Incidental Mutation 'R0849:Vmn2r-ps158'
ID |
77068 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r-ps158
|
Ensembl Gene |
ENSMUSG00000091528 |
Gene Name |
vomeronasal 2, receptor, pseudogene 158 |
Synonyms |
Vmn2r126, Gm9268 |
MMRRC Submission |
039028-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.079)
|
Stock # |
R0849 (G1)
|
Quality Score |
181 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
42668222-42697530 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 42674142 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Cysteine
at position 400
(Y400C)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000134441
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166914]
[ENSMUST00000173815]
|
AlphaFold |
E9Q0M3 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000166914
AA Change: Y407C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000129068 Gene: ENSMUSG00000091528 AA Change: Y407C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
473 |
1.1e-41 |
PFAM |
Pfam:NCD3G
|
516 |
569 |
1.7e-23 |
PFAM |
Pfam:7tm_3
|
602 |
837 |
9.6e-51 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000173815
AA Change: Y400C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000134441 Gene: ENSMUSG00000091528 AA Change: Y400C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
467 |
5.3e-40 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
4.6e-22 |
PFAM |
Pfam:7tm_3
|
594 |
831 |
1.1e-73 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.5%
- 10x: 96.5%
- 20x: 92.5%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 43 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Arhgap5 |
T |
C |
12: 52,566,406 (GRCm39) |
F1126L |
probably benign |
Het |
Arhgef11 |
G |
T |
3: 87,643,203 (GRCm39) |
A1472S |
probably benign |
Het |
Armc9 |
G |
A |
1: 86,184,992 (GRCm39) |
R681K |
probably benign |
Het |
Atxn2 |
T |
A |
5: 121,885,484 (GRCm39) |
|
probably null |
Het |
B3gnt6 |
C |
A |
7: 97,843,950 (GRCm39) |
L3F |
probably benign |
Het |
Cand2 |
A |
G |
6: 115,769,352 (GRCm39) |
T721A |
probably damaging |
Het |
Cntn2 |
A |
T |
1: 132,450,124 (GRCm39) |
M590K |
probably benign |
Het |
Cntn4 |
A |
T |
6: 106,644,418 (GRCm39) |
D622V |
probably damaging |
Het |
Des |
T |
G |
1: 75,337,272 (GRCm39) |
S71A |
probably benign |
Het |
Dnah5 |
C |
A |
15: 28,263,745 (GRCm39) |
R827S |
probably damaging |
Het |
Dstn |
G |
A |
2: 143,780,455 (GRCm39) |
G52S |
probably benign |
Het |
Eln |
T |
A |
5: 134,736,835 (GRCm39) |
R704* |
probably null |
Het |
Fezf2 |
T |
A |
14: 12,342,607 (GRCm38) |
K419N |
probably damaging |
Het |
Gm2381 |
G |
A |
7: 42,469,372 (GRCm39) |
Q251* |
probably null |
Het |
Grin3a |
G |
A |
4: 49,665,501 (GRCm39) |
R1045* |
probably null |
Het |
Herc2 |
T |
A |
7: 55,856,326 (GRCm39) |
H3921Q |
probably damaging |
Het |
Hs3st2 |
A |
G |
7: 121,100,255 (GRCm39) |
E367G |
possibly damaging |
Het |
Hydin |
G |
A |
8: 111,325,616 (GRCm39) |
R4675H |
probably damaging |
Het |
Inhca |
A |
C |
9: 103,140,256 (GRCm39) |
Y488D |
possibly damaging |
Het |
Irf2bp1 |
T |
C |
7: 18,738,659 (GRCm39) |
S100P |
possibly damaging |
Het |
Itga10 |
A |
G |
3: 96,559,846 (GRCm39) |
I500M |
possibly damaging |
Het |
Kcnt2 |
T |
C |
1: 140,435,500 (GRCm39) |
V496A |
probably damaging |
Het |
Mansc1 |
T |
C |
6: 134,587,670 (GRCm39) |
D169G |
probably benign |
Het |
Mdn1 |
T |
A |
4: 32,741,835 (GRCm39) |
S3869T |
probably damaging |
Het |
Mrgprb4 |
G |
A |
7: 47,848,868 (GRCm39) |
T20I |
probably benign |
Het |
Nek4 |
A |
G |
14: 30,679,253 (GRCm39) |
E198G |
probably damaging |
Het |
Or12e8 |
G |
T |
2: 87,188,609 (GRCm39) |
V274L |
probably benign |
Het |
Or2y10 |
G |
A |
11: 49,455,129 (GRCm39) |
C127Y |
probably damaging |
Het |
Or5w11 |
C |
A |
2: 87,459,626 (GRCm39) |
T273K |
possibly damaging |
Het |
Ppfia4 |
A |
T |
1: 134,247,110 (GRCm39) |
F537I |
probably benign |
Het |
Rarb |
A |
G |
14: 16,434,293 (GRCm38) |
V295A |
probably damaging |
Het |
Ryr1 |
A |
G |
7: 28,740,104 (GRCm39) |
S3941P |
probably damaging |
Het |
Scnn1b |
A |
G |
7: 121,511,698 (GRCm39) |
N370S |
probably damaging |
Het |
