Incidental Mutation 'R0771:Lgalsl2'
ID |
76950 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Lgalsl2
|
Ensembl Gene |
ENSMUSG00000048398 |
Gene Name |
galectin like 2 |
Synonyms |
Gm5065 |
MMRRC Submission |
038951-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.198)
|
Stock # |
R0771 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
5353541-5363681 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 5362822 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Glycine
at position 151
(D151G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000146867
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000056639]
[ENSMUST00000207531]
|
AlphaFold |
Q7TPX9 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000056639
AA Change: D151G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000055799 Gene: ENSMUSG00000048398 AA Change: D151G
Domain | Start | End | E-Value | Type |
GLECT
|
31 |
165 |
1.56e-15 |
SMART |
Gal-bind_lectin
|
37 |
165 |
2.51e-43 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000207531
AA Change: D151G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.2%
- 20x: 94.4%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 25 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abr |
T |
C |
11: 76,346,509 (GRCm39) |
E434G |
probably damaging |
Het |
Adam19 |
G |
A |
11: 46,012,280 (GRCm39) |
V259I |
possibly damaging |
Het |
Adam5 |
A |
G |
8: 25,276,315 (GRCm39) |
S451P |
probably benign |
Het |
Chd6 |
G |
A |
2: 160,861,500 (GRCm39) |
L516F |
probably damaging |
Het |
Elovl4 |
A |
G |
9: 83,667,168 (GRCm39) |
V154A |
possibly damaging |
Het |
Gadl1 |
G |
A |
9: 115,773,300 (GRCm39) |
R114Q |
probably damaging |
Het |
Ipo13 |
T |
C |
4: 117,751,843 (GRCm39) |
N936S |
possibly damaging |
Het |
Kcnd2 |
T |
A |
6: 21,216,441 (GRCm39) |
S48R |
probably damaging |
Het |
Lim2 |
C |
A |
7: 43,080,127 (GRCm39) |
A38E |
possibly damaging |
Het |
Lrp2 |
A |
T |
2: 69,338,334 (GRCm39) |
D1177E |
probably damaging |
Het |
Mdh1 |
C |
T |
11: 21,507,550 (GRCm39) |
V300I |
probably benign |
Het |
Mfsd4b4 |
T |
C |
10: 39,768,407 (GRCm39) |
T275A |
probably benign |
Het |
Myo10 |
A |
G |
15: 25,778,264 (GRCm39) |
Y114C |
probably damaging |
Het |
Ncapg2 |
T |
A |
12: 116,376,779 (GRCm39) |
C122* |
probably null |
Het |
Nod1 |
T |
G |
6: 54,921,254 (GRCm39) |
S355R |
probably damaging |
Het |
Or52x1 |
T |
A |
7: 104,853,368 (GRCm39) |
M61L |
possibly damaging |
Het |
Or5ap2 |
A |
T |
2: 85,680,338 (GRCm39) |
I181F |
possibly damaging |
Het |
Pcsk1 |
A |
T |
13: 75,280,281 (GRCm39) |
E702V |
probably benign |
Het |
Ptpn21 |
T |
C |
12: 98,655,339 (GRCm39) |
T543A |
probably damaging |
Het |
Ranbp9 |
T |
C |
13: 43,615,249 (GRCm39) |
I190V |
possibly damaging |
Het |
Sirpd |
T |
A |
3: 15,385,506 (GRCm39) |
Q132L |
probably benign |
Het |
Slc1a4 |
C |
T |
11: 20,256,467 (GRCm39) |
V455M |
probably damaging |
Het |
Srbd1 |
T |
A |
17: 86,437,682 (GRCm39) |
E220D |
probably benign |
Het |
Thsd7a |
A |
G |
6: 12,327,576 (GRCm39) |
V1432A |
probably benign |
Het |
Zfp61 |
T |
C |
7: 23,992,779 (GRCm39) |
R71G |
probably benign |
Het |
|
Other mutations in Lgalsl2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02060:Lgalsl2
|
APN |
7 |
5,362,563 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02147:Lgalsl2
|
APN |
7 |
5,362,732 (GRCm39) |
missense |
probably damaging |
1.00 |
R0906:Lgalsl2
|
UTSW |
7 |
5,362,828 (GRCm39) |
missense |
probably damaging |
0.99 |
R2018:Lgalsl2
|
UTSW |
7 |
5,362,573 (GRCm39) |
missense |
probably benign |
0.18 |
R2258:Lgalsl2
|
UTSW |
7 |
5,362,401 (GRCm39) |
missense |
probably benign |
|
R2519:Lgalsl2
|
UTSW |
7 |
5,362,833 (GRCm39) |
missense |
probably damaging |
1.00 |
R2865:Lgalsl2
|
UTSW |
7 |
5,362,668 (GRCm39) |
missense |
probably benign |
0.25 |
R5893:Lgalsl2
|
UTSW |
7 |
5,362,623 (GRCm39) |
missense |
probably benign |
0.00 |
R7485:Lgalsl2
|
UTSW |
7 |
5,362,440 (GRCm39) |
missense |
probably benign |
0.39 |
R7716:Lgalsl2
|
UTSW |
7 |
5,362,819 (GRCm39) |
missense |
possibly damaging |
0.56 |
R7836:Lgalsl2
|
UTSW |
7 |
5,362,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R7898:Lgalsl2
|
UTSW |
7 |
5,362,441 (GRCm39) |
missense |
probably benign |
0.22 |
R8192:Lgalsl2
|
UTSW |
7 |
5,362,595 (GRCm39) |
missense |
possibly damaging |
0.77 |
R9324:Lgalsl2
|
UTSW |
7 |
5,362,527 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
Predicted Primers |
PCR Primer
(F):5'- ACTCTGAAGATCCTCCTGCCGATG -3'
(R):5'- AGCTTTCTTCTTCTGGGCAAACCAC -3'
Sequencing Primer
(F):5'- TTGTGTTCACAAACCAGCAGG -3'
(R):5'- CCACAGATGAAGTTGTCATTCCAG -3'
|
Posted On |
2013-10-16 |