Mutagenetix > Incidental Mutation

Incidental Mutation 'R0849:Gm2381'

77067

Institutional Source

Beutler Lab

Gene Symbol

Gm2381

Ensembl Gene

ENSMUSG00000092225

Gene Name

predicted gene 2381

Synonyms

MMRRC Submission

039028-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.178) question?

Stock #

R0849 (G1)

Quality Score

223

Status

Not validated

Chromosome

Chromosomal Location

42466253-42516658 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 42469372 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 251 (Q251*)

Ref Sequence

ENSEMBL: ENSMUSP00000133949 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000174558]

AlphaFold

G3UY53

Predicted Effect

probably null
Transcript: ENSMUST00000174558
AA Change: Q251*

SMART Domains

Protein: ENSMUSP00000133949
Gene: ENSMUSG00000092225
AA Change: Q251*

Domain	Start	End	E-Value	Type
Blast:KRAB	1	34	1e-15	BLAST
ZnF_C2H2	99	121	5.5e-3	SMART
ZnF_C2H2	127	149	5.9e-3	SMART
ZnF_C2H2	155	177	7.37e-4	SMART
ZnF_C2H2	183	205	2.75e-3	SMART
ZnF_C2H2	211	233	3.69e-4	SMART
ZnF_C2H2	239	261	3.34e-2	SMART
ZnF_C2H2	267	289	1.58e-3	SMART

Coding Region Coverage

1x: 99.3%
3x: 98.5%
10x: 96.5%
20x: 92.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap5	T	C	12: 52,566,406 (GRCm39)	F1126L	probably benign	Het
Arhgef11	G	T	3: 87,643,203 (GRCm39)	A1472S	probably benign	Het
Armc9	G	A	1: 86,184,992 (GRCm39)	R681K	probably benign	Het
Atxn2	T	A	5: 121,885,484 (GRCm39)		probably null	Het
B3gnt6	C	A	7: 97,843,950 (GRCm39)	L3F	probably benign	Het
Cand2	A	G	6: 115,769,352 (GRCm39)	T721A	probably damaging	Het
Cntn2	A	T	1: 132,450,124 (GRCm39)	M590K	probably benign	Het
Cntn4	A	T	6: 106,644,418 (GRCm39)	D622V	probably damaging	Het
Des	T	G	1: 75,337,272 (GRCm39)	S71A	probably benign	Het
Dnah5	C	A	15: 28,263,745 (GRCm39)	R827S	probably damaging	Het
Dstn	G	A	2: 143,780,455 (GRCm39)	G52S	probably benign	Het
Eln	T	A	5: 134,736,835 (GRCm39)	R704*	probably null	Het
Fezf2	T	A	14: 12,342,607 (GRCm38)	K419N	probably damaging	Het
Grin3a	G	A	4: 49,665,501 (GRCm39)	R1045*	probably null	Het
Herc2	T	A	7: 55,856,326 (GRCm39)	H3921Q	probably damaging	Het
Hs3st2	A	G	7: 121,100,255 (GRCm39)	E367G	possibly damaging	Het
Hydin	G	A	8: 111,325,616 (GRCm39)	R4675H	probably damaging	Het
Inhca	A	C	9: 103,140,256 (GRCm39)	Y488D	possibly damaging	Het
Irf2bp1	T	C	7: 18,738,659 (GRCm39)	S100P	possibly damaging	Het
Itga10	A	G	3: 96,559,846 (GRCm39)	I500M	possibly damaging	Het
Kcnt2	T	C	1: 140,435,500 (GRCm39)	V496A	probably damaging	Het
Mansc1	T	C	6: 134,587,670 (GRCm39)	D169G	probably benign	Het
Mdn1	T	A	4: 32,741,835 (GRCm39)	S3869T	probably damaging	Het
Mrgprb4	G	A	7: 47,848,868 (GRCm39)	T20I	probably benign	Het
Nek4	A	G	14: 30,679,253 (GRCm39)	E198G	probably damaging	Het
Or12e8	G	T	2: 87,188,609 (GRCm39)	V274L	probably benign	Het
Or2y10	G	A	11: 49,455,129 (GRCm39)	C127Y	probably damaging	Het
Or5w11	C	A	2: 87,459,626 (GRCm39)	T273K	possibly damaging	Het
Ppfia4	A	T	1: 134,247,110 (GRCm39)	F537I	probably benign	Het
Rarb	A	G	14: 16,434,293 (GRCm38)	V295A	probably damaging	Het
Ryr1	A	G	7: 28,740,104 (GRCm39)	S3941P	probably damaging	Het
Scnn1b	A	G	7: 121,511,698 (GRCm39)	N370S	probably damaging	Het
Stard9	C	A	2: 120,504,117 (GRCm39)	S221R	probably damaging	Het
Sv2c	C	T	13: 96,126,319 (GRCm39)	G311D	probably damaging	Het
Tas2r109	T	C	6: 132,957,856 (GRCm39)	I25V	probably benign	Het
Tbcel	A	C	9: 42,348,453 (GRCm39)	I305S	probably damaging	Het
Tmem35b	A	G	4: 127,019,990 (GRCm39)		probably null	Het
Tmem38b	T	C	4: 53,840,765 (GRCm39)	L60S	probably damaging	Het
Tmtc4	A	G	14: 123,182,966 (GRCm39)	I244T	possibly damaging	Het
Usp9y	C	A	Y: 1,394,002 (GRCm39)	C576F	probably damaging	Het
Vcan	A	T	13: 89,853,072 (GRCm39)	N629K	possibly damaging	Het
Vmn2r22	T	C	6: 123,614,363 (GRCm39)	Y409C	probably damaging	Het
Vmn2r-ps158	A	G	7: 42,674,142 (GRCm39)	Y400C	probably damaging	Het

