Incidental Mutation 'R0771:Lgalsl2'
ID 76950
Institutional Source Beutler Lab
Gene Symbol Lgalsl2
Ensembl Gene ENSMUSG00000048398
Gene Name galectin like 2
Synonyms Gm5065
MMRRC Submission 038951-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.198) question?
Stock # R0771 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 5353541-5363681 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 5362822 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 151 (D151G)
Ref Sequence ENSEMBL: ENSMUSP00000146867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056639] [ENSMUST00000207531]
AlphaFold Q7TPX9
Predicted Effect probably damaging
Transcript: ENSMUST00000056639
AA Change: D151G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000055799
Gene: ENSMUSG00000048398
AA Change: D151G

DomainStartEndE-ValueType
GLECT 31 165 1.56e-15 SMART
Gal-bind_lectin 37 165 2.51e-43 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000207531
AA Change: D151G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.2%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abr T C 11: 76,346,509 (GRCm39) E434G probably damaging Het
Adam19 G A 11: 46,012,280 (GRCm39) V259I possibly damaging Het
Adam5 A G 8: 25,276,315 (GRCm39) S451P probably benign Het
Chd6 G A 2: 160,861,500 (GRCm39) L516F probably damaging Het
Elovl4 A G 9: 83,667,168 (GRCm39) V154A possibly damaging Het
Gadl1 G A 9: 115,773,300 (GRCm39) R114Q probably damaging Het
Ipo13 T C 4: 117,751,843 (GRCm39) N936S possibly damaging Het
Kcnd2 T A 6: 21,216,441 (GRCm39) S48R probably damaging Het
Lim2 C A 7: 43,080,127 (GRCm39) A38E possibly damaging Het
Lrp2 A T 2: 69,338,334 (GRCm39) D1177E probably damaging Het
Mdh1 C T 11: 21,507,550 (GRCm39) V300I probably benign Het
Mfsd4b4 T C 10: 39,768,407 (GRCm39) T275A probably benign Het
Myo10 A G 15: 25,778,264 (GRCm39) Y114C probably damaging Het
Ncapg2 T A 12: 116,376,779 (GRCm39) C122* probably null Het
Nod1 T G 6: 54,921,254 (GRCm39) S355R probably damaging Het
Or52x1 T A 7: 104,853,368 (GRCm39) M61L possibly damaging Het
Or5ap2 A T 2: 85,680,338 (GRCm39) I181F possibly damaging Het
Pcsk1 A T 13: 75,280,281 (GRCm39) E702V probably benign Het
Ptpn21 T C 12: 98,655,339 (GRCm39) T543A probably damaging Het
Ranbp9 T C 13: 43,615,249 (GRCm39) I190V possibly damaging Het
Sirpd T A 3: 15,385,506 (GRCm39) Q132L probably benign Het
Slc1a4 C T 11: 20,256,467 (GRCm39) V455M probably damaging Het
Srbd1 T A 17: 86,437,682 (GRCm39) E220D probably benign Het
Thsd7a A G 6: 12,327,576 (GRCm39) V1432A probably benign Het
Zfp61 T C 7: 23,992,779 (GRCm39) R71G probably benign Het
Other mutations in Lgalsl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02060:Lgalsl2 APN 7 5,362,563 (GRCm39) missense probably damaging 0.99
IGL02147:Lgalsl2 APN 7 5,362,732 (GRCm39) missense probably damaging 1.00
R0906:Lgalsl2 UTSW 7 5,362,828 (GRCm39) missense probably damaging 0.99
R2018:Lgalsl2 UTSW 7 5,362,573 (GRCm39) missense probably benign 0.18
R2258:Lgalsl2 UTSW 7 5,362,401 (GRCm39) missense probably benign
R2519:Lgalsl2 UTSW 7 5,362,833 (GRCm39) missense probably damaging 1.00
R2865:Lgalsl2 UTSW 7 5,362,668 (GRCm39) missense probably benign 0.25
R5893:Lgalsl2 UTSW 7 5,362,623 (GRCm39) missense probably benign 0.00
R7485:Lgalsl2 UTSW 7 5,362,440 (GRCm39) missense probably benign 0.39
R7716:Lgalsl2 UTSW 7 5,362,819 (GRCm39) missense possibly damaging 0.56
R7836:Lgalsl2 UTSW 7 5,362,507 (GRCm39) missense probably damaging 1.00
R7898:Lgalsl2 UTSW 7 5,362,441 (GRCm39) missense probably benign 0.22
R8192:Lgalsl2 UTSW 7 5,362,595 (GRCm39) missense possibly damaging 0.77
R9324:Lgalsl2 UTSW 7 5,362,527 (GRCm39) missense possibly damaging 0.61
Predicted Primers PCR Primer
(F):5'- ACTCTGAAGATCCTCCTGCCGATG -3'
(R):5'- AGCTTTCTTCTTCTGGGCAAACCAC -3'

Sequencing Primer
(F):5'- TTGTGTTCACAAACCAGCAGG -3'
(R):5'- CCACAGATGAAGTTGTCATTCCAG -3'
Posted On 2013-10-16