Incidental Mutation 'R0840:Or56b1b'
ID 77112
Institutional Source Beutler Lab
Gene Symbol Or56b1b
Ensembl Gene ENSMUSG00000060105
Gene Name olfactory receptor family 56 subfamily B member 1B
Synonyms MOR40-15, MOR40-7P, Olfr504, GA_x6K02T2PBJ9-10895499-10894543
MMRRC Submission 039019-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R0840 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 108164044-108165000 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 108164823 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 60 (S60T)
Ref Sequence ENSEMBL: ENSMUSP00000075025 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075595]
AlphaFold Q7TRU7
Predicted Effect probably benign
Transcript: ENSMUST00000075595
AA Change: S60T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000075025
Gene: ENSMUSG00000060105
AA Change: S60T

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 3.9e-70 PFAM
Pfam:7TM_GPCR_Srsx 40 311 5.1e-10 PFAM
Pfam:7tm_1 47 296 3.1e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207199
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207240
Meta Mutation Damage Score 0.1102 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 94.1%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik C G 12: 71,205,657 (GRCm39) Q434E probably benign Het
A930011G23Rik T C 5: 99,382,547 (GRCm39) T234A probably benign Het
Acot5 G A 12: 84,122,614 (GRCm39) W399* probably null Het
Adra1a A G 14: 66,965,159 (GRCm39) E383G possibly damaging Het
Ahnak T A 19: 8,982,427 (GRCm39) I1237N probably damaging Het
Bsg A G 10: 79,545,519 (GRCm39) T28A probably damaging Het
Cacna1i A T 15: 80,243,150 (GRCm39) I436F possibly damaging Het
Cd109 T C 9: 78,571,612 (GRCm39) I417T probably benign Het
Cep295 A T 9: 15,245,611 (GRCm39) D948E probably benign Het
Cfap92 G T 6: 87,657,260 (GRCm39) noncoding transcript Het
Clcn3 C A 8: 61,382,188 (GRCm39) V467F probably benign Het
Cntnap3 T C 13: 64,935,724 (GRCm39) S380G possibly damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dll4 T A 2: 119,156,966 (GRCm39) N79K probably benign Het
Ep300 A T 15: 81,529,134 (GRCm39) N1558I unknown Het
Fblim1 A G 4: 141,308,320 (GRCm39) F330L possibly damaging Het
Fbxo46 T A 7: 18,871,073 (GRCm39) M564K possibly damaging Het
Fnip1 T A 11: 54,384,007 (GRCm39) probably benign Het
Foxl2 A T 9: 98,837,984 (GRCm39) K91* probably null Het
Gapvd1 C A 2: 34,619,125 (GRCm39) V83F probably benign Het
Guk1 G A 11: 59,075,921 (GRCm39) R146C probably damaging Het
Irf8 G A 8: 121,480,220 (GRCm39) G153S probably benign Het
Kcnu1 T A 8: 26,403,712 (GRCm39) M1K probably null Het
Krt32 G A 11: 99,972,068 (GRCm39) P427S probably benign Het
Lrp12 A G 15: 39,739,554 (GRCm39) S529P probably damaging Het
Mettl22 T C 16: 8,300,021 (GRCm39) V134A probably damaging Het
Morc2b G T 17: 33,355,086 (GRCm39) H895Q probably benign Het
Nrros T C 16: 31,962,241 (GRCm39) D556G probably damaging Het
Nrxn3 A G 12: 90,298,567 (GRCm39) S1367G possibly damaging Het
Or10al7 A G 17: 38,366,463 (GRCm39) F7S probably benign Het
Pcnx3 T A 19: 5,735,729 (GRCm39) probably null Het
Pgap2 A T 7: 101,886,655 (GRCm39) M226L probably damaging Het
Pik3c2g A G 6: 139,841,798 (GRCm39) I616M probably damaging Het
Pisd A G 5: 32,894,656 (GRCm39) I380T probably damaging Het
Pkhd1 T C 1: 20,420,745 (GRCm39) I2454V probably damaging Het
Plpp2 A G 10: 79,363,378 (GRCm39) I151T probably benign Het
Polr3a G A 14: 24,502,268 (GRCm39) T1295I possibly damaging Het