Stard9 |
C |
A |
2: 120,504,117 (GRCm39) |
S221R |
probably damaging |
Het |
Sv2c |
C |
T |
13: 96,126,319 (GRCm39) |
G311D |
probably damaging |
Het |
Tas2r109 |
T |
C |
6: 132,957,856 (GRCm39) |
I25V |
probably benign |
Het |
Tbcel |
A |
C |
9: 42,348,453 (GRCm39) |
I305S |
probably damaging |
Het |
Tmem35b |
A |
G |
4: 127,019,990 (GRCm39) |
|
probably null |
Het |
Tmem38b |
T |
C |
4: 53,840,765 (GRCm39) |
L60S |
probably damaging |
Het |
Tmtc4 |
A |
G |
14: 123,182,966 (GRCm39) |
I244T |
possibly damaging |
Het |
Usp9y |
C |
A |
Y: 1,394,002 (GRCm39) |
C576F |
probably damaging |
Het |
Vcan |
A |
T |
13: 89,853,072 (GRCm39) |
N629K |
possibly damaging |
Het |
Vmn2r22 |
T |
C |
6: 123,614,363 (GRCm39) |
Y409C |
probably damaging |
Het |
|
Other mutations in Vmn2r-ps158 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01676:Vmn2r-ps158
|
APN |
7 |
42,674,133 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL01753:Vmn2r-ps158
|
APN |
7 |
42,674,139 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02338:Vmn2r-ps158
|
APN |
7 |
42,697,160 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02541:Vmn2r-ps158
|
APN |
7 |
42,673,092 (GRCm39) |
splice site |
probably benign |
|
R0751:Vmn2r-ps158
|
UTSW |
7 |
42,696,833 (GRCm39) |
missense |
probably damaging |
0.99 |
R1460:Vmn2r-ps158
|
UTSW |
7 |
42,672,639 (GRCm39) |
missense |
probably benign |
0.25 |
R1617:Vmn2r-ps158
|
UTSW |
7 |
42,673,503 (GRCm39) |
missense |
probably benign |
0.18 |
R1962:Vmn2r-ps158
|
UTSW |
7 |
42,696,824 (GRCm39) |
missense |
probably benign |
0.00 |
R1999:Vmn2r-ps158
|
UTSW |
7 |
42,696,883 (GRCm39) |
missense |
probably damaging |
1.00 |
R2022:Vmn2r-ps158
|
UTSW |
7 |
42,673,454 (GRCm39) |
missense |
probably benign |
|
R2434:Vmn2r-ps158
|
UTSW |
7 |
42,696,881 (GRCm39) |
missense |
probably damaging |
0.99 |
R3760:Vmn2r-ps158
|
UTSW |
7 |
42,673,502 (GRCm39) |
missense |
probably benign |
0.00 |
R4562:Vmn2r-ps158
|
UTSW |
7 |
42,672,986 (GRCm39) |
nonsense |
probably null |
|
R4890:Vmn2r-ps158
|
UTSW |
7 |
42,697,024 (GRCm39) |
missense |
probably damaging |
1.00 |
R5221:Vmn2r-ps158
|
UTSW |
7 |
42,672,684 (GRCm39) |
missense |
probably benign |
0.31 |
R5597:Vmn2r-ps158
|
UTSW |
7 |
42,674,073 (GRCm39) |
missense |
probably benign |
0.01 |
R6589:Vmn2r-ps158
|
UTSW |
7 |
42,673,022 (GRCm39) |
missense |
possibly damaging |
0.91 |
R6831:Vmn2r-ps158
|
UTSW |
7 |
42,673,004 (GRCm39) |
missense |
probably damaging |
1.00 |
R6834:Vmn2r-ps158
|
UTSW |
7 |
42,673,004 (GRCm39) |
missense |
probably damaging |
1.00 |
R6910:Vmn2r-ps158
|
UTSW |
7 |
42,673,475 (GRCm39) |
missense |
probably benign |
0.01 |
R6944:Vmn2r-ps158
|
UTSW |
7 |
42,697,393 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7470:Vmn2r-ps158
|
UTSW |
7 |
42,697,310 (GRCm39) |
missense |
probably damaging |
1.00 |
R7553:Vmn2r-ps158
|
UTSW |
7 |
42,697,447 (GRCm39) |
missense |
probably damaging |
1.00 |
R7661:Vmn2r-ps158
|
UTSW |
7 |
42,672,582 (GRCm39) |
missense |
probably benign |
0.00 |
R7677:Vmn2r-ps158
|
UTSW |
7 |
42,674,163 (GRCm39) |
missense |
probably damaging |
1.00 |
R8087:Vmn2r-ps158
|
UTSW |
7 |
42,697,094 (GRCm39) |
missense |
probably benign |
0.04 |
R8210:Vmn2r-ps158
|
UTSW |
7 |
42,673,462 (GRCm39) |
missense |
probably benign |
0.16 |
R8379:Vmn2r-ps158
|
UTSW |
7 |
42,697,270 (GRCm39) |
missense |
probably damaging |
1.00 |
R8692:Vmn2r-ps158
|
UTSW |
7 |
42,697,108 (GRCm39) |
missense |
probably benign |
0.13 |
R8917:Vmn2r-ps158
|
UTSW |
7 |
42,697,433 (GRCm39) |
missense |
probably damaging |
1.00 |
R9255:Vmn2r-ps158
|
UTSW |
7 |
42,673,965 (GRCm39) |
missense |
possibly damaging |
0.75 |
R9375:Vmn2r-ps158
|
UTSW |
7 |
42,673,499 (GRCm39) |
missense |
possibly damaging |
0.87 |
R9452:Vmn2r-ps158
|
UTSW |
7 |
42,697,257 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9647:Vmn2r-ps158
|
UTSW |
7 |
42,697,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TGACATGGAAAGTCTGGGTCTTGAAC -3'
(R):5'- GCGTCTGCTCTGAGGAATATAAATGGG -3'
Sequencing Primer
(F):5'- AAGTCTGGGTCTTGAACTCTCAATG -3'
(R):5'- GTGAAACAGATATTCTCTTGCTTGC -3'
|
Posted On |
2013-10-16 |