Incidental Mutation 'R0841:Zfp7'
ID 77183
Institutional Source Beutler Lab
Gene Symbol Zfp7
Ensembl Gene ENSMUSG00000033669
Gene Name zinc finger protein 7
Synonyms Zfp86-rs1, Zfp-7, Zfp65, Krox-2, KRAB20, Zfp80, mszf73-2, KRAB7
MMRRC Submission 039020-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0841 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 76763459-76776595 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 76775704 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 582 (C582Y)
Ref Sequence ENSEMBL: ENSMUSP00000155599 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023179] [ENSMUST00000229831] [ENSMUST00000229990] [ENSMUST00000230106] [ENSMUST00000230214]
AlphaFold Q3TFZ4
Predicted Effect probably damaging
Transcript: ENSMUST00000023179
AA Change: C582Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023179
Gene: ENSMUSG00000033669
AA Change: C582Y

DomainStartEndE-ValueType
KRAB 4 65 3.07e-33 SMART
ZnF_C2H2 192 214 6.88e-4 SMART
ZnF_C2H2 220 242 4.24e-4 SMART
ZnF_C2H2 248 270 2.09e-3 SMART
ZnF_C2H2 276 298 1.45e-2 SMART
ZnF_C2H2 304 326 1.13e-4 SMART
ZnF_C2H2 332 354 9.08e-4 SMART
ZnF_C2H2 360 383 2.24e-3 SMART
ZnF_C2H2 412 434 9.08e-4 SMART
ZnF_C2H2 440 462 1.67e-2 SMART
ZnF_C2H2 468 490 3.44e-4 SMART
ZnF_C2H2 496 518 8.47e-4 SMART
ZnF_C2H2 524 546 4.54e-4 SMART
ZnF_C2H2 552 574 7.9e-4 SMART
ZnF_C2H2 580 602 1.72e-4 SMART
ZnF_C2H2 633 655 1.98e-4 SMART
ZnF_C2H2 661 683 4.79e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229729
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229782
Predicted Effect probably benign
Transcript: ENSMUST00000229831
Predicted Effect probably benign
Transcript: ENSMUST00000229990
Predicted Effect probably damaging
Transcript: ENSMUST00000230106
AA Change: C582Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230954
Predicted Effect probably benign
Transcript: ENSMUST00000230214
Meta Mutation Damage Score 0.3052 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.1%
  • 10x: 97.4%
  • 20x: 94.1%
Validation Efficiency 94% (45/48)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310002L09Rik T A 4: 73,860,986 (GRCm39) M205L probably benign Het
Aass A T 6: 23,075,810 (GRCm39) C776S probably benign Het
Abi3bp T C 16: 56,488,639 (GRCm39) S1257P possibly damaging Het
Arhgap9 T A 10: 127,165,508 (GRCm39) M639K probably damaging Het
Ctsj C T 13: 61,150,357 (GRCm39) S214N probably damaging Het
Dnali1 T C 4: 124,959,340 (GRCm39) S18G possibly damaging Het
Eif4g3 C T 4: 137,893,129 (GRCm39) T959M probably damaging Het
Eml3 G A 19: 8,915,049 (GRCm39) M635I probably benign Het
Eml6 A G 11: 29,727,430 (GRCm39) F1231L probably benign Het
Fat4 A C 3: 39,050,147 (GRCm39) K4003T probably damaging Het
Fcho1 C T 8: 72,165,204 (GRCm39) A418T probably benign Het
Fgfr2 G A 7: 129,863,635 (GRCm39) P4S probably benign Het
Fgfr2 T C 7: 130,373,737 (GRCm39) probably benign Het
Glp1r T C 17: 31,138,406 (GRCm39) V160A probably benign Het
Gm9726 C T 12: 93,895,054 (GRCm39) noncoding transcript Het
Gm9956 C A 10: 56,621,424 (GRCm39) L29M unknown Het
Gm9956 T A 10: 56,621,425 (GRCm39) L29Q unknown Het
Hddc3 T A 7: 79,995,401 (GRCm39) S139T probably benign Het
Hmcn1 A T 1: 150,555,358 (GRCm39) probably null Het
Inpp5k T C 11: 75,524,285 (GRCm39) probably benign Het
Kcnq1 A G 7: 142,661,189 (GRCm39) K32E probably benign Het
Krtdap A T 7: 30,488,975 (GRCm39) probably benign Het
Ldb2 A G 5: 44,690,016 (GRCm39) L201P probably damaging Het
Mdn1 T C 4: 32,752,032 (GRCm39) V4590A probably benign Het
Nip7 C A 8: 107,784,007 (GRCm39) H82Q probably benign Het
Odad2 G T 18: 7,268,436 (GRCm39) P361Q probably damaging Het
