42e-2	SMART
ZnF_C2H2	440	462	1.28e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204062

Predicted Effect

possibly damaging
Transcript: ENSMUST00000204285
AA Change: K444E

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000145354
Gene: ENSMUSG00000091764
AA Change: K444E

Domain	Start	End	E-Value	Type
KRAB	4	57	5.24e-18	SMART
ZnF_C2H2	217	239	4.54e-4	SMART
ZnF_C2H2	245	267	3.58e-2	SMART
ZnF_C2H2	273	295	2.2e-2	SMART
ZnF_C2H2	301	323	5.5e-3	SMART
ZnF_C2H2	329	351	8.22e-2	SMART
ZnF_C2H2	357	379	2.05e-2	SMART
ZnF_C2H2	385	407	6.32e-3	SMART
ZnF_C2H2	413	435	5.42e-2	SMART
ZnF_C2H2	441	463	1.28e-3	SMART

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 96.6%
20x: 92.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adrb3	T	C	8: 27,716,880 (GRCm39)		probably benign	Het
Atg2b	T	C	12: 105,602,767 (GRCm39)	H1592R	probably benign	Het
Bpifb1	C	T	2: 154,044,581 (GRCm39)	A16V	probably benign	Het
Cep57	T	A	9: 13,721,166 (GRCm39)	Y271F	probably damaging	Het
Cfap54	A	T	10: 92,803,397 (GRCm39)	N1548K	possibly damaging	Het
Chrna6	A	T	8: 27,898,408 (GRCm39)	D103E	probably benign	Het
Clec12b	T	C	6: 129,357,651 (GRCm39)	N69S	probably benign	Het
Col27a1	T	C	4: 63,209,815 (GRCm39)		probably null	Het
Cwh43	T	A	5: 73,565,526 (GRCm39)	Y30*	probably null	Het
Dnai7	A	G	6: 145,127,483 (GRCm39)		probably null	Het
Dsg4	T	C	18: 20,582,429 (GRCm39)		probably null	Het
Efna3	T	C	3: 89,223,880 (GRCm39)	N103S	probably damaging	Het
Efr3a	A	G	15: 65,725,400 (GRCm39)	D532G	possibly damaging	Het
Fam227a	A	T	15: 79,510,469 (GRCm39)	V395D	probably benign	Het
Fes	T	A	7: 80,036,668 (GRCm39)	D93V	probably damaging	Het
Gbp3	T	A	3: 142,276,732 (GRCm39)	M510K	possibly damaging	Het
Gpr12	A	T	5: 146,520,314 (GRCm39)	S44T	probably damaging	Het
Gpr179	T	C	11: 97,234,100 (GRCm39)	N583S	probably damaging	Het
Hipk1	T	C	3: 103,651,620 (GRCm39)	T1093A	probably benign	Het
Hspb1	T	C	5: 135,918,097 (GRCm39)	L148P	probably damaging	Het
Kirrel3	A	G	9: 34,946,161 (GRCm39)	N640S	probably damaging	Het
Mak	G	T	13: 41,199,545 (GRCm39)	Q365K	probably benign	Het
Melk	A	G	4: 44,303,649 (GRCm39)	Y14C	unknown	Het
Myh7	T	C	14: 55,230,330 (GRCm39)	M1V	probably null	Het
Nsmf	A	G	2: 24,950,522 (GRCm39)	Y330C	probably damaging	Het
Parp14	A	G	16: 35,661,172 (GRCm39)	F1592S	possibly damaging	Het
Pnpla6	A	T	8: 3,573,317 (GRCm39)	I394F	probably benign	Het
Ppl	T	C	16: 4,906,918 (GRCm39)	R1126G	probably damaging	Het
Prss8	C	T	7: 127,525,646 (GRCm39)	R291Q	probably benign	Het
Ptpro	T	A	6: 137,420,592 (GRCm39)	V1007D	probably damaging	Het
Rasgrp1	G	T	2: 117,130,980 (GRCm39)	D155E	probably benign	Het
Recql5	T	C	11: 115,786,628 (GRCm39)	I563V	probably benign	Het
Rhbg	C	T	3: 88,151,875 (GRCm39)	M394I	probably benign	Het
Rnf130	A	G	11: 49,978,264 (GRCm39)	D275G	probably damaging	Het
Smg9	T	C	7: 24,120,289 (GRCm39)	F421S	probably benign	Het
Tgm2	T	C	2: 157,966,301 (GRCm39)	E451G	probably damaging	Het
Tle1	T	A	4: 72,117,598 (GRCm39)	T21S	probably damaging	Het
Tmc5	T	C	7: 118,226,433 (GRCm39)	I266T	possibly damaging	Het
Tmigd3	T	A	3: 105,824,318 (GRCm39)	C96S	probably damaging	Het
Trdn	A	T	10: 33,181,077 (GRCm39)	T361S	probably benign	Het
Vgll3	A	T	16: 65,657,568 (GRCm39)	Q261L	probably benign	Het
Vmn2r104	A	T	17: 20,262,987 (GRCm39)	I158K	probably benign	Het