Pot1a T C 6: 25,748,283 (GRCm39) probably benign Het
Prpf39 T G 12: 65,094,980 (GRCm39) N219K probably benign Het
Rnf17 T A 14: 56,712,904 (GRCm39) N790K probably damaging Het
Slit3 C T 11: 35,514,263 (GRCm39) probably benign Het
Stx1a T A 5: 135,070,088 (GRCm39) probably benign Het
Tenm3 C A 8: 48,788,777 (GRCm39) V690F probably damaging Het
Tmcc3 A G 10: 94,414,633 (GRCm39) I143V probably benign Het
Tmem41b G A 7: 109,580,256 (GRCm39) S36F probably damaging Het
Trim5 A T 7: 103,914,978 (GRCm39) W364R probably damaging Het
Ttn T C 2: 76,617,155 (GRCm39) Y16403C probably damaging Het
Vps8 T C 16: 21,275,071 (GRCm39) S210P probably damaging Het
Zbtb3 T A 19: 8,780,821 (GRCm39) S145T possibly damaging Het
Zfp882 T A 8: 72,668,530 (GRCm39) C452* probably null Het
Other mutations in Or56b1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01358:Or56b1b APN 7 108,164,409 (GRCm39) missense probably benign 0.02
IGL01447:Or56b1b APN 7 108,164,216 (GRCm39) missense possibly damaging 0.75
IGL01845:Or56b1b APN 7 108,164,343 (GRCm39) missense possibly damaging 0.76
IGL02110:Or56b1b APN 7 108,164,286 (GRCm39) missense probably damaging 1.00
IGL03196:Or56b1b APN 7 108,164,061 (GRCm39) missense probably benign
R0282:Or56b1b UTSW 7 108,164,684 (GRCm39) missense probably damaging 1.00
R0359:Or56b1b UTSW 7 108,164,721 (GRCm39) missense probably benign 0.01
R0514:Or56b1b UTSW 7 108,164,879 (GRCm39) missense probably damaging 1.00
R0727:Or56b1b UTSW 7 108,164,315 (GRCm39) missense probably benign 0.00
R0744:Or56b1b UTSW 7 108,164,205 (GRCm39) missense possibly damaging 0.57
R0836:Or56b1b UTSW 7 108,164,205 (GRCm39) missense possibly damaging 0.57
R0883:Or56b1b UTSW 7 108,164,483 (GRCm39) missense probably benign 0.01
R1750:Or56b1b UTSW 7 108,164,564 (GRCm39) nonsense probably null
R1827:Or56b1b UTSW 7 108,164,282 (GRCm39) missense probably benign 0.35
R1933:Or56b1b UTSW 7 108,164,730 (GRCm39) missense possibly damaging 0.57
R3004:Or56b1b UTSW 7 108,164,151 (GRCm39) missense probably benign 0.42
R3766:Or56b1b UTSW 7 108,164,402 (GRCm39) missense probably benign 0.00
R5179:Or56b1b UTSW 7 108,164,433 (GRCm39) missense probably benign
R5408:Or56b1b UTSW 7 108,164,376 (GRCm39) missense probably damaging 0.99
R5493:Or56b1b UTSW 7 108,164,774 (GRCm39) missense probably benign 0.24
R5569:Or56b1b UTSW 7 108,164,772 (GRCm39) missense probably benign 0.01
R6520:Or56b1b UTSW 7 108,164,046 (GRCm39) makesense probably null
R6798:Or56b1b UTSW 7 108,164,967 (GRCm39) nonsense probably null
R6803:Or56b1b UTSW 7 108,164,620 (GRCm39) missense probably damaging 1.00
R7242:Or56b1b UTSW 7 108,164,919 (GRCm39) missense probably benign 0.03
R7559:Or56b1b UTSW 7 108,164,763 (GRCm39) missense probably damaging 0.99
R7644:Or56b1b UTSW 7 108,164,649 (GRCm39) missense possibly damaging 0.78
R8498:Or56b1b UTSW 7 108,164,833 (GRCm39) nonsense probably null
R8970:Or56b1b UTSW 7 108,164,997 (GRCm39) missense probably benign 0.00
R9014:Or56b1b UTSW 7 108,164,882 (GRCm39) missense possibly damaging 0.63
R9093:Or56b1b UTSW 7 108,164,454 (GRCm39) missense probably damaging 1.00
R9103:Or56b1b UTSW 7 108,164,780 (GRCm39) missense probably benign 0.02
R9548:Or56b1b UTSW 7 108,164,334 (GRCm39) missense possibly damaging 0.75
Predicted Primers PCR Primer
(F):5'- TGACACAGAAGCCATTTCTCAGCAC -3'
(R):5'- CCTCACAGGAAAATGTCTGCATCTCTC -3'

Sequencing Primer
(F):5'- TATCTGTCAAAAGCCATGCAGAG -3'
(R):5'- AATGTCTGCATCTCTCAAAGACTTC -3'
Posted On 2013-10-16