Other mutations in Gm2381

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02309:Gm2381	APN	7	42,472,033 (GRCm39)	splice site	probably benign
R0266:Gm2381	UTSW	7	42,469,372 (GRCm39)	nonsense	probably null
R0617:Gm2381	UTSW	7	42,469,402 (GRCm39)	missense	probably damaging	1.00
R0650:Gm2381	UTSW	7	42,469,504 (GRCm39)	missense	probably damaging	0.98
R1340:Gm2381	UTSW	7	42,469,828 (GRCm39)	missense	possibly damaging	0.76
R1549:Gm2381	UTSW	7	42,471,825 (GRCm39)	missense	probably benign	0.09
R1702:Gm2381	UTSW	7	42,469,655 (GRCm39)	missense	probably benign	0.08
R1708:Gm2381	UTSW	7	42,469,649 (GRCm39)	missense	probably benign	0.05
R1909:Gm2381	UTSW	7	42,469,352 (GRCm39)	missense	probably damaging	1.00
R2848:Gm2381	UTSW	7	42,469,831 (GRCm39)	missense	probably damaging	0.98
R2849:Gm2381	UTSW	7	42,469,831 (GRCm39)	missense	probably damaging	0.98
R4437:Gm2381	UTSW	7	42,469,268 (GRCm39)	missense	probably damaging	1.00
R5445:Gm2381	UTSW	7	42,469,425 (GRCm39)	missense	probably damaging	0.96
R5702:Gm2381	UTSW	7	42,471,820 (GRCm39)	missense	probably benign	0.12
R6370:Gm2381	UTSW	7	42,470,010 (GRCm39)	missense	probably benign	0.00
R6371:Gm2381	UTSW	7	42,470,010 (GRCm39)	missense	probably benign	0.00
R6372:Gm2381	UTSW	7	42,470,010 (GRCm39)	missense	probably benign	0.00
R6688:Gm2381	UTSW	7	42,470,010 (GRCm39)	missense	probably benign	0.00
R7150:Gm2381	UTSW	7	42,469,888 (GRCm39)	missense	probably benign	0.04
R7336:Gm2381	UTSW	7	42,471,804 (GRCm39)	missense	possibly damaging	0.78
R8692:Gm2381	UTSW	7	42,472,071 (GRCm39)	missense	probably damaging	1.00
R9658:Gm2381	UTSW	7	42,469,729 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

Posted On

2013-10-16