Other mutations in Zfp964

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00580:Zfp964	APN	8	70,112,043 (GRCm39)	splice site	probably null
R0506:Zfp964	UTSW	8	70,116,587 (GRCm39)	missense	unknown
R0740:Zfp964	UTSW	8	70,115,828 (GRCm39)	missense	probably damaging	0.98
R1158:Zfp964	UTSW	8	70,116,503 (GRCm39)	missense	unknown
R1204:Zfp964	UTSW	8	70,116,668 (GRCm39)	missense	probably benign	0.08
R1413:Zfp964	UTSW	8	70,115,720 (GRCm39)	missense	unknown
R1562:Zfp964	UTSW	8	70,115,654 (GRCm39)	missense	probably benign
R1663:Zfp964	UTSW	8	70,116,733 (GRCm39)	splice site	probably null
R1693:Zfp964	UTSW	8	70,116,800 (GRCm39)	missense	possibly damaging	0.55
R2029:Zfp964	UTSW	8	70,116,567 (GRCm39)	missense	unknown
R2847:Zfp964	UTSW	8	70,116,504 (GRCm39)	missense	unknown
R2849:Zfp964	UTSW	8	70,116,504 (GRCm39)	missense	unknown
R4111:Zfp964	UTSW	8	70,116,754 (GRCm39)	missense	probably benign	0.18
R4792:Zfp964	UTSW	8	70,116,665 (GRCm39)	missense	probably benign	0.18
R4907:Zfp964	UTSW	8	70,115,972 (GRCm39)	missense	possibly damaging	0.86
R4938:Zfp964	UTSW	8	70,116,758 (GRCm39)	missense	possibly damaging	0.64
R5688:Zfp964	UTSW	8	70,116,766 (GRCm39)	missense	probably benign	0.03
R5905:Zfp964	UTSW	8	70,116,563 (GRCm39)	missense	unknown
R6009:Zfp964	UTSW	8	70,116,106 (GRCm39)	missense	possibly damaging	0.71
R6021:Zfp964	UTSW	8	70,115,742 (GRCm39)	missense	unknown
R6028:Zfp964	UTSW	8	70,116,563 (GRCm39)	missense	unknown
R6374:Zfp964	UTSW	8	70,111,994 (GRCm39)	missense	possibly damaging	0.93
R6583:Zfp964	UTSW	8	70,115,633 (GRCm39)	missense	probably damaging	0.98
R7730:Zfp964	UTSW	8	70,116,360 (GRCm39)	missense	possibly damaging	0.85
R8263:Zfp964	UTSW	8	70,116,345 (GRCm39)	missense	possibly damaging	0.92
R8309:Zfp964	UTSW	8	70,115,924 (GRCm39)	missense	possibly damaging	0.53
R8889:Zfp964	UTSW	8	70,116,405 (GRCm39)	missense	probably damaging	1.00
R8892:Zfp964	UTSW	8	70,116,405 (GRCm39)	missense	probably damaging	1.00
R9133:Zfp964	UTSW	8	70,115,783 (GRCm39)	missense	probably benign	0.00
R9185:Zfp964	UTSW	8	70,115,873 (GRCm39)	missense	possibly damaging	0.53

Predicted Primers

Posted On

2013-10-16