Or52l1 A T 7: 104,830,061 (GRCm39) V168E probably damaging Het
Otud6b T A 4: 14,812,532 (GRCm39) T272S probably benign Het
Plxna1 A G 6: 89,309,186 (GRCm39) V1131A probably damaging Het
Prl7a1 T A 13: 27,826,393 (GRCm39) probably benign Het
Sipa1 C A 19: 5,704,835 (GRCm39) A587S probably benign Het
Slc17a6 A T 7: 51,275,063 (GRCm39) I41F probably benign Het
Slc43a2 T A 11: 75,457,815 (GRCm39) Y363* probably null Het
Smg1 A T 7: 117,742,524 (GRCm39) L3230Q possibly damaging Het
Snapc1 C T 12: 74,021,780 (GRCm39) probably benign Het
Syne2 T C 12: 76,121,209 (GRCm39) probably benign Het
Tap2 C A 17: 34,434,914 (GRCm39) D652E possibly damaging Het
Trp53rkb T C 2: 166,637,430 (GRCm39) C129R probably benign Het
Ugt2a2 T C 5: 87,622,648 (GRCm39) T317A probably benign Het
Ugt3a1 G A 15: 9,306,214 (GRCm39) S121N probably benign Het
Unc80 T C 1: 66,511,247 (GRCm39) V85A probably damaging Het
Vmn2r71 A G 7: 85,267,749 (GRCm39) T68A possibly damaging Het
Other mutations in Zfp7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00576:Zfp7 APN 15 76,775,101 (GRCm39) intron probably benign
IGL01509:Zfp7 APN 15 76,765,333 (GRCm39) missense probably damaging 1.00
IGL01694:Zfp7 APN 15 76,774,995 (GRCm39) nonsense probably null
IGL01731:Zfp7 APN 15 76,772,505 (GRCm39) nonsense probably null
IGL02025:Zfp7 APN 15 76,772,464 (GRCm39) missense probably damaging 1.00
R1345:Zfp7 UTSW 15 76,774,908 (GRCm39) missense probably damaging 1.00
R1625:Zfp7 UTSW 15 76,765,374 (GRCm39) missense probably damaging 1.00
R1872:Zfp7 UTSW 15 76,775,977 (GRCm39) missense probably benign 0.00
R2330:Zfp7 UTSW 15 76,775,509 (GRCm39) missense probably damaging 1.00
R4170:Zfp7 UTSW 15 76,775,818 (GRCm39) missense probably benign 0.00
R4795:Zfp7 UTSW 15 76,775,546 (GRCm39) nonsense probably null
R4796:Zfp7 UTSW 15 76,775,546 (GRCm39) nonsense probably null
R5038:Zfp7 UTSW 15 76,776,010 (GRCm39) missense probably benign 0.01
R5277:Zfp7 UTSW 15 76,765,403 (GRCm39) missense probably damaging 1.00
R5285:Zfp7 UTSW 15 76,775,422 (GRCm39) missense probably damaging 1.00
R5287:Zfp7 UTSW 15 76,775,422 (GRCm39) missense probably damaging 1.00
R5445:Zfp7 UTSW 15 76,775,054 (GRCm39) nonsense probably null
R5655:Zfp7 UTSW 15 76,775,629 (GRCm39) missense probably damaging 1.00
R6320:Zfp7 UTSW 15 76,774,810 (GRCm39) missense possibly damaging 0.79
R7063:Zfp7 UTSW 15 76,775,919 (GRCm39) missense possibly damaging 0.82
R8110:Zfp7 UTSW 15 76,775,131 (GRCm39) missense possibly damaging 0.94
R9058:Zfp7 UTSW 15 76,764,981 (GRCm39) start codon destroyed probably null 0.77
R9205:Zfp7 UTSW 15 76,774,800 (GRCm39) intron probably benign
R9206:Zfp7 UTSW 15 76,774,800 (GRCm39) intron probably benign
R9352:Zfp7 UTSW 15 76,775,674 (GRCm39) missense probably damaging 1.00
R9364:Zfp7 UTSW 15 76,774,800 (GRCm39) intron probably benign
R9368:Zfp7 UTSW 15 76,774,800 (GRCm39) intron probably benign
R9369:Zfp7 UTSW 15 76,774,800 (GRCm39) intron probably benign
R9372:Zfp7 UTSW 15 76,774,800 (GRCm39) intron probably benign
R9373:Zfp7 UTSW 15 76,774,800 (GRCm39) intron probably benign
R9373:Zfp7 UTSW 15 76,774,798 (GRCm39) intron probably benign
R9513:Zfp7 UTSW 15 76,775,484 (GRCm39) missense probably damaging 1.00
R9515:Zfp7 UTSW 15 76,775,484 (GRCm39) missense probably damaging 1.00
R9516:Zfp7 UTSW 15 76,775,484 (GRCm39) missense probably damaging 1.00
R9623:Zfp7 UTSW 15 76,774,531 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- AGCCCAAGCCTTATTGCCTGTC -3'
(R):5'- TCGCAGTCGTCACACTGGTACAAC -3'

Sequencing Primer
(F):5'- aatgtgacgaatgtggcaag -3'
(R):5'- GTCACACTGGTACAACTTTTTTACAG -3'
Posted On 2013-10-16