Incidental Mutation 'R0847:Tmem167b'
ID 76998
Institutional Source Beutler Lab
Gene Symbol Tmem167b
Ensembl Gene ENSMUSG00000068732
Gene Name transmembrane protein 167B
Synonyms 2010200O16Rik
MMRRC Submission 039026-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.275) question?
Stock # R0847 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 108463741-108469782 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 108467537 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 46 (G46R)
Ref Sequence ENSEMBL: ENSMUSP00000102233 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090546] [ENSMUST00000106622]
AlphaFold Q80X45
Predicted Effect silent
Transcript: ENSMUST00000090546
SMART Domains Protein: ENSMUSP00000088035
Gene: ENSMUSG00000068732

DomainStartEndE-ValueType
Pfam:DUF1242 10 46 7.6e-14 PFAM
transmembrane domain 50 72 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106622
AA Change: G46R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000102233
Gene: ENSMUSG00000068732
AA Change: G46R

DomainStartEndE-ValueType
signal peptide 1 39 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199996
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b T C 5: 8,895,764 (GRCm39) I899T probably damaging Het
Ahnak C T 19: 8,983,797 (GRCm39) Q1694* probably null Het
Cblc A T 7: 19,524,459 (GRCm39) Y260* probably null Het
Ccn4 T G 15: 66,791,124 (GRCm39) C309G probably damaging Het
Ceacam5 A G 7: 17,491,762 (GRCm39) T711A possibly damaging Het
Cep63 A G 9: 102,465,957 (GRCm39) S690P probably benign Het
Chia1 A T 3: 106,039,253 (GRCm39) I448F probably benign Het
Dmxl2 A T 9: 54,313,112 (GRCm39) F1712I probably damaging Het
Ecpas G A 4: 58,841,439 (GRCm39) T645I probably benign Het
Exosc3 A G 4: 45,319,695 (GRCm39) V109A probably damaging Het
Fxyd7 A G 7: 30,744,029 (GRCm39) C60R probably damaging Het
Gm17349 C A 15: 99,600,289 (GRCm39) probably benign Het
Gpn2 A G 4: 133,315,906 (GRCm39) N199D probably benign Het
Ints12 C T 3: 132,814,603 (GRCm39) T270M possibly damaging Het
Kdm4a C T 4: 118,021,695 (GRCm39) E266K probably damaging Het
Kremen2 G T 17: 23,963,634 (GRCm39) T50N probably damaging Het
Macf1 A T 4: 123,293,159 (GRCm39) D1249E probably benign Het
Mdga2 T A 12: 66,769,854 (GRCm39) K146N probably damaging Het
Med20 G A 17: 47,922,618 (GRCm39) probably null Het
Myo18b T C 5: 113,022,354 (GRCm39) probably benign Het
Nav3 T A 10: 109,739,718 (GRCm39) T84S possibly damaging Het
Olfm2 A G 9: 20,579,953 (GRCm39) V266A probably damaging Het
Or5b101 A T 19: 13,005,095 (GRCm39) Y199* probably null Het
Or5b123 C T 19: 13,596,915 (GRCm39) H87Y probably benign Het
Or6c69b T A 10: 129,627,327 (GRCm39) I44F probably damaging Het
Pthlh A T 6: 147,164,766 (GRCm39) probably null Het
Rpap3 C T 15: 97,601,082 (GRCm39) probably null Het
Rprd2 A G 3: 95,672,725 (GRCm39) S893P probably benign Het
Sacm1l G A 9: 123,377,927 (GRCm39) G69D probably damaging Het
Slc27a4 T C 2: 29,701,261 (GRCm39) S351P probably benign Het
Sobp C G 10: 42,898,415 (GRCm39) R390P probably damaging Het
Spata7 T A 12: 98,614,689 (GRCm39) M107K possibly damaging Het
Sri G A 5: 8,113,755 (GRCm39) probably null Het
Stab2 T C 10: 86,805,735 (GRCm39) I204V probably benign Het
Synm T C 7: 67,384,804 (GRCm39) I511V probably damaging Het
Tbr1 T C 2: 61,635,373 (GRCm39) S108P probably benign Het
Tln1 A G 4: 43,555,333 (GRCm39) F197S probably damaging Het
Tmprss11g T C 5: 86,638,585 (GRCm39) K301R probably benign Het
Tnfrsf21 C T 17: 43,349,104 (GRCm39) H239Y probably benign Het
Trpm2 C T 10: 77,765,122 (GRCm39) V960M possibly damaging Het
Ube3a G A 7: 58,926,334 (GRCm39) D371N possibly damaging Het
Vmn2r57 A T 7: 41,078,225 (GRCm39) F78I probably benign Het
Other mutations in Tmem167b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01542:Tmem167b APN 3 108,466,222 (GRCm39) missense possibly damaging 0.82
R5310:Tmem167b UTSW 3 108,469,415 (GRCm39) intron probably benign
R5524:Tmem167b UTSW 3 108,467,569 (GRCm39) missense possibly damaging 0.84
R5808:Tmem167b UTSW 3 108,467,559 (GRCm39) missense probably benign 0.27
R6093:Tmem167b UTSW 3 108,469,439 (GRCm39) start codon destroyed probably null
R6358:Tmem167b UTSW 3 108,466,211 (GRCm39) missense possibly damaging 0.94
R7716:Tmem167b UTSW 3 108,466,213 (GRCm39) missense probably damaging 1.00
R8922:Tmem167b UTSW 3 108,467,541 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TGAGTCCAAATATCACCCTGGTCCTAC -3'
(R):5'- CCAAGATCATGGACCCTTCCTGTTTAC -3'

Sequencing Primer
(F):5'- AGATCTGCATCTGTTGGTAAAGC -3'
(R):5'- TTGGCCCTGCCGTTGAG -3'
Posted On 2013-